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Temperature and pH Controlled Self-Assembly of a Protein-Polymer Biohybrid

Jiang, Lingdong LU ; Bonde, Johan Svensson LU orcid and Ye, Lei LU orcid (2018) In Macromolecular Chemistry and Physics 219(7).
Abstract

A novel pH and temperature dual-responsive bioconjugate is prepared by grafting thermoresponsive polymer chains from a pH-responsive protein amelogenin via atom transfer radical polymerization. To the best of our knowledge, this is the first time that amelogenin is exploited to prepare a hybrid biomaterial with new stimuli-responsive property. In both basic and acidic solutions the protein-polymer bioconjugate is able to self-assemble into uniform and stable nanoparticles when heated to above the lower critical solution temperature of the polymer. The amelogenin-based stimuli-responsive bioconjugate may be of great use in the fields of bioseparation and drug/gene delivery, and the synthetic approach reported here should provide a... (More)

A novel pH and temperature dual-responsive bioconjugate is prepared by grafting thermoresponsive polymer chains from a pH-responsive protein amelogenin via atom transfer radical polymerization. To the best of our knowledge, this is the first time that amelogenin is exploited to prepare a hybrid biomaterial with new stimuli-responsive property. In both basic and acidic solutions the protein-polymer bioconjugate is able to self-assemble into uniform and stable nanoparticles when heated to above the lower critical solution temperature of the polymer. The amelogenin-based stimuli-responsive bioconjugate may be of great use in the fields of bioseparation and drug/gene delivery, and the synthetic approach reported here should provide a convenient means to preparing amelogenin-based functional biohybrid materials.

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Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Amelogenin, Atom transfer radical polymerization, Bioconjugate, Dual-responsive, Self-assembly
in
Macromolecular Chemistry and Physics
volume
219
issue
7
article number
1700597
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85040775023
ISSN
1022-1352
DOI
10.1002/macp.201700597
language
English
LU publication?
yes
id
ef2c9d23-3da9-42bf-985d-8d78cf166dd2
date added to LUP
2018-01-30 13:57:53
date last changed
2025-10-14 11:17:36
@article{ef2c9d23-3da9-42bf-985d-8d78cf166dd2,
  abstract     = {{<p>A novel pH and temperature dual-responsive bioconjugate is prepared by grafting thermoresponsive polymer chains from a pH-responsive protein amelogenin via atom transfer radical polymerization. To the best of our knowledge, this is the first time that amelogenin is exploited to prepare a hybrid biomaterial with new stimuli-responsive property. In both basic and acidic solutions the protein-polymer bioconjugate is able to self-assemble into uniform and stable nanoparticles when heated to above the lower critical solution temperature of the polymer. The amelogenin-based stimuli-responsive bioconjugate may be of great use in the fields of bioseparation and drug/gene delivery, and the synthetic approach reported here should provide a convenient means to preparing amelogenin-based functional biohybrid materials.</p>}},
  author       = {{Jiang, Lingdong and Bonde, Johan Svensson and Ye, Lei}},
  issn         = {{1022-1352}},
  keywords     = {{Amelogenin; Atom transfer radical polymerization; Bioconjugate; Dual-responsive; Self-assembly}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{7}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Macromolecular Chemistry and Physics}},
  title        = {{Temperature and pH Controlled Self-Assembly of a Protein-Polymer Biohybrid}},
  url          = {{http://dx.doi.org/10.1002/macp.201700597}},
  doi          = {{10.1002/macp.201700597}},
  volume       = {{219}},
  year         = {{2018}},
}