Increased cancer risk in families with pediatric cancer is associated with gender, age, diagnosis, and degree of relation to the child
(2020) In Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 29(11). p.2171-2179- Abstract
BACKGROUND: Studies of cancer risk among relatives of children with cancer beyond parents and siblings are limited. We have investigated the cancer risk up to the third degree of relation in families with pediatric cancer to reveal patterns of inheritance.
METHODS: A single-center cohort of 757 pediatric cancer patients was linked to the Swedish National Population Register, resulting in 16 137 relatives up to the third degree of relation. All relatives were matched to the Swedish Cancer Register and standard incidence ratios (SIRs) were calculated to define relatives at risk.
RESULTS: Children and adults up to the third degree of relation had increased cancer risk, with SIRs of 1.48 (P=0.01) and 1.07 (P<0.01),... (More)
BACKGROUND: Studies of cancer risk among relatives of children with cancer beyond parents and siblings are limited. We have investigated the cancer risk up to the third degree of relation in families with pediatric cancer to reveal patterns of inheritance.
METHODS: A single-center cohort of 757 pediatric cancer patients was linked to the Swedish National Population Register, resulting in 16 137 relatives up to the third degree of relation. All relatives were matched to the Swedish Cancer Register and standard incidence ratios (SIRs) were calculated to define relatives at risk.
RESULTS: Children and adults up to the third degree of relation had increased cancer risk, with SIRs of 1.48 (P=0.01) and 1.07 (P<0.01), respectively. The SIRs for first- and third-degree adult relatives were 1.22 and 1.10, respectively, but no increased risk was observed in second-degree relatives. Male relatives had a higher risk than females, especially when related to a girl and when the child had leukemia. The risk was mainly increased for lung, prostate and gastrointestinal cancer. When excluding 29 families of children with known pathogenic germline variants, the increased risk remained.
CONCLUSION: Relatives to children with cancer up to third degree of relation have an increased cancer risk. Known pathogenic germline variants do not explain this increased risk.
IMPACT: The overall increased cancer risk among relatives of children with cancer in this population-based cohort strengthens the importance of surveillance programs for families with pediatric cancer.
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- author
- Stjernfelt, Karl-Johan LU ; von Stedingk, Kristoffer LU ; Wiebe, Thomas LU ; Hjorth, Lars LU ; Kristoffersson, Ulf LU ; Stenmark-Askmalm, Marie LU ; Olsson, Håkan LU and Øra, Ingrid LU
- organization
-
- Childhood Cancer Research Unit (research group)
- Paediatrics (Lund)
- LUCC: Lund University Cancer Centre
- Late effects after childhood cancer treatment (research group)
- Division of Clinical Genetics
- Biomarkers and epidemiology
- Lund Melanoma Study Group (research group)
- EpiHealth: Epidemiology for Health
- Pathways of cancer cell evolution (research group)
- publishing date
- 2020-11
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
- volume
- 29
- issue
- 11
- pages
- 9 pages
- publisher
- American Association for Cancer Research
- external identifiers
-
- scopus:85102197170
- pmid:32856606
- ISSN
- 1538-7755
- DOI
- 10.1158/1055-9965.EPI-20-0322
- project
- Cancer risk and predisposition in families with childhood cancer
- language
- English
- LU publication?
- yes
- additional info
- Copyright ©2020, American Association for Cancer Research.
- id
- efc25c11-19ca-4bb7-a880-eaabfaf059e7
- date added to LUP
- 2020-09-05 00:14:01
- date last changed
- 2024-03-20 16:04:31
@article{efc25c11-19ca-4bb7-a880-eaabfaf059e7, abstract = {{<p>BACKGROUND: Studies of cancer risk among relatives of children with cancer beyond parents and siblings are limited. We have investigated the cancer risk up to the third degree of relation in families with pediatric cancer to reveal patterns of inheritance.</p><p>METHODS: A single-center cohort of 757 pediatric cancer patients was linked to the Swedish National Population Register, resulting in 16 137 relatives up to the third degree of relation. All relatives were matched to the Swedish Cancer Register and standard incidence ratios (SIRs) were calculated to define relatives at risk.</p><p>RESULTS: Children and adults up to the third degree of relation had increased cancer risk, with SIRs of 1.48 (P=0.01) and 1.07 (P<0.01), respectively. The SIRs for first- and third-degree adult relatives were 1.22 and 1.10, respectively, but no increased risk was observed in second-degree relatives. Male relatives had a higher risk than females, especially when related to a girl and when the child had leukemia. The risk was mainly increased for lung, prostate and gastrointestinal cancer. When excluding 29 families of children with known pathogenic germline variants, the increased risk remained.</p><p>CONCLUSION: Relatives to children with cancer up to third degree of relation have an increased cancer risk. Known pathogenic germline variants do not explain this increased risk.</p><p>IMPACT: The overall increased cancer risk among relatives of children with cancer in this population-based cohort strengthens the importance of surveillance programs for families with pediatric cancer.</p>}}, author = {{Stjernfelt, Karl-Johan and von Stedingk, Kristoffer and Wiebe, Thomas and Hjorth, Lars and Kristoffersson, Ulf and Stenmark-Askmalm, Marie and Olsson, Håkan and Øra, Ingrid}}, issn = {{1538-7755}}, language = {{eng}}, number = {{11}}, pages = {{2171--2179}}, publisher = {{American Association for Cancer Research}}, series = {{Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology}}, title = {{Increased cancer risk in families with pediatric cancer is associated with gender, age, diagnosis, and degree of relation to the child}}, url = {{http://dx.doi.org/10.1158/1055-9965.EPI-20-0322}}, doi = {{10.1158/1055-9965.EPI-20-0322}}, volume = {{29}}, year = {{2020}}, }