Temperature and pH Controlled Self-Assembly of a Protein-Polymer Biohybrid
(2018) In Macromolecular Chemistry and Physics 219(7).- Abstract
A novel pH and temperature dual-responsive bioconjugate is prepared by grafting thermoresponsive polymer chains from a pH-responsive protein amelogenin via atom transfer radical polymerization. To the best of our knowledge, this is the first time that amelogenin is exploited to prepare a hybrid biomaterial with new stimuli-responsive property. In both basic and acidic solutions the protein-polymer bioconjugate is able to self-assemble into uniform and stable nanoparticles when heated to above the lower critical solution temperature of the polymer. The amelogenin-based stimuli-responsive bioconjugate may be of great use in the fields of bioseparation and drug/gene delivery, and the synthetic approach reported here should provide a... (More)
A novel pH and temperature dual-responsive bioconjugate is prepared by grafting thermoresponsive polymer chains from a pH-responsive protein amelogenin via atom transfer radical polymerization. To the best of our knowledge, this is the first time that amelogenin is exploited to prepare a hybrid biomaterial with new stimuli-responsive property. In both basic and acidic solutions the protein-polymer bioconjugate is able to self-assemble into uniform and stable nanoparticles when heated to above the lower critical solution temperature of the polymer. The amelogenin-based stimuli-responsive bioconjugate may be of great use in the fields of bioseparation and drug/gene delivery, and the synthetic approach reported here should provide a convenient means to preparing amelogenin-based functional biohybrid materials.
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- author
- Jiang, Lingdong LU ; Bonde, Johan Svensson LU and Ye, Lei LU
- organization
- publishing date
- 2018-01-30
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Amelogenin, Atom transfer radical polymerization, Bioconjugate, Dual-responsive, Self-assembly
- in
- Macromolecular Chemistry and Physics
- volume
- 219
- issue
- 7
- article number
- 1700597
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:85040775023
- ISSN
- 1022-1352
- DOI
- 10.1002/macp.201700597
- language
- English
- LU publication?
- yes
- id
- ef2c9d23-3da9-42bf-985d-8d78cf166dd2
- date added to LUP
- 2018-01-30 13:57:53
- date last changed
- 2023-10-19 23:18:00
@article{ef2c9d23-3da9-42bf-985d-8d78cf166dd2, abstract = {{<p>A novel pH and temperature dual-responsive bioconjugate is prepared by grafting thermoresponsive polymer chains from a pH-responsive protein amelogenin via atom transfer radical polymerization. To the best of our knowledge, this is the first time that amelogenin is exploited to prepare a hybrid biomaterial with new stimuli-responsive property. In both basic and acidic solutions the protein-polymer bioconjugate is able to self-assemble into uniform and stable nanoparticles when heated to above the lower critical solution temperature of the polymer. The amelogenin-based stimuli-responsive bioconjugate may be of great use in the fields of bioseparation and drug/gene delivery, and the synthetic approach reported here should provide a convenient means to preparing amelogenin-based functional biohybrid materials.</p>}}, author = {{Jiang, Lingdong and Bonde, Johan Svensson and Ye, Lei}}, issn = {{1022-1352}}, keywords = {{Amelogenin; Atom transfer radical polymerization; Bioconjugate; Dual-responsive; Self-assembly}}, language = {{eng}}, month = {{01}}, number = {{7}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Macromolecular Chemistry and Physics}}, title = {{Temperature and pH Controlled Self-Assembly of a Protein-Polymer Biohybrid}}, url = {{http://dx.doi.org/10.1002/macp.201700597}}, doi = {{10.1002/macp.201700597}}, volume = {{219}}, year = {{2018}}, }