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The use of polyhydroxylated carboxylic acids and lactones to diminish biofilm formation of the pathogenic yeast : Candida albicans

Ishchuk, Olena P. LU ; Sterner, Olov LU ; Strevens, Helena LU ; Ellervik, Ulf LU and Manner, Sophie LU (2019) In RSC Advances 9(19). p.10983-10989
Abstract

The vaginal microbiome of healthy women is a diverse and dynamic system of various microorganisms. Any sudden change in microbe composition can increase the vaginal pH and thus lead to vaginal infections, conditions that affect a large percentage of women each year. The most common fungal strains involved in infections belong to the yeast species Candida albicans. The main virulence factor of C. albicans is the ability to transform from planktonic yeast-form cells into a filamentous form (hyphae or pseudohyphae), with the subsequent formation of biofilm. The hyphal form, constituted by filamentous cells, has the ability to invade tissue and induce inflammation. Our hypothesis is that certain polyhydroxylated carboxylic acids, that may... (More)

The vaginal microbiome of healthy women is a diverse and dynamic system of various microorganisms. Any sudden change in microbe composition can increase the vaginal pH and thus lead to vaginal infections, conditions that affect a large percentage of women each year. The most common fungal strains involved in infections belong to the yeast species Candida albicans. The main virulence factor of C. albicans is the ability to transform from planktonic yeast-form cells into a filamentous form (hyphae or pseudohyphae), with the subsequent formation of biofilm. The hyphal form, constituted by filamentous cells, has the ability to invade tissue and induce inflammation. Our hypothesis is that certain polyhydroxylated carboxylic acids, that may serve as an alternative carbohydrate source and at the same time lower the pH, function as an indicator of a nutrient-rich environment for C. albicans, which favors planktonic cells over hyphae, and thus diminish the formation of biofilm. We have shown that the biofilm formation in C. albicans and other Candida species can be significantly reduced by the addition of glucono-δ-lactone (GDL).

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
RSC Advances
volume
9
issue
19
pages
7 pages
publisher
Royal Society of Chemistry
external identifiers
  • scopus:85064212139
ISSN
2046-2069
DOI
10.1039/c9ra01204d
language
English
LU publication?
yes
id
f07fc44b-b60d-45e5-809a-1618dfa90b9e
date added to LUP
2019-05-02 14:59:04
date last changed
2020-01-13 01:41:30
@article{f07fc44b-b60d-45e5-809a-1618dfa90b9e,
  abstract     = {<p>The vaginal microbiome of healthy women is a diverse and dynamic system of various microorganisms. Any sudden change in microbe composition can increase the vaginal pH and thus lead to vaginal infections, conditions that affect a large percentage of women each year. The most common fungal strains involved in infections belong to the yeast species Candida albicans. The main virulence factor of C. albicans is the ability to transform from planktonic yeast-form cells into a filamentous form (hyphae or pseudohyphae), with the subsequent formation of biofilm. The hyphal form, constituted by filamentous cells, has the ability to invade tissue and induce inflammation. Our hypothesis is that certain polyhydroxylated carboxylic acids, that may serve as an alternative carbohydrate source and at the same time lower the pH, function as an indicator of a nutrient-rich environment for C. albicans, which favors planktonic cells over hyphae, and thus diminish the formation of biofilm. We have shown that the biofilm formation in C. albicans and other Candida species can be significantly reduced by the addition of glucono-δ-lactone (GDL).</p>},
  author       = {Ishchuk, Olena P. and Sterner, Olov and Strevens, Helena and Ellervik, Ulf and Manner, Sophie},
  issn         = {2046-2069},
  language     = {eng},
  number       = {19},
  pages        = {10983--10989},
  publisher    = {Royal Society of Chemistry},
  series       = {RSC Advances},
  title        = {The use of polyhydroxylated carboxylic acids and lactones to diminish biofilm formation of the pathogenic yeast : Candida albicans},
  url          = {http://dx.doi.org/10.1039/c9ra01204d},
  doi          = {10.1039/c9ra01204d},
  volume       = {9},
  year         = {2019},
}