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Increased cancer risk in families with pediatric cancer is associated with gender, age, diagnosis, and degree of relation to the child

Stjernfelt, Karl-Johan LU ; von Stedingk, Kristoffer LU ; Wiebe, Thomas LU ; Hjorth, Lars LU ; Kristoffersson, Ulf LU ; Stenmark-Askmalm, Marie LU ; Olsson, Håkan LU orcid and Øra, Ingrid LU (2020) In Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 29(11). p.2171-2179
Abstract

BACKGROUND: Studies of cancer risk among relatives of children with cancer beyond parents and siblings are limited. We have investigated the cancer risk up to the third degree of relation in families with pediatric cancer to reveal patterns of inheritance.

METHODS: A single-center cohort of 757 pediatric cancer patients was linked to the Swedish National Population Register, resulting in 16 137 relatives up to the third degree of relation. All relatives were matched to the Swedish Cancer Register and standard incidence ratios (SIRs) were calculated to define relatives at risk.

RESULTS: Children and adults up to the third degree of relation had increased cancer risk, with SIRs of 1.48 (P=0.01) and 1.07 (P<0.01),... (More)

BACKGROUND: Studies of cancer risk among relatives of children with cancer beyond parents and siblings are limited. We have investigated the cancer risk up to the third degree of relation in families with pediatric cancer to reveal patterns of inheritance.

METHODS: A single-center cohort of 757 pediatric cancer patients was linked to the Swedish National Population Register, resulting in 16 137 relatives up to the third degree of relation. All relatives were matched to the Swedish Cancer Register and standard incidence ratios (SIRs) were calculated to define relatives at risk.

RESULTS: Children and adults up to the third degree of relation had increased cancer risk, with SIRs of 1.48 (P=0.01) and 1.07 (P<0.01), respectively. The SIRs for first- and third-degree adult relatives were 1.22 and 1.10, respectively, but no increased risk was observed in second-degree relatives. Male relatives had a higher risk than females, especially when related to a girl and when the child had leukemia. The risk was mainly increased for lung, prostate and gastrointestinal cancer. When excluding 29 families of children with known pathogenic germline variants, the increased risk remained.

CONCLUSION: Relatives to children with cancer up to third degree of relation have an increased cancer risk. Known pathogenic germline variants do not explain this increased risk.

IMPACT: The overall increased cancer risk among relatives of children with cancer in this population-based cohort strengthens the importance of surveillance programs for families with pediatric cancer.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
volume
29
issue
11
pages
9 pages
publisher
American Association for Cancer Research
external identifiers
  • scopus:85102197170
  • pmid:32856606
ISSN
1538-7755
DOI
10.1158/1055-9965.EPI-20-0322
project
Cancer risk and predisposition in families with childhood cancer
language
English
LU publication?
yes
additional info
Copyright ©2020, American Association for Cancer Research.
id
efc25c11-19ca-4bb7-a880-eaabfaf059e7
date added to LUP
2020-09-05 00:14:01
date last changed
2024-03-20 16:04:31
@article{efc25c11-19ca-4bb7-a880-eaabfaf059e7,
  abstract     = {{<p>BACKGROUND: Studies of cancer risk among relatives of children with cancer beyond parents and siblings are limited. We have investigated the cancer risk up to the third degree of relation in families with pediatric cancer to reveal patterns of inheritance.</p><p>METHODS: A single-center cohort of 757 pediatric cancer patients was linked to the Swedish National Population Register, resulting in 16 137 relatives up to the third degree of relation. All relatives were matched to the Swedish Cancer Register and standard incidence ratios (SIRs) were calculated to define relatives at risk.</p><p>RESULTS: Children and adults up to the third degree of relation had increased cancer risk, with SIRs of 1.48 (P=0.01) and 1.07 (P&lt;0.01), respectively. The SIRs for first- and third-degree adult relatives were 1.22 and 1.10, respectively, but no increased risk was observed in second-degree relatives. Male relatives had a higher risk than females, especially when related to a girl and when the child had leukemia. The risk was mainly increased for lung, prostate and gastrointestinal cancer. When excluding 29 families of children with known pathogenic germline variants, the increased risk remained.</p><p>CONCLUSION: Relatives to children with cancer up to third degree of relation have an increased cancer risk. Known pathogenic germline variants do not explain this increased risk.</p><p>IMPACT: The overall increased cancer risk among relatives of children with cancer in this population-based cohort strengthens the importance of surveillance programs for families with pediatric cancer.</p>}},
  author       = {{Stjernfelt, Karl-Johan and von Stedingk, Kristoffer and Wiebe, Thomas and Hjorth, Lars and Kristoffersson, Ulf and Stenmark-Askmalm, Marie and Olsson, Håkan and Øra, Ingrid}},
  issn         = {{1538-7755}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{2171--2179}},
  publisher    = {{American Association for Cancer Research}},
  series       = {{Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology}},
  title        = {{Increased cancer risk in families with pediatric cancer is associated with gender, age, diagnosis, and degree of relation to the child}},
  url          = {{http://dx.doi.org/10.1158/1055-9965.EPI-20-0322}},
  doi          = {{10.1158/1055-9965.EPI-20-0322}},
  volume       = {{29}},
  year         = {{2020}},
}