Cystatin C modulates neurodegeneration and neurogenesis following status epilepticus in mouse
Pirttila, T J ; Lukasiuk, K ; Håkansson, Katarina LU ; Grubb, Anders LU
; Abrahamson, Magnus
LU
and Pitkanen, A
(2005)
In Neurobiology of Disease
20(2).
p.241-253
- Abstract
- Brain damaging insults cause alterations in neuronal networks that trigger epileptogenesis, and eventually lead to the appearance of spontaneous seizures. The present experiments were designed to study the cellular expression and functions of a cysteine proteinase inhibitor, cystatin C, whose gene expression is previously shown to be upregulated in the rat hippocampus during status epilepticus (SE)induced epileptogenesis. The present data showed that the expression of cystatin C protein increased in the mouse hippocampus 7 days following SE and localized mainly to astrocytes and microglia. Acute neuronal death in the hippocampus at 24 h after SE was reduced in cystatin C-/- mice. Also, the basal level of neurogenesis in the subgranular... (More)
- Brain damaging insults cause alterations in neuronal networks that trigger epileptogenesis, and eventually lead to the appearance of spontaneous seizures. The present experiments were designed to study the cellular expression and functions of a cysteine proteinase inhibitor, cystatin C, whose gene expression is previously shown to be upregulated in the rat hippocampus during status epilepticus (SE)induced epileptogenesis. The present data showed that the expression of cystatin C protein increased in the mouse hippocampus 7 days following SE and localized mainly to astrocytes and microglia. Acute neuronal death in the hippocampus at 24 h after SE was reduced in cystatin C-/- mice. Also, the basal level of neurogenesis in the subgranular layer of dentate gyros was decreased in cystatin C-/- mice compared to wildtype littermates. Interestingly, migration of newly born neurons within the granule cell layer was attenuated in cystatin C-/- mice. These data demonstrate that cystatin C has a role in neuronal death and neurogenesis during SE-induced network reorganization. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/213780
- author
- Pirttila, T J
; Lukasiuk, K
; Håkansson, Katarina
LU
; Grubb, Anders
LU
; Abrahamson, Magnus
LU
and Pitkanen, A
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- neural stem cells, mice, knock-out, kainic acid, hippocampus, FGF-2, epileptogenesis, epilepsy, neurodegeneration, seizure
- in
- Neurobiology of Disease
- volume
- 20
- issue
- 2
- pages
- 241 - 253
- publisher
- Elsevier
- external identifiers
-
- wos:000233096700008
- pmid:16242633
- scopus:23244448732
- ISSN
- 0969-9961
- DOI
- 10.1016/j.nbd.2005.03.006
- language
- English
- LU publication?
- yes
- id
- f01e79f7-f2fa-4ba5-81f4-5089b123cc3b (old id 213780)
- date added to LUP
- 2016-04-01 11:54:54
- date last changed
- 2023-01-03 01:15:59
@article{f01e79f7-f2fa-4ba5-81f4-5089b123cc3b,
abstract = {{Brain damaging insults cause alterations in neuronal networks that trigger epileptogenesis, and eventually lead to the appearance of spontaneous seizures. The present experiments were designed to study the cellular expression and functions of a cysteine proteinase inhibitor, cystatin C, whose gene expression is previously shown to be upregulated in the rat hippocampus during status epilepticus (SE)induced epileptogenesis. The present data showed that the expression of cystatin C protein increased in the mouse hippocampus 7 days following SE and localized mainly to astrocytes and microglia. Acute neuronal death in the hippocampus at 24 h after SE was reduced in cystatin C-/- mice. Also, the basal level of neurogenesis in the subgranular layer of dentate gyros was decreased in cystatin C-/- mice compared to wildtype littermates. Interestingly, migration of newly born neurons within the granule cell layer was attenuated in cystatin C-/- mice. These data demonstrate that cystatin C has a role in neuronal death and neurogenesis during SE-induced network reorganization.}},
author = {{Pirttila, T J and Lukasiuk, K and Håkansson, Katarina and Grubb, Anders and Abrahamson, Magnus and Pitkanen, A}},
issn = {{0969-9961}},
keywords = {{neural stem cells; mice; knock-out; kainic acid; hippocampus; FGF-2; epileptogenesis; epilepsy; neurodegeneration; seizure}},
language = {{eng}},
number = {{2}},
pages = {{241--253}},
publisher = {{Elsevier}},
series = {{Neurobiology of Disease}},
title = {{Cystatin C modulates neurodegeneration and neurogenesis following status epilepticus in mouse}},
url = {{http://dx.doi.org/10.1016/j.nbd.2005.03.006}},
doi = {{10.1016/j.nbd.2005.03.006}},
volume = {{20}},
year = {{2005}},
}