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Estrogen receptor alpha single nucleotide polymorphism as predictor of diabetes type 2 risk in hypogonadal men.

Linnér, Carl LU ; Svartberg, Johan ; Giwercman, Aleksander LU and Giwercman, Yvonne Lundberg LU (2013) In The Aging Male 16(2). p.52-57
Abstract
Abstract Estradiol (E2) is, apart from its role as a reproductive hormone, also important for cardiac function and bone maturation in both genders. It has also been shown to play a role in insulin production, energy expenditure and in inducing lipolysis. The aim of the study was to investigate if low circulating testosterone or E2 levels in combination with variants in the estrogen receptor alpha (ESR1) and estrogen receptor beta (ESR2) genes were of importance for the risk of type-2 diabetes. The single nucleotide polymorphisms rs2207396 and rs1256049, in ESR1 and ESR2, respectively, were analysed by allele specific PCR in 172 elderly men from the population-based Tromsø study. The results were adjusted for age. In individuals with low... (More)
Abstract Estradiol (E2) is, apart from its role as a reproductive hormone, also important for cardiac function and bone maturation in both genders. It has also been shown to play a role in insulin production, energy expenditure and in inducing lipolysis. The aim of the study was to investigate if low circulating testosterone or E2 levels in combination with variants in the estrogen receptor alpha (ESR1) and estrogen receptor beta (ESR2) genes were of importance for the risk of type-2 diabetes. The single nucleotide polymorphisms rs2207396 and rs1256049, in ESR1 and ESR2, respectively, were analysed by allele specific PCR in 172 elderly men from the population-based Tromsø study. The results were adjusted for age. In individuals with low total (≤11 nmol/L) or free testosterone (≤0.18 nmol/L) being carriers of the variant A-allele in ESR1 was associated with 7.3 and 15.9 times, respectively, increased odds ratio of being diagnosed with diabetes mellitus type 2 (p = 0.025 and p = 0.018, respectively). Lower concentrations of E2 did not seem to increase the risk of being diagnosed with diabetes. In conclusion, in hypogonadal men, the rs2207396 variant in ESR1 predicts the risk of type 2 diabetes. (Less)
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Aging Male
volume
16
issue
2
pages
52 - 57
publisher
Informa Healthcare
external identifiers
  • wos:000319129900005
  • pmid:23506158
  • scopus:84877935394
  • pmid:23506158
ISSN
1473-0790
DOI
10.3109/13685538.2013.772134
language
English
LU publication?
yes
id
eef9f42a-5f3f-479e-8575-7ede619f27d4 (old id 3628034)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23506158?dopt=Abstract
date added to LUP
2016-04-01 10:04:51
date last changed
2024-02-15 13:45:50
@article{eef9f42a-5f3f-479e-8575-7ede619f27d4,
  abstract     = {{Abstract Estradiol (E2) is, apart from its role as a reproductive hormone, also important for cardiac function and bone maturation in both genders. It has also been shown to play a role in insulin production, energy expenditure and in inducing lipolysis. The aim of the study was to investigate if low circulating testosterone or E2 levels in combination with variants in the estrogen receptor alpha (ESR1) and estrogen receptor beta (ESR2) genes were of importance for the risk of type-2 diabetes. The single nucleotide polymorphisms rs2207396 and rs1256049, in ESR1 and ESR2, respectively, were analysed by allele specific PCR in 172 elderly men from the population-based Tromsø study. The results were adjusted for age. In individuals with low total (≤11 nmol/L) or free testosterone (≤0.18 nmol/L) being carriers of the variant A-allele in ESR1 was associated with 7.3 and 15.9 times, respectively, increased odds ratio of being diagnosed with diabetes mellitus type 2 (p = 0.025 and p = 0.018, respectively). Lower concentrations of E2 did not seem to increase the risk of being diagnosed with diabetes. In conclusion, in hypogonadal men, the rs2207396 variant in ESR1 predicts the risk of type 2 diabetes.}},
  author       = {{Linnér, Carl and Svartberg, Johan and Giwercman, Aleksander and Giwercman, Yvonne Lundberg}},
  issn         = {{1473-0790}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{52--57}},
  publisher    = {{Informa Healthcare}},
  series       = {{The Aging Male}},
  title        = {{Estrogen receptor alpha single nucleotide polymorphism as predictor of diabetes type 2 risk in hypogonadal men.}},
  url          = {{https://lup.lub.lu.se/search/files/1543792/3910622.pdf}},
  doi          = {{10.3109/13685538.2013.772134}},
  volume       = {{16}},
  year         = {{2013}},
}