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Nerve compression induces activating transcription factor 3 in neurons and Schwann cells in diabetic rats.

Dahlin, Lars LU orcid ; Stenberg, Lena LU orcid ; Luthman, Holger LU and Thomsen, Niels LU (2008) In NeuroReport 19(9). p.987-990
Abstract
Expression of transcription factor ATF3 in sensory neurons in dorsal root ganglion and in Schwann cells in sciatic nerve of diabetic (BB and Goto-Kakizaki rats; experimental models of types 1 and 2 diabetes, respectively) and healthy rats were examined by immunocytochemistry after nerve compression (silicone tube) for 3, 6 or 14 days. ATF3-stained sensory neurons in dorsal root ganglia and Schwann cells at compression site were more frequent in diabetic BB rats. Decompression of nerves in Goto-Kakizaki rats did not reduce number of ATF3-stained cells. Diabetes (BB; i.e. type 1) confers on the peripheral nerve an increased susceptibility to nerve compression indicated by an increased expression of stained ATF3 neurons and Schwann cells.
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
NeuroReport
volume
19
issue
9
pages
987 - 990
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000256741800017
  • pmid:18521006
  • scopus:52249089449
ISSN
1473-558X
DOI
10.1097/WNR.0b013e328302f4ec
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Genetics Unit (013241550), Reconstructive Surgery (013240300), Hand Surgery Research Group (013241910)
id
ed5ead33-fcf4-4736-8b40-971319b1c677 (old id 1169296)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18521006?dopt=Abstract
date added to LUP
2016-04-04 07:01:00
date last changed
2022-04-23 03:57:49
@article{ed5ead33-fcf4-4736-8b40-971319b1c677,
  abstract     = {{Expression of transcription factor ATF3 in sensory neurons in dorsal root ganglion and in Schwann cells in sciatic nerve of diabetic (BB and Goto-Kakizaki rats; experimental models of types 1 and 2 diabetes, respectively) and healthy rats were examined by immunocytochemistry after nerve compression (silicone tube) for 3, 6 or 14 days. ATF3-stained sensory neurons in dorsal root ganglia and Schwann cells at compression site were more frequent in diabetic BB rats. Decompression of nerves in Goto-Kakizaki rats did not reduce number of ATF3-stained cells. Diabetes (BB; i.e. type 1) confers on the peripheral nerve an increased susceptibility to nerve compression indicated by an increased expression of stained ATF3 neurons and Schwann cells.}},
  author       = {{Dahlin, Lars and Stenberg, Lena and Luthman, Holger and Thomsen, Niels}},
  issn         = {{1473-558X}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{987--990}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{NeuroReport}},
  title        = {{Nerve compression induces activating transcription factor 3 in neurons and Schwann cells in diabetic rats.}},
  url          = {{http://dx.doi.org/10.1097/WNR.0b013e328302f4ec}},
  doi          = {{10.1097/WNR.0b013e328302f4ec}},
  volume       = {{19}},
  year         = {{2008}},
}