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Proteome

Westergren-Thorsson, G. LU ; Marko-Varga, G. LU ; Malmström, J. LU and Larsen, K. LU (2006) p.527-532
Abstract

Proteomics can be defined as the studies of protein properties on a large scale to obtain a global view of biological processes at the protein level. Essentially, proteomics requires protein separation and identification, and in many cases quantification. The cornerstones in proteomics are protein/peptide separation by gel electrophoresis and/or different chromatographic techniques, and identification by mass spectrometry followed by bioinformatic and biological interpretation of data. By combining these different separation techniques and mass spectrometry it is now possible to identify low abundant proteins with 10-1000 copies per cell. Today, substantial research efforts in proteome studies of the lung are focused on obtaining new... (More)

Proteomics can be defined as the studies of protein properties on a large scale to obtain a global view of biological processes at the protein level. Essentially, proteomics requires protein separation and identification, and in many cases quantification. The cornerstones in proteomics are protein/peptide separation by gel electrophoresis and/or different chromatographic techniques, and identification by mass spectrometry followed by bioinformatic and biological interpretation of data. By combining these different separation techniques and mass spectrometry it is now possible to identify low abundant proteins with 10-1000 copies per cell. Today, substantial research efforts in proteome studies of the lung are focused on obtaining new diagnostic markers, as well as fingerprinting disease mechanisms.

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author
; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Bioinformatics, Broncheoalveolar lavage, Fibroblasts, Gel electrophoresis, Gene ontology, Lung, Mass spectrometry, Peptides, Protein, Proteome
host publication
Encyclopedia of Respiratory Medicine, Four-Volume Set
pages
527 - 532
publisher
Elsevier Inc.
external identifiers
  • scopus:85069288531
ISBN
9780123708793
DOI
10.1016/B0-12-370879-6/00331-8
language
English
LU publication?
yes
id
f0037d59-bf4d-46db-9e06-1fc5b18a5974
date added to LUP
2019-12-26 11:46:34
date last changed
2020-01-13 02:37:29
@inbook{f0037d59-bf4d-46db-9e06-1fc5b18a5974,
  abstract     = {<p>Proteomics can be defined as the studies of protein properties on a large scale to obtain a global view of biological processes at the protein level. Essentially, proteomics requires protein separation and identification, and in many cases quantification. The cornerstones in proteomics are protein/peptide separation by gel electrophoresis and/or different chromatographic techniques, and identification by mass spectrometry followed by bioinformatic and biological interpretation of data. By combining these different separation techniques and mass spectrometry it is now possible to identify low abundant proteins with 10-1000 copies per cell. Today, substantial research efforts in proteome studies of the lung are focused on obtaining new diagnostic markers, as well as fingerprinting disease mechanisms.</p>},
  author       = {Westergren-Thorsson, G. and Marko-Varga, G. and Malmström, J. and Larsen, K.},
  booktitle    = {Encyclopedia of Respiratory Medicine, Four-Volume Set},
  isbn         = {9780123708793},
  language     = {eng},
  month        = {01},
  pages        = {527--532},
  publisher    = {Elsevier Inc.},
  title        = {Proteome},
  url          = {http://dx.doi.org/10.1016/B0-12-370879-6/00331-8},
  doi          = {10.1016/B0-12-370879-6/00331-8},
  year         = {2006},
}