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Next-generation sequencing for viruses in children with rapid-onset type 1 diabetes

Lee, H-S; Briese, T.; Winkler, C.; Rewers, M.; Bonifacio, E.; Hyoty, H.; Pflueger, M.; Simell, O.; She, J. X. and Hagopian, W., et al. (2013) In Diabetologia 56(8). p.1705-1711
Abstract
Viruses are candidate causative agents in the pathogenesis of autoimmune (type 1) diabetes. We hypothesised that children with a rapid onset of type 1 diabetes may have been exposed to such agents shortly before the initiation of islet autoimmunity, possibly at high dose, and thus study of these children could help identify viruses involved in the development of autoimmune diabetes. We used next-generation sequencing to search for viruses in plasma samples and examined the history of infection and fever in children enrolled in The Environmental Determinants of Diabetes in the Young (TEDDY) study who progressed to type 1 diabetes within 6 months from the appearance of islet autoimmunity, and in matched islet-autoantibody-negative controls.... (More)
Viruses are candidate causative agents in the pathogenesis of autoimmune (type 1) diabetes. We hypothesised that children with a rapid onset of type 1 diabetes may have been exposed to such agents shortly before the initiation of islet autoimmunity, possibly at high dose, and thus study of these children could help identify viruses involved in the development of autoimmune diabetes. We used next-generation sequencing to search for viruses in plasma samples and examined the history of infection and fever in children enrolled in The Environmental Determinants of Diabetes in the Young (TEDDY) study who progressed to type 1 diabetes within 6 months from the appearance of islet autoimmunity, and in matched islet-autoantibody-negative controls. Viruses were not detected more frequently in plasma from rapid-onset patients than in controls during the period surrounding seroconversion. In addition, infection histories were found to be similar between children with rapid-onset diabetes and control children, although episodes of fever were reported less frequently in children with rapid-onset diabetes. These findings do not support the presence of viraemia around the time of seroconversion in young children with rapid-onset type 1 diabetes. (Less)
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keywords
GB virus C, Human herpes virus 6, Human rhinovirus C, Infections, Islet, autoimmunity, Next-generation deep sequencing, Parvovirus B19, TEDDY, study, Type 1 diabetes mellitus
in
Diabetologia
volume
56
issue
8
pages
1705 - 1711
publisher
Springer
external identifiers
  • wos:000321285400005
  • scopus:84879939221
ISSN
1432-0428
DOI
10.1007/s00125-013-2924-y
language
English
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yes
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efe9720c-3000-49ab-a61d-bcc1a70afe56 (old id 3975476)
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2013-09-02 07:36:11
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2019-03-19 01:17:24
@article{efe9720c-3000-49ab-a61d-bcc1a70afe56,
  abstract     = {Viruses are candidate causative agents in the pathogenesis of autoimmune (type 1) diabetes. We hypothesised that children with a rapid onset of type 1 diabetes may have been exposed to such agents shortly before the initiation of islet autoimmunity, possibly at high dose, and thus study of these children could help identify viruses involved in the development of autoimmune diabetes. We used next-generation sequencing to search for viruses in plasma samples and examined the history of infection and fever in children enrolled in The Environmental Determinants of Diabetes in the Young (TEDDY) study who progressed to type 1 diabetes within 6 months from the appearance of islet autoimmunity, and in matched islet-autoantibody-negative controls. Viruses were not detected more frequently in plasma from rapid-onset patients than in controls during the period surrounding seroconversion. In addition, infection histories were found to be similar between children with rapid-onset diabetes and control children, although episodes of fever were reported less frequently in children with rapid-onset diabetes. These findings do not support the presence of viraemia around the time of seroconversion in young children with rapid-onset type 1 diabetes.},
  author       = {Lee, H-S and Briese, T. and Winkler, C. and Rewers, M. and Bonifacio, E. and Hyoty, H. and Pflueger, M. and Simell, O. and She, J. X. and Hagopian, W. and Lernmark, Åke and Akolkar, B. and Krischer, J. P. and Ziegler, A. G.},
  issn         = {1432-0428},
  keyword      = {GB virus C,Human herpes virus 6,Human rhinovirus C,Infections,Islet,autoimmunity,Next-generation deep sequencing,Parvovirus B19,TEDDY,study,Type 1 diabetes mellitus},
  language     = {eng},
  number       = {8},
  pages        = {1705--1711},
  publisher    = {Springer},
  series       = {Diabetologia},
  title        = {Next-generation sequencing for viruses in children with rapid-onset type 1 diabetes},
  url          = {http://dx.doi.org/10.1007/s00125-013-2924-y},
  volume       = {56},
  year         = {2013},
}