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Plasma Alkylresorcinols Reflect Important Whole-Grain Components of a Healthy Nordic Diet

Magnusdottir, Ola Kally ; Landberg, Rikard ; Gunnarsdottir, Ingibjorg ; Cloetens, Lieselotte LU ; Åkesson, Björn LU ; Önning, Gunilla LU ; Jonsdottir, Svandis Erna ; Rosqvist, Fredrik ; Schwab, Ursula and Herzig, Karl-Heinz , et al. (2013) In Journal of Nutrition 143(9). p.1383-1390
Abstract
Biomarkers of dietary intake can be important tools in nutrition research. Our aim was to assess whether plasma alkylresorcinol (AR) and beta-carotene concentrations could be used as dietary biomarkers for whole-grain, fruits and vegetables in a healthy Nordic diet (ND). Participants (n = 166), 30-65 y with a body mass index of 27-40 kg/m(2) and two more features of metabolic syndrome (International Diabetes Federation definition, slightly modified), were recruited through six centers in the Nordic countries and randomly assigned to an ND or control diet for 18 or 24 wk, depending on study center. Plasma AR and beta-carotene were analyzed and nutrient intake calculated from 4-d food records. Median fiber intake increased in the ND group... (More)
Biomarkers of dietary intake can be important tools in nutrition research. Our aim was to assess whether plasma alkylresorcinol (AR) and beta-carotene concentrations could be used as dietary biomarkers for whole-grain, fruits and vegetables in a healthy Nordic diet (ND). Participants (n = 166), 30-65 y with a body mass index of 27-40 kg/m(2) and two more features of metabolic syndrome (International Diabetes Federation definition, slightly modified), were recruited through six centers in the Nordic countries and randomly assigned to an ND or control diet for 18 or 24 wk, depending on study center. Plasma AR and beta-carotene were analyzed and nutrient intake calculated from 4-d food records. Median fiber intake increased in the ND group from 2.5 g/MJ at baseline to 4.1 g/MJ (P < 0.001) at end point (week 18 or 24), and median (IQR) fasting plasma total AR concentration increased from 73 (88) to 106 (108) nmol/L, or 45%, from baseline to end point (P < 0.001). The AR concentration was significantly higher in the ND group (P < 0.001) than in the control group at end point. beta-Carotene intake tended to increase in the ND group (P = 0.07), but the plasma beta-carotene concentration did not change significantly throughout the study and did not differ between the groups at follow-up. In conclusion, an ND resulted in higher dietary fiber intake and increased plasma total AR concentration compared with the control diet, showing that the total AR concentration might be a valid biomarker for an ND in which whole-grain wheat and rye are important components. No significant difference in plasma beta-carotene concentrations was observed between the ND and control groups, suggesting that beta-carotene may not be a sensitive enough biomarker of the ND. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Nutrition
volume
143
issue
9
pages
1383 - 1390
publisher
American Society for Nutrition
external identifiers
  • wos:000323466200004
  • scopus:84883270528
ISSN
1541-6100
DOI
10.3945/jn.113.175588
language
English
LU publication?
yes
id
ef43baab-2003-459e-815d-83cb2fe90a9f (old id 4062860)
date added to LUP
2016-04-01 09:52:08
date last changed
2020-03-24 01:03:32
@article{ef43baab-2003-459e-815d-83cb2fe90a9f,
  abstract     = {Biomarkers of dietary intake can be important tools in nutrition research. Our aim was to assess whether plasma alkylresorcinol (AR) and beta-carotene concentrations could be used as dietary biomarkers for whole-grain, fruits and vegetables in a healthy Nordic diet (ND). Participants (n = 166), 30-65 y with a body mass index of 27-40 kg/m(2) and two more features of metabolic syndrome (International Diabetes Federation definition, slightly modified), were recruited through six centers in the Nordic countries and randomly assigned to an ND or control diet for 18 or 24 wk, depending on study center. Plasma AR and beta-carotene were analyzed and nutrient intake calculated from 4-d food records. Median fiber intake increased in the ND group from 2.5 g/MJ at baseline to 4.1 g/MJ (P &lt; 0.001) at end point (week 18 or 24), and median (IQR) fasting plasma total AR concentration increased from 73 (88) to 106 (108) nmol/L, or 45%, from baseline to end point (P &lt; 0.001). The AR concentration was significantly higher in the ND group (P &lt; 0.001) than in the control group at end point. beta-Carotene intake tended to increase in the ND group (P = 0.07), but the plasma beta-carotene concentration did not change significantly throughout the study and did not differ between the groups at follow-up. In conclusion, an ND resulted in higher dietary fiber intake and increased plasma total AR concentration compared with the control diet, showing that the total AR concentration might be a valid biomarker for an ND in which whole-grain wheat and rye are important components. No significant difference in plasma beta-carotene concentrations was observed between the ND and control groups, suggesting that beta-carotene may not be a sensitive enough biomarker of the ND.},
  author       = {Magnusdottir, Ola Kally and Landberg, Rikard and Gunnarsdottir, Ingibjorg and Cloetens, Lieselotte and Åkesson, Björn and Önning, Gunilla and Jonsdottir, Svandis Erna and Rosqvist, Fredrik and Schwab, Ursula and Herzig, Karl-Heinz and Savolainen, Markku J. and Brader, Lea and Hermansen, Kjeld and Kolehmainen, Marjukka and Poutanen, Kaisa and Uusitupa, Matti and Thorsdottir, Inga and Riserus, Ulf},
  issn         = {1541-6100},
  language     = {eng},
  number       = {9},
  pages        = {1383--1390},
  publisher    = {American Society for Nutrition},
  series       = {Journal of Nutrition},
  title        = {Plasma Alkylresorcinols Reflect Important Whole-Grain Components of a Healthy Nordic Diet},
  url          = {http://dx.doi.org/10.3945/jn.113.175588},
  doi          = {10.3945/jn.113.175588},
  volume       = {143},
  year         = {2013},
}