Signal transduction via the stem cell factor receptor/c-Kit.
Rönnstrand, Lars LU
(2004)
In Cellular and Molecular Life Sciences
61(19-20).
p.2535-2548
- Abstract
- Together with its ligand, stem cell factor, the receptor tyrosine kinase c-Kit is a key controlling receptor for a number of cell types, including hematopoietic stem cells, mast cells, melanocytes and germ cells. Gain-of-function mutations in c-Kit have been described in a number of human cancers, including testicular germinomas, acute myeloid leukemia and gastrointestinal stromal tumors.
Stimulation of c-Kit by its ligand leads to dimerization of receptors, activation of its intrinsic tyrosine kinase activity and phosphorylation of key tyrosine residues within the receptor. These phosphorylated tyrosine residues serve as docking sites for a number of signal transduction molecules containing Src homology 2 domains, which will... (More) - Together with its ligand, stem cell factor, the receptor tyrosine kinase c-Kit is a key controlling receptor for a number of cell types, including hematopoietic stem cells, mast cells, melanocytes and germ cells. Gain-of-function mutations in c-Kit have been described in a number of human cancers, including testicular germinomas, acute myeloid leukemia and gastrointestinal stromal tumors.
Stimulation of c-Kit by its ligand leads to dimerization of receptors, activation of its intrinsic tyrosine kinase activity and phosphorylation of key tyrosine residues within the receptor. These phosphorylated tyrosine residues serve as docking sites for a number of signal transduction molecules containing Src homology 2 domains, which will thereby be recruited to the receptor and activated many times through phosphorylation by the receptor. This review discusses our current knowledge of signal transduction molecules and signal transduction pathways activated by c-Kit and how their activation can be connected to the physiological outcome of c-Kit signaling. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/130962
- author
- Rönnstrand, Lars
LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cellular and Molecular Life Sciences
- volume
- 61
- issue
- 19-20
- pages
- 2535 - 2548
- publisher
- Birkhäuser Verlag
- external identifiers
-
- wos:000224888600012
- scopus:9744246909
- ISSN
- 1420-9071
- DOI
- 10.1007/s00018-004-4189-6
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Experimental Clinical Chemistry (013016010)
- id
- efc8642d-c784-4124-960c-8e79d10813ad (old id 130962)
- date added to LUP
- 2016-04-01 16:37:27
- date last changed
- 2022-04-22 23:23:28
@article{efc8642d-c784-4124-960c-8e79d10813ad,
abstract = {{Together with its ligand, stem cell factor, the receptor tyrosine kinase c-Kit is a key controlling receptor for a number of cell types, including hematopoietic stem cells, mast cells, melanocytes and germ cells. Gain-of-function mutations in c-Kit have been described in a number of human cancers, including testicular germinomas, acute myeloid leukemia and gastrointestinal stromal tumors.<br/><br>
Stimulation of c-Kit by its ligand leads to dimerization of receptors, activation of its intrinsic tyrosine kinase activity and phosphorylation of key tyrosine residues within the receptor. These phosphorylated tyrosine residues serve as docking sites for a number of signal transduction molecules containing Src homology 2 domains, which will thereby be recruited to the receptor and activated many times through phosphorylation by the receptor. This review discusses our current knowledge of signal transduction molecules and signal transduction pathways activated by c-Kit and how their activation can be connected to the physiological outcome of c-Kit signaling.}},
author = {{Rönnstrand, Lars}},
issn = {{1420-9071}},
language = {{eng}},
number = {{19-20}},
pages = {{2535--2548}},
publisher = {{Birkhäuser Verlag}},
series = {{Cellular and Molecular Life Sciences}},
title = {{Signal transduction via the stem cell factor receptor/c-Kit.}},
url = {{http://dx.doi.org/10.1007/s00018-004-4189-6}},
doi = {{10.1007/s00018-004-4189-6}},
volume = {{61}},
year = {{2004}},
}