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Temperature and pH Controlled Self-Assembly of a Protein-Polymer Biohybrid

Jiang, Lingdong LU ; Bonde, Johan Svensson LU and Ye, Lei LU (2018) In Macromolecular Chemistry and Physics
Abstract

A novel pH and temperature dual-responsive bioconjugate is prepared by grafting thermoresponsive polymer chains from a pH-responsive protein amelogenin via atom transfer radical polymerization. To the best of our knowledge, this is the first time that amelogenin is exploited to prepare a hybrid biomaterial with new stimuli-responsive property. In both basic and acidic solutions the protein-polymer bioconjugate is able to self-assemble into uniform and stable nanoparticles when heated to above the lower critical solution temperature of the polymer. The amelogenin-based stimuli-responsive bioconjugate may be of great use in the fields of bioseparation and drug/gene delivery, and the synthetic approach reported here should provide a... (More)

A novel pH and temperature dual-responsive bioconjugate is prepared by grafting thermoresponsive polymer chains from a pH-responsive protein amelogenin via atom transfer radical polymerization. To the best of our knowledge, this is the first time that amelogenin is exploited to prepare a hybrid biomaterial with new stimuli-responsive property. In both basic and acidic solutions the protein-polymer bioconjugate is able to self-assemble into uniform and stable nanoparticles when heated to above the lower critical solution temperature of the polymer. The amelogenin-based stimuli-responsive bioconjugate may be of great use in the fields of bioseparation and drug/gene delivery, and the synthetic approach reported here should provide a convenient means to preparing amelogenin-based functional biohybrid materials.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Amelogenin, Atom transfer radical polymerization, Bioconjugate, Dual-responsive, Self-assembly
in
Macromolecular Chemistry and Physics
publisher
John Wiley & Sons
external identifiers
  • scopus:85040775023
ISSN
1022-1352
DOI
10.1002/macp.201700597
language
English
LU publication?
yes
id
ef2c9d23-3da9-42bf-985d-8d78cf166dd2
date added to LUP
2018-01-30 13:57:53
date last changed
2018-05-29 11:51:48
@article{ef2c9d23-3da9-42bf-985d-8d78cf166dd2,
  abstract     = {<p>A novel pH and temperature dual-responsive bioconjugate is prepared by grafting thermoresponsive polymer chains from a pH-responsive protein amelogenin via atom transfer radical polymerization. To the best of our knowledge, this is the first time that amelogenin is exploited to prepare a hybrid biomaterial with new stimuli-responsive property. In both basic and acidic solutions the protein-polymer bioconjugate is able to self-assemble into uniform and stable nanoparticles when heated to above the lower critical solution temperature of the polymer. The amelogenin-based stimuli-responsive bioconjugate may be of great use in the fields of bioseparation and drug/gene delivery, and the synthetic approach reported here should provide a convenient means to preparing amelogenin-based functional biohybrid materials.</p>},
  author       = {Jiang, Lingdong and Bonde, Johan Svensson and Ye, Lei},
  issn         = {1022-1352},
  keyword      = {Amelogenin,Atom transfer radical polymerization,Bioconjugate,Dual-responsive,Self-assembly},
  language     = {eng},
  month        = {01},
  publisher    = {John Wiley & Sons},
  series       = {Macromolecular Chemistry and Physics},
  title        = {Temperature and pH Controlled Self-Assembly of a Protein-Polymer Biohybrid},
  url          = {http://dx.doi.org/10.1002/macp.201700597},
  year         = {2018},
}