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Meta-Analysis Investigating Associations Between Healthy Diet and Fasting Glucose and Insulin Levels and Modification by Loci Associated With Glucose Homeostasis in Data From 15 Cohorts

Nettleton, Jennifer A. ; Hivert, Marie-France ; Lemaitre, Rozenn N. ; McKeown, Nicola M. ; Mozaffarian, Dariush ; Tanaka, Toshiko ; Wojczynski, Mary K. ; Hruby, Adela ; Djousse, Luc and Ngwa, Julius S. , et al. (2013) In American Journal of Epidemiology 177(2). p.103-115
Abstract
Whether loci that influence fasting glucose (FG) and fasting insulin (FI) levels, as identified by genome-wide association studies, modify associations of diet with FG or FI is unknown. We utilized data from 15 US and European cohort studies comprising 51,289 persons without diabetes to test whether genotype and diet interact to influence FG or FI concentration. We constructed a diet score using study-specific quartile rankings for intakes of whole grains, fish, fruits, vegetables, and nuts/seeds (favorable) and red/processed meats, sweets, sugared beverages, and fried potatoes (unfavorable). We used linear regression within studies, followed by inverse-variance-weighted meta-analysis, to quantify 1) associations of diet score with FG and... (More)
Whether loci that influence fasting glucose (FG) and fasting insulin (FI) levels, as identified by genome-wide association studies, modify associations of diet with FG or FI is unknown. We utilized data from 15 US and European cohort studies comprising 51,289 persons without diabetes to test whether genotype and diet interact to influence FG or FI concentration. We constructed a diet score using study-specific quartile rankings for intakes of whole grains, fish, fruits, vegetables, and nuts/seeds (favorable) and red/processed meats, sweets, sugared beverages, and fried potatoes (unfavorable). We used linear regression within studies, followed by inverse-variance-weighted meta-analysis, to quantify 1) associations of diet score with FG and FI levels and 2) interactions of diet score with 16 FG-associated loci and 2 FI-associated loci. Diet score (per unit increase) was inversely associated with FG ( 0.004 mmol/L, 95 confidence interval: 0.005, 0.003) and FI ( 0.008 ln-pmol/L, 95 confidence interval: 0.009, 0.007) levels after adjustment for demographic factors, lifestyle, and body mass index. Genotype variation at the studied loci did not modify these associations. Healthier diets were associated with lower FG and FI concentrations regardless of genotype at previously replicated FG- and FI-associated loci. Studies focusing on genomic regions that do not yield highly statistically significant associations from main-effect genome-wide association studies may be more fruitful in identifying diet-gene interactions. (Less)
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publication status
published
subject
keywords
diabetes, dietary pattern, gene-environment interaction, glucose, insulin
in
American Journal of Epidemiology
volume
177
issue
2
pages
103 - 115
publisher
Oxford University Press
external identifiers
  • wos:000313528700001
  • scopus:84872232296
  • pmid:23255780
ISSN
0002-9262
DOI
10.1093/aje/kws297
language
English
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yes
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efcab368-f83b-4bc5-861f-53bffc0f9bff (old id 3470537)
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2016-04-01 10:06:22
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2020-01-07 01:40:04
@article{efcab368-f83b-4bc5-861f-53bffc0f9bff,
  abstract     = {Whether loci that influence fasting glucose (FG) and fasting insulin (FI) levels, as identified by genome-wide association studies, modify associations of diet with FG or FI is unknown. We utilized data from 15 US and European cohort studies comprising 51,289 persons without diabetes to test whether genotype and diet interact to influence FG or FI concentration. We constructed a diet score using study-specific quartile rankings for intakes of whole grains, fish, fruits, vegetables, and nuts/seeds (favorable) and red/processed meats, sweets, sugared beverages, and fried potatoes (unfavorable). We used linear regression within studies, followed by inverse-variance-weighted meta-analysis, to quantify 1) associations of diet score with FG and FI levels and 2) interactions of diet score with 16 FG-associated loci and 2 FI-associated loci. Diet score (per unit increase) was inversely associated with FG ( 0.004 mmol/L, 95 confidence interval: 0.005, 0.003) and FI ( 0.008 ln-pmol/L, 95 confidence interval: 0.009, 0.007) levels after adjustment for demographic factors, lifestyle, and body mass index. Genotype variation at the studied loci did not modify these associations. Healthier diets were associated with lower FG and FI concentrations regardless of genotype at previously replicated FG- and FI-associated loci. Studies focusing on genomic regions that do not yield highly statistically significant associations from main-effect genome-wide association studies may be more fruitful in identifying diet-gene interactions.},
  author       = {Nettleton, Jennifer A. and Hivert, Marie-France and Lemaitre, Rozenn N. and McKeown, Nicola M. and Mozaffarian, Dariush and Tanaka, Toshiko and Wojczynski, Mary K. and Hruby, Adela and Djousse, Luc and Ngwa, Julius S. and Follis, Jack L. and Dimitriou, Maria and Ganna, Andrea and Houston, Denise K. and Kanoni, Stavroula and Mikkila, Vera and Manichaikul, Ani and Ntalla, Ioanna and Renström, Frida and Sonestedt, Emily and van Rooij, Frank J. A. and Bandinelli, Stefania and de Koning, Lawrence and Ericson, Ulrika and Hassanali, Neelam and Kiefte-de Jong, Jessica C. and Lohman, Kurt K. and Raitakari, Olli and Papoutsakis, Constantina and Sjogren, Per and Stirrups, Kathleen and Ax, Erika and Deloukas, Panos and Groves, Christopher J. and Jacques, Paul F. and Johansson, Ingegerd and Liu, Yongmei and McCarthy, Mark I. and North, Kari and Viikari, Jorma and Zillikens, M. Carola and Dupuis, Josee and Hofman, Albert and Kolovou, Genovefa and Mukamal, Kenneth and Prokopenko, Inga and Rolandsson, Olov and Seppala, Ilkka and Cupples, L. Adrienne and Hu, Frank B. and Kahonen, Mika and Uitterlinden, Andre G. and Borecki, Ingrid B. and Ferrucci, Luigi and Jacobs, David R. Jr. and Kritchevsky, Stephen B. and Orho-Melander, Marju and Pankow, James S. and Lehtimaki, Terho and Witteman, Jacqueline C. M. and Ingelsson, Erik and Siscovick, David S. and Dedoussis, George and Meigs, James B. and Franks, Paul},
  issn         = {0002-9262},
  language     = {eng},
  number       = {2},
  pages        = {103--115},
  publisher    = {Oxford University Press},
  series       = {American Journal of Epidemiology},
  title        = {Meta-Analysis Investigating Associations Between Healthy Diet and Fasting Glucose and Insulin Levels and Modification by Loci Associated With Glucose Homeostasis in Data From 15 Cohorts},
  url          = {http://dx.doi.org/10.1093/aje/kws297},
  doi          = {10.1093/aje/kws297},
  volume       = {177},
  year         = {2013},
}