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Integrated acoustic sample preparation for rapid sepsis diagnostics

Petersson, Klara LU ; Evander, Mikael LU ; Ohlsson, Pelle LU orcid ; Soikkeli, Minna ; Seppä, Titta ; Lehmusvuori, Ari ; Tuunainen, Emilia ; Spangar, Anni ; Karhunen, Ulla and Wittfooth, Saara , et al. (2014) 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 p.294-296
Abstract

We present a novel, integrated microfluidic system based on acoustophoretic cell-handling that detects bacteria in whole blood in less than 2 hours, substantially faster than current standard methods for detection of sepsis-causing bacteria. Bacteria are acoustically separated from 1 ml blood, enriched by acoustic trapping and finally detected using a dry-reagent PCR-chip.

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author
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organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Acoustic separation, Acoustic trapping, Bacteria, Blood, Integrated, PCR, Sepsis
host publication
18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
pages
3 pages
publisher
Chemical and Biological Microsystems Society
conference name
18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
conference location
San Antonio, United States
conference dates
2014-10-26 - 2014-10-30
external identifiers
  • scopus:84941623540
ISBN
9781634396974
9780979806476
language
English
LU publication?
yes
id
f003b2c3-3ec8-413c-a67f-91a2594ab229
date added to LUP
2017-12-06 15:08:51
date last changed
2025-01-08 02:04:36
@inproceedings{f003b2c3-3ec8-413c-a67f-91a2594ab229,
  abstract     = {{<p>We present a novel, integrated microfluidic system based on acoustophoretic cell-handling that detects bacteria in whole blood in less than 2 hours, substantially faster than current standard methods for detection of sepsis-causing bacteria. Bacteria are acoustically separated from 1 ml blood, enriched by acoustic trapping and finally detected using a dry-reagent PCR-chip.</p>}},
  author       = {{Petersson, Klara and Evander, Mikael and Ohlsson, Pelle and Soikkeli, Minna and Seppä, Titta and Lehmusvuori, Ari and Tuunainen, Emilia and Spangar, Anni and Karhunen, Ulla and Wittfooth, Saara and Laurell, Thomas}},
  booktitle    = {{18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014}},
  isbn         = {{9781634396974}},
  keywords     = {{Acoustic separation; Acoustic trapping; Bacteria; Blood; Integrated; PCR; Sepsis}},
  language     = {{eng}},
  pages        = {{294--296}},
  publisher    = {{Chemical and Biological Microsystems Society}},
  title        = {{Integrated acoustic sample preparation for rapid sepsis diagnostics}},
  year         = {{2014}},
}