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Metabolic effects of milk protein intake strongly depend on pre-existing metabolic and exercise status

Melnik, Bodo C. ; Schmitz, Gerd ; John, Swen Malte ; Carrera Bastos, Pedro LU ; Lindeberg, Staffan LU and Cordain, Loren (2013) In Nutrition & Metabolism 10.
Abstract
Milk protein intake has recently been suggested to improve metabolic health. This Perspective provides evidence that metabolic effects of milk protein intake have to be regarded in the context of the individual's pre-existing metabolic and exercise status. Milk proteins provide abundant branched-chain amino acids (BCAAs) and glutamine. Plasma BCAAs and glutamine are increased in obesity and insulin resistance, but decrease after gastric bypass surgery resulting in weight loss and improved insulin sensitivity. Milk protein consumption results in postprandial hyperinsulinemia in obese subjects, increases body weight of overweight adolescents and may thus deteriorate pre-existing metabolic disturbances of obese, insulin resistant individuals.
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adipogenesis, Body weight, Branched-chain amino acids, Glutaminolysis, Insulin resistance, Milk proteins, microRNA, mTORC1, Obesity, Prostate, cancer
in
Nutrition & Metabolism
volume
10
article number
60
publisher
BioMed Central (BMC)
external identifiers
  • wos:000325211500001
  • scopus:84884743285
  • pmid:24225036
ISSN
1743-7075
DOI
10.1186/1743-7075-10-60
language
English
LU publication?
yes
id
ed0a1b14-9dfc-493c-8725-a374142c3cab (old id 4171803)
date added to LUP
2016-04-01 14:41:30
date last changed
2022-04-19 11:07:29
@article{ed0a1b14-9dfc-493c-8725-a374142c3cab,
  abstract     = {{Milk protein intake has recently been suggested to improve metabolic health. This Perspective provides evidence that metabolic effects of milk protein intake have to be regarded in the context of the individual's pre-existing metabolic and exercise status. Milk proteins provide abundant branched-chain amino acids (BCAAs) and glutamine. Plasma BCAAs and glutamine are increased in obesity and insulin resistance, but decrease after gastric bypass surgery resulting in weight loss and improved insulin sensitivity. Milk protein consumption results in postprandial hyperinsulinemia in obese subjects, increases body weight of overweight adolescents and may thus deteriorate pre-existing metabolic disturbances of obese, insulin resistant individuals.}},
  author       = {{Melnik, Bodo C. and Schmitz, Gerd and John, Swen Malte and Carrera Bastos, Pedro and Lindeberg, Staffan and Cordain, Loren}},
  issn         = {{1743-7075}},
  keywords     = {{Adipogenesis; Body weight; Branched-chain amino acids; Glutaminolysis; Insulin resistance; Milk proteins; microRNA; mTORC1; Obesity; Prostate; cancer}},
  language     = {{eng}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Nutrition & Metabolism}},
  title        = {{Metabolic effects of milk protein intake strongly depend on pre-existing metabolic and exercise status}},
  url          = {{https://lup.lub.lu.se/search/files/4113216/4431955.pdf}},
  doi          = {{10.1186/1743-7075-10-60}},
  volume       = {{10}},
  year         = {{2013}},
}