Endoplasmic reticulum dynamics in hippocampal dendritic spines induced by agonists of type I metabotropic glutamate but not by muscarinic acetylcholine receptors.
(2011) In Synapse 65(4). p.351-355- Abstract
- Neurons in the hippocampus exhibit subpopulations of dendritic spines that contain endoplasmic reticulum (ER). ER in spines is important for synaptic activity and its associated Ca(2+) signaling. The dynamic distribution of ER to spines is regulated by diacylglycerol and partly mediated by protein kinase C, metalloproteinases and γ-secretase. In this study, we explored whether pharmacological activation of type I metabotropic glutamate receptors (mGluRs) and muscarinic acetylcholine receptors (mAChRs) known to activate phospholipase C would have any effect on spine ER content. We found that DHPG (100 μM) but not carbachol (10 μM) caused a reduction in the number of spines with ER. We further found that ER Ca(2+) depletion triggered by... (More)
- Neurons in the hippocampus exhibit subpopulations of dendritic spines that contain endoplasmic reticulum (ER). ER in spines is important for synaptic activity and its associated Ca(2+) signaling. The dynamic distribution of ER to spines is regulated by diacylglycerol and partly mediated by protein kinase C, metalloproteinases and γ-secretase. In this study, we explored whether pharmacological activation of type I metabotropic glutamate receptors (mGluRs) and muscarinic acetylcholine receptors (mAChRs) known to activate phospholipase C would have any effect on spine ER content. We found that DHPG (100 μM) but not carbachol (10 μM) caused a reduction in the number of spines with ER. We further found that ER Ca(2+) depletion triggered by thapsigargin (200 nM) had no effect on ER localization in spines. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1832407
- author
- Ng, Ai Na LU and Toresson, Håkan LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Synapse
- volume
- 65
- issue
- 4
- pages
- 351 - 355
- publisher
- Wiley
- external identifiers
-
- wos:000287614000010
- pmid:21284010
- scopus:79251569260
- pmid:21284010
- ISSN
- 1098-2396
- DOI
- 10.1002/syn.20887
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Laboratory for Experimental Brain Research (013041000)
- id
- ef543bf6-9c8b-4f54-94fe-1e77a1cef9bc (old id 1832407)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21284010?dopt=Abstract
- date added to LUP
- 2016-04-04 08:56:29
- date last changed
- 2022-09-06 22:58:50
@article{ef543bf6-9c8b-4f54-94fe-1e77a1cef9bc,
abstract = {{Neurons in the hippocampus exhibit subpopulations of dendritic spines that contain endoplasmic reticulum (ER). ER in spines is important for synaptic activity and its associated Ca(2+) signaling. The dynamic distribution of ER to spines is regulated by diacylglycerol and partly mediated by protein kinase C, metalloproteinases and γ-secretase. In this study, we explored whether pharmacological activation of type I metabotropic glutamate receptors (mGluRs) and muscarinic acetylcholine receptors (mAChRs) known to activate phospholipase C would have any effect on spine ER content. We found that DHPG (100 μM) but not carbachol (10 μM) caused a reduction in the number of spines with ER. We further found that ER Ca(2+) depletion triggered by thapsigargin (200 nM) had no effect on ER localization in spines.}},
author = {{Ng, Ai Na and Toresson, Håkan}},
issn = {{1098-2396}},
language = {{eng}},
number = {{4}},
pages = {{351--355}},
publisher = {{Wiley}},
series = {{Synapse}},
title = {{Endoplasmic reticulum dynamics in hippocampal dendritic spines induced by agonists of type I metabotropic glutamate but not by muscarinic acetylcholine receptors.}},
url = {{http://dx.doi.org/10.1002/syn.20887}},
doi = {{10.1002/syn.20887}},
volume = {{65}},
year = {{2011}},
}