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Genetic mechanisms underlying arrhythmogenic mitral valve prolapse : Current and future perspectives

Levy, Sydney ; Sharaf Dabbagh, Ghaith ; Giudicessi, John R. ; Haqqani, Haris ; Khanji, Mohammed Y. ; Obeng-Gyimah, Edmond ; Betts, Megan N. ; Ricci, Fabrizio LU ; Asatryan, Babken and Bouatia-Naji, Nabila , et al. (2023) In Heart Rhythm O2 4(9). p.581-591
Abstract

Mitral valve prolapse (MVP) is a heart valve disease that is often familial, affecting 2%–3% of the general population. MVP with or without mitral regurgitation can be associated with an increased risk of ventricular arrhythmias and sudden cardiac death (SCD). Research on familial MVP has specifically focused on genetic factors, which may explain the heritable component of the disease estimated to be present in 20%–35%. Furthermore, the structural and electrophysiological substrates underlying SCD/ventricular arrhythmia risk in MVP have been studied postmortem and in the electrophysiology laboratory, respectively. Understanding how familial MVP and rhythm disorders are related may help patients with MVP by individualizing risk and... (More)

Mitral valve prolapse (MVP) is a heart valve disease that is often familial, affecting 2%–3% of the general population. MVP with or without mitral regurgitation can be associated with an increased risk of ventricular arrhythmias and sudden cardiac death (SCD). Research on familial MVP has specifically focused on genetic factors, which may explain the heritable component of the disease estimated to be present in 20%–35%. Furthermore, the structural and electrophysiological substrates underlying SCD/ventricular arrhythmia risk in MVP have been studied postmortem and in the electrophysiology laboratory, respectively. Understanding how familial MVP and rhythm disorders are related may help patients with MVP by individualizing risk and working to develop effective management strategies. This contemporary, state-of-the-art, expert review focuses on genetic factors and familial components that underlie MVP and arrhythmia and encapsulates clinical, genetic, and electrophysiological issues that should be the objectives of future research.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cardiac arrhythmia, Genetics, Mitral annular dysjunction, Mitral valve prolapse, Sudden cardiac death
in
Heart Rhythm O2
volume
4
issue
9
pages
11 pages
publisher
Elsevier
external identifiers
  • pmid:37744942
  • scopus:85169793759
ISSN
2666-5018
DOI
10.1016/j.hroo.2023.08.003
language
English
LU publication?
yes
id
f02ed440-1f96-4dcb-9bf2-4aab5794a08f
date added to LUP
2023-11-10 13:46:02
date last changed
2024-04-22 05:09:15
@article{f02ed440-1f96-4dcb-9bf2-4aab5794a08f,
  abstract     = {{<p>Mitral valve prolapse (MVP) is a heart valve disease that is often familial, affecting 2%–3% of the general population. MVP with or without mitral regurgitation can be associated with an increased risk of ventricular arrhythmias and sudden cardiac death (SCD). Research on familial MVP has specifically focused on genetic factors, which may explain the heritable component of the disease estimated to be present in 20%–35%. Furthermore, the structural and electrophysiological substrates underlying SCD/ventricular arrhythmia risk in MVP have been studied postmortem and in the electrophysiology laboratory, respectively. Understanding how familial MVP and rhythm disorders are related may help patients with MVP by individualizing risk and working to develop effective management strategies. This contemporary, state-of-the-art, expert review focuses on genetic factors and familial components that underlie MVP and arrhythmia and encapsulates clinical, genetic, and electrophysiological issues that should be the objectives of future research.</p>}},
  author       = {{Levy, Sydney and Sharaf Dabbagh, Ghaith and Giudicessi, John R. and Haqqani, Haris and Khanji, Mohammed Y. and Obeng-Gyimah, Edmond and Betts, Megan N. and Ricci, Fabrizio and Asatryan, Babken and Bouatia-Naji, Nabila and Nazarian, Saman and Chahal, C. Anwar A.}},
  issn         = {{2666-5018}},
  keywords     = {{Cardiac arrhythmia; Genetics; Mitral annular dysjunction; Mitral valve prolapse; Sudden cardiac death}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{581--591}},
  publisher    = {{Elsevier}},
  series       = {{Heart Rhythm O2}},
  title        = {{Genetic mechanisms underlying arrhythmogenic mitral valve prolapse : Current and future perspectives}},
  url          = {{http://dx.doi.org/10.1016/j.hroo.2023.08.003}},
  doi          = {{10.1016/j.hroo.2023.08.003}},
  volume       = {{4}},
  year         = {{2023}},
}