Fibrocytes and the tissue niche in lung repair
Andersson Sjöland, Annika LU ; Nihlberg, Kristian LU ; Eriksson, Leif LU ; Bjermer, Leif LU and Westergren-Thorsson, Gunilla LU
(2011)
In Respiratory Research
12.
- Abstract
- Human fibrocytes are bone marrow-derived mesenchymal progenitor cells that express a variety of markers related to leukocytes, hematopoietic stem cells and a diverse set of fibroblast phenotypes. Fibrocytes can be recruited from the circulation to the tissue where they further can differentiate and proliferate into various mesenchymal cell types depending on the tissue niche. This local tissue niche is important because it modulates the fibrocytes and coordinates their role in tissue behaviour and repair. However, plasticity of a niche may be co-opted in chronic airway diseases such as asthma, idiopathic pulmonary fibrosis and obliterative bronchiolitis. This review will therefore focus on a possible role of fibrocytes in pathological... (More)
- Human fibrocytes are bone marrow-derived mesenchymal progenitor cells that express a variety of markers related to leukocytes, hematopoietic stem cells and a diverse set of fibroblast phenotypes. Fibrocytes can be recruited from the circulation to the tissue where they further can differentiate and proliferate into various mesenchymal cell types depending on the tissue niche. This local tissue niche is important because it modulates the fibrocytes and coordinates their role in tissue behaviour and repair. However, plasticity of a niche may be co-opted in chronic airway diseases such as asthma, idiopathic pulmonary fibrosis and obliterative bronchiolitis. This review will therefore focus on a possible role of fibrocytes in pathological tissue repair processes in those diseases. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2092850
- author
- Andersson Sjöland, Annika
LU
; Nihlberg, Kristian
LU
; Eriksson, Leif
LU
; Bjermer, Leif
LU
and Westergren-Thorsson, Gunilla
LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Respiratory Research
- volume
- 12
- publisher
- BioMed Central (BMC)
- external identifiers
-
- wos:000292596900001
- scopus:79958055758
- pmid:21658209
- ISSN
- 1465-9921
- DOI
- 10.1186/1465-9921-12-76
- language
- English
- LU publication?
- yes
- id
- ef0d2597-ae67-400f-84d5-bb37f0da8589 (old id 2092850)
- date added to LUP
- 2016-04-01 09:58:16
- date last changed
- 2025-04-04 15:20:24
@article{ef0d2597-ae67-400f-84d5-bb37f0da8589,
abstract = {{Human fibrocytes are bone marrow-derived mesenchymal progenitor cells that express a variety of markers related to leukocytes, hematopoietic stem cells and a diverse set of fibroblast phenotypes. Fibrocytes can be recruited from the circulation to the tissue where they further can differentiate and proliferate into various mesenchymal cell types depending on the tissue niche. This local tissue niche is important because it modulates the fibrocytes and coordinates their role in tissue behaviour and repair. However, plasticity of a niche may be co-opted in chronic airway diseases such as asthma, idiopathic pulmonary fibrosis and obliterative bronchiolitis. This review will therefore focus on a possible role of fibrocytes in pathological tissue repair processes in those diseases.}},
author = {{Andersson Sjöland, Annika and Nihlberg, Kristian and Eriksson, Leif and Bjermer, Leif and Westergren-Thorsson, Gunilla}},
issn = {{1465-9921}},
language = {{eng}},
publisher = {{BioMed Central (BMC)}},
series = {{Respiratory Research}},
title = {{Fibrocytes and the tissue niche in lung repair}},
url = {{https://lup.lub.lu.se/search/files/1435113/2214226.pdf}},
doi = {{10.1186/1465-9921-12-76}},
volume = {{12}},
year = {{2011}},
}