Pattern of tumour growth of the primary colon cancer predicts long-term outcome after resection of liver metastases
(2016) In Scandinavian Journal of Gastroenterology 51(10). p.1233-1238- Abstract
Objective: To identify significant predictive factors for overall survival (OS) and disease-free survival (DFS) after liver resection for colon cancer metastases, with special focus on features of the primary colon cancer, such as lymph node ratio (LNR), vascular invasion, and perineural invasion. Methods: Patients operated for colonic cancer liver metastases between 2006 and 2014 were included. Details on patient characteristics, the primary colon cancer operation and metastatic disease were collected. Multivariate analysis was performed to select predictive variables for OS and DFS. Results: Median OS and DFS were 67 and 20 months, respectively. 1-, 3- and 5-year OS were 97, 76, and 52%. 1-, 3- and 5-year DFS were 65, 42, and 37%.... (More)
Objective: To identify significant predictive factors for overall survival (OS) and disease-free survival (DFS) after liver resection for colon cancer metastases, with special focus on features of the primary colon cancer, such as lymph node ratio (LNR), vascular invasion, and perineural invasion. Methods: Patients operated for colonic cancer liver metastases between 2006 and 2014 were included. Details on patient characteristics, the primary colon cancer operation and metastatic disease were collected. Multivariate analysis was performed to select predictive variables for OS and DFS. Results: Median OS and DFS were 67 and 20 months, respectively. 1-, 3- and 5-year OS were 97, 76, and 52%. 1-, 3- and 5-year DFS were 65, 42, and 37%. Multivariate analysis showed LNR to be an independent predictive factor for DFS but not for OS. Other identified predictive factors were vascular and perineural invasion of the primary colon cancer, size of the largest metastasis and severe complications after liver surgery for OS, and perineural invasion, number of liver metastases and preoperative CEA-level for DFS. Traditional N-stage was also considered to be an independent predictive factor for DFS in a separate multivariate analysis. Conclusions: LNR and perineural invasion of the primary colon cancer can be used as a prognostic variable for DFS after a concomitant liver resection for colon cancer metastases. Vascular and perineural invasion of the primary colon cancer are predictive for OS.
(Less)
- author
- Spelt, Lidewij LU ; Sasor, Agata ; Ansari, Daniel LU and Andersson, Roland LU
- organization
- publishing date
- 2016-10-02
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Colonic neoplasms, disease-free survival, liver resection, lymph nodes, metastasis, survival analysis
- in
- Scandinavian Journal of Gastroenterology
- volume
- 51
- issue
- 10
- pages
- 1233 - 1238
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:27306604
- wos:000381376100015
- scopus:84976905643
- ISSN
- 0036-5521
- DOI
- 10.1080/00365521.2016.1190400
- language
- English
- LU publication?
- yes
- id
- f0ad2e68-ebeb-4acf-b369-3672b6f83d3c
- date added to LUP
- 2016-07-20 10:25:43
- date last changed
- 2024-05-04 06:52:00
@article{f0ad2e68-ebeb-4acf-b369-3672b6f83d3c, abstract = {{<p>Objective: To identify significant predictive factors for overall survival (OS) and disease-free survival (DFS) after liver resection for colon cancer metastases, with special focus on features of the primary colon cancer, such as lymph node ratio (LNR), vascular invasion, and perineural invasion. Methods: Patients operated for colonic cancer liver metastases between 2006 and 2014 were included. Details on patient characteristics, the primary colon cancer operation and metastatic disease were collected. Multivariate analysis was performed to select predictive variables for OS and DFS. Results: Median OS and DFS were 67 and 20 months, respectively. 1-, 3- and 5-year OS were 97, 76, and 52%. 1-, 3- and 5-year DFS were 65, 42, and 37%. Multivariate analysis showed LNR to be an independent predictive factor for DFS but not for OS. Other identified predictive factors were vascular and perineural invasion of the primary colon cancer, size of the largest metastasis and severe complications after liver surgery for OS, and perineural invasion, number of liver metastases and preoperative CEA-level for DFS. Traditional N-stage was also considered to be an independent predictive factor for DFS in a separate multivariate analysis. Conclusions: LNR and perineural invasion of the primary colon cancer can be used as a prognostic variable for DFS after a concomitant liver resection for colon cancer metastases. Vascular and perineural invasion of the primary colon cancer are predictive for OS.</p>}}, author = {{Spelt, Lidewij and Sasor, Agata and Ansari, Daniel and Andersson, Roland}}, issn = {{0036-5521}}, keywords = {{Colonic neoplasms; disease-free survival; liver resection; lymph nodes; metastasis; survival analysis}}, language = {{eng}}, month = {{10}}, number = {{10}}, pages = {{1233--1238}}, publisher = {{Taylor & Francis}}, series = {{Scandinavian Journal of Gastroenterology}}, title = {{Pattern of tumour growth of the primary colon cancer predicts long-term outcome after resection of liver metastases}}, url = {{http://dx.doi.org/10.1080/00365521.2016.1190400}}, doi = {{10.1080/00365521.2016.1190400}}, volume = {{51}}, year = {{2016}}, }