Genetic mechanisms underlying arrhythmogenic mitral valve prolapse : Current and future perspectives
(2023) In Heart Rhythm O2 4(9). p.581-591- Abstract
Mitral valve prolapse (MVP) is a heart valve disease that is often familial, affecting 2%–3% of the general population. MVP with or without mitral regurgitation can be associated with an increased risk of ventricular arrhythmias and sudden cardiac death (SCD). Research on familial MVP has specifically focused on genetic factors, which may explain the heritable component of the disease estimated to be present in 20%–35%. Furthermore, the structural and electrophysiological substrates underlying SCD/ventricular arrhythmia risk in MVP have been studied postmortem and in the electrophysiology laboratory, respectively. Understanding how familial MVP and rhythm disorders are related may help patients with MVP by individualizing risk and... (More)
Mitral valve prolapse (MVP) is a heart valve disease that is often familial, affecting 2%–3% of the general population. MVP with or without mitral regurgitation can be associated with an increased risk of ventricular arrhythmias and sudden cardiac death (SCD). Research on familial MVP has specifically focused on genetic factors, which may explain the heritable component of the disease estimated to be present in 20%–35%. Furthermore, the structural and electrophysiological substrates underlying SCD/ventricular arrhythmia risk in MVP have been studied postmortem and in the electrophysiology laboratory, respectively. Understanding how familial MVP and rhythm disorders are related may help patients with MVP by individualizing risk and working to develop effective management strategies. This contemporary, state-of-the-art, expert review focuses on genetic factors and familial components that underlie MVP and arrhythmia and encapsulates clinical, genetic, and electrophysiological issues that should be the objectives of future research.
(Less)
- author
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cardiac arrhythmia, Genetics, Mitral annular dysjunction, Mitral valve prolapse, Sudden cardiac death
- in
- Heart Rhythm O2
- volume
- 4
- issue
- 9
- pages
- 11 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:37744942
- scopus:85169793759
- ISSN
- 2666-5018
- DOI
- 10.1016/j.hroo.2023.08.003
- language
- English
- LU publication?
- yes
- id
- f02ed440-1f96-4dcb-9bf2-4aab5794a08f
- date added to LUP
- 2023-11-10 13:46:02
- date last changed
- 2024-04-22 05:09:15
@article{f02ed440-1f96-4dcb-9bf2-4aab5794a08f, abstract = {{<p>Mitral valve prolapse (MVP) is a heart valve disease that is often familial, affecting 2%–3% of the general population. MVP with or without mitral regurgitation can be associated with an increased risk of ventricular arrhythmias and sudden cardiac death (SCD). Research on familial MVP has specifically focused on genetic factors, which may explain the heritable component of the disease estimated to be present in 20%–35%. Furthermore, the structural and electrophysiological substrates underlying SCD/ventricular arrhythmia risk in MVP have been studied postmortem and in the electrophysiology laboratory, respectively. Understanding how familial MVP and rhythm disorders are related may help patients with MVP by individualizing risk and working to develop effective management strategies. This contemporary, state-of-the-art, expert review focuses on genetic factors and familial components that underlie MVP and arrhythmia and encapsulates clinical, genetic, and electrophysiological issues that should be the objectives of future research.</p>}}, author = {{Levy, Sydney and Sharaf Dabbagh, Ghaith and Giudicessi, John R. and Haqqani, Haris and Khanji, Mohammed Y. and Obeng-Gyimah, Edmond and Betts, Megan N. and Ricci, Fabrizio and Asatryan, Babken and Bouatia-Naji, Nabila and Nazarian, Saman and Chahal, C. Anwar A.}}, issn = {{2666-5018}}, keywords = {{Cardiac arrhythmia; Genetics; Mitral annular dysjunction; Mitral valve prolapse; Sudden cardiac death}}, language = {{eng}}, number = {{9}}, pages = {{581--591}}, publisher = {{Elsevier}}, series = {{Heart Rhythm O2}}, title = {{Genetic mechanisms underlying arrhythmogenic mitral valve prolapse : Current and future perspectives}}, url = {{http://dx.doi.org/10.1016/j.hroo.2023.08.003}}, doi = {{10.1016/j.hroo.2023.08.003}}, volume = {{4}}, year = {{2023}}, }