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The Burden of Multiple Basal Cell Carcinomas : A Population-wide Study

Kappelin, Johan LU ; Ahnlide, Ingela LU ; Ingvar, Åsa LU orcid and Nielsen, Kari LU orcid (2024) In Acta Dermato-Venereologica 104.
Abstract

Basal cell carcinoma (BCC) is a common skin cancer type and affected individuals are known to be at risk of developing multiple consecutive tumours. Research into BCC multiplicity has, thus far, been challenging, due to a lack of national registration. This registry-based cohort study aimed to analyse the occurrence of multiple BCCs in Sweden, and risk factors for subsequent primary BCCs. Data regarding all histopathologically verified, primary BCC tumours in Sweden from 2004 to 2017 was extracted from the Swedish BCC Registry. Risk of developing a subsequent BCC in relation to person-related factors was estimated with Cox regression analysis. Cumulative risk of BCC development after 1 or 3 earlier BCCs was estimated. In total, 39.9% of... (More)

Basal cell carcinoma (BCC) is a common skin cancer type and affected individuals are known to be at risk of developing multiple consecutive tumours. Research into BCC multiplicity has, thus far, been challenging, due to a lack of national registration. This registry-based cohort study aimed to analyse the occurrence of multiple BCCs in Sweden, and risk factors for subsequent primary BCCs. Data regarding all histopathologically verified, primary BCC tumours in Sweden from 2004 to 2017 was extracted from the Swedish BCC Registry. Risk of developing a subsequent BCC in relation to person-related factors was estimated with Cox regression analysis. Cumulative risk of BCC development after 1 or 3 earlier BCCs was estimated. In total, 39.9% of individuals with a registered BCC had at least 2 registered tumours. The risk of developing a subsequent BCC increased significantly in males, older age, and with residence in southern Sweden. The cumulative 5-year risk of developing an additional BCC after first diagnosis was approximately 30% in males and 27% in females and increased after multiple previous BCCs. This study showed the cumulative risk of a subsequent BCC to increase with a history of multiple BCCs, indicating the need for clinical surveillance in these individuals.

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Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Humans, Carcinoma, Basal Cell/epidemiology, Skin Neoplasms/epidemiology, Male, Female, Sweden/epidemiology, Registries, Middle Aged, Aged, Risk Factors, Adult, Aged, 80 and over, Neoplasms, Multiple Primary/epidemiology, Risk Assessment, Time Factors, Sex Factors, Age Factors, Young Adult, Hamartoma Syndrome, Multiple
in
Acta Dermato-Venereologica
volume
104
article number
adv40112
publisher
Medical Journals Limited
external identifiers
  • scopus:85194518968
  • pmid:38803206
ISSN
1651-2057
DOI
10.2340/actadv.v104.40112
language
English
LU publication?
yes
id
ee6b3a2e-bb1e-4eca-8ff4-24f1f10f98a5
date added to LUP
2024-08-16 10:24:29
date last changed
2024-08-31 06:21:39
@article{ee6b3a2e-bb1e-4eca-8ff4-24f1f10f98a5,
  abstract     = {{<p>Basal cell carcinoma (BCC) is a common skin cancer type and affected individuals are known to be at risk of developing multiple consecutive tumours. Research into BCC multiplicity has, thus far, been challenging, due to a lack of national registration. This registry-based cohort study aimed to analyse the occurrence of multiple BCCs in Sweden, and risk factors for subsequent primary BCCs. Data regarding all histopathologically verified, primary BCC tumours in Sweden from 2004 to 2017 was extracted from the Swedish BCC Registry. Risk of developing a subsequent BCC in relation to person-related factors was estimated with Cox regression analysis. Cumulative risk of BCC development after 1 or 3 earlier BCCs was estimated. In total, 39.9% of individuals with a registered BCC had at least 2 registered tumours. The risk of developing a subsequent BCC increased significantly in males, older age, and with residence in southern Sweden. The cumulative 5-year risk of developing an additional BCC after first diagnosis was approximately 30% in males and 27% in females and increased after multiple previous BCCs. This study showed the cumulative risk of a subsequent BCC to increase with a history of multiple BCCs, indicating the need for clinical surveillance in these individuals.</p>}},
  author       = {{Kappelin, Johan and Ahnlide, Ingela and Ingvar, Åsa and Nielsen, Kari}},
  issn         = {{1651-2057}},
  keywords     = {{Humans; Carcinoma, Basal Cell/epidemiology; Skin Neoplasms/epidemiology; Male; Female; Sweden/epidemiology; Registries; Middle Aged; Aged; Risk Factors; Adult; Aged, 80 and over; Neoplasms, Multiple Primary/epidemiology; Risk Assessment; Time Factors; Sex Factors; Age Factors; Young Adult; Hamartoma Syndrome, Multiple}},
  language     = {{eng}},
  month        = {{05}},
  publisher    = {{Medical Journals Limited}},
  series       = {{Acta Dermato-Venereologica}},
  title        = {{The Burden of Multiple Basal Cell Carcinomas : A Population-wide Study}},
  url          = {{http://dx.doi.org/10.2340/actadv.v104.40112}},
  doi          = {{10.2340/actadv.v104.40112}},
  volume       = {{104}},
  year         = {{2024}},
}