Plasma Proneurotensin and Prediction of Cause-Specific Mortality in a Middle-aged Cohort During Long-term Follow-up
(2022) In The Journal of clinical endocrinology and metabolism 107(3). p.1204-1211- Abstract
CONTEXT: Neurotensin is associated with cardiometabolic diseases but its role with mortality risk in humans is unknown.
OBJECTIVE: This work aims to examine the prediction of proneurotensin (Pro-NT) with respect to total and cause-specific mortality in a middle-aged cohort.
METHODS: In the population-based middle-aged cohort (n = 4632; mean age, 57 years) of the Malmö Diet and Cancer Study, Pro-NT was assessed and total as well as cause-specific mortality was studied. Main cause of death was based on the International Classification of Diseases.
RESULTS: During a mean follow-up of 20 ± 3 years, 950 men and 956 women died. There was significantly increased mortality risk in individuals belonging to the highest quartile... (More)
CONTEXT: Neurotensin is associated with cardiometabolic diseases but its role with mortality risk in humans is unknown.
OBJECTIVE: This work aims to examine the prediction of proneurotensin (Pro-NT) with respect to total and cause-specific mortality in a middle-aged cohort.
METHODS: In the population-based middle-aged cohort (n = 4632; mean age, 57 years) of the Malmö Diet and Cancer Study, Pro-NT was assessed and total as well as cause-specific mortality was studied. Main cause of death was based on the International Classification of Diseases.
RESULTS: During a mean follow-up of 20 ± 3 years, 950 men and 956 women died. There was significantly increased mortality risk in individuals belonging to the highest quartile (Q) of Pro-NT (Q4, Pro-NT ≥ 149 pmol/L) compared with Qs 1 to 3 (Pro-NT < 149 pmol/L), hazard ratio (HR), 95% CI of 1.29 (1.17-1.42; P < .001). Data were adjusted for sex and age. No significant interaction was observed between Pro-NT and sex on mortality risk. Individuals within Q4 vs Qs 1 to 3 had an HR of 1.41 (95% CI, 1.18-1.68; P < .001) for death due to cardiovascular disease (n = 595/4632); 2.53 (95% CI, 1.37-4.67; P = .003), due to digestive tract disease (n = 42/4632), 1.62 (95% CI, 1.04-2.52; P = .032) due to mental and behavioral disease (n = 90/4632); and 1.91 (95% CI, 1.15-3.19; P = .013) due to unspecific causes (n = 64/4632). There was no significant relationship between Pro-NT and deaths due to cancer, infections, neurological, or other causes. Adjustment for cardiovascular risk factors only marginally changed these results.
CONCLUSION: The relationship between Pro-NT and total mortality risk was mainly driven by cardiovascular mortality, but high Pro-NT also predicts death from digestive, mental, and behavioral disease and deaths attributed to unspecific causes.
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- author
- Fawad, Ayesha LU ; Bergmann, Andreas ; Schulte, Janin ; Butt, Zahra A ; Nilsson, Peter M LU ; Bennet, Louise LU ; Orho-Melander, Marju LU and Melander, Olle LU
- organization
-
- Cardiovascular Research - Hypertension (research group)
- Internal Medicine - Epidemiology (research group)
- EpiHealth: Epidemiology for Health
- EXODIAB: Excellence of Diabetes Research in Sweden
- Family Medicine and Community Medicine (research group)
- Diabetes - Cardiovascular Disease (research group)
- MultiPark: Multidisciplinary research focused on Parkinson´s disease
- publishing date
- 2022-02-17
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Aged, Aged, 80 and over, Cause of Death, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neurotensin/blood, Prospective Studies, Protein Precursors/blood, Risk Assessment/methods
- in
- The Journal of clinical endocrinology and metabolism
- volume
- 107
- issue
- 3
- pages
- 1204 - 1211
- publisher
- Oxford University Press
- external identifiers
-
- scopus:85124850874
- pmid:34665860
- ISSN
- 1945-7197
- DOI
- 10.1210/clinem/dgab755
- language
- English
- LU publication?
- yes
- id
- f0b8bc2e-d0e7-492b-a194-0e8257656a26
- date added to LUP
- 2022-03-09 18:08:56
- date last changed
- 2024-08-30 05:18:56
@article{f0b8bc2e-d0e7-492b-a194-0e8257656a26, abstract = {{<p>CONTEXT: Neurotensin is associated with cardiometabolic diseases but its role with mortality risk in humans is unknown.</p><p>OBJECTIVE: This work aims to examine the prediction of proneurotensin (Pro-NT) with respect to total and cause-specific mortality in a middle-aged cohort.</p><p>METHODS: In the population-based middle-aged cohort (n = 4632; mean age, 57 years) of the Malmö Diet and Cancer Study, Pro-NT was assessed and total as well as cause-specific mortality was studied. Main cause of death was based on the International Classification of Diseases.</p><p>RESULTS: During a mean follow-up of 20 ± 3 years, 950 men and 956 women died. There was significantly increased mortality risk in individuals belonging to the highest quartile (Q) of Pro-NT (Q4, Pro-NT ≥ 149 pmol/L) compared with Qs 1 to 3 (Pro-NT < 149 pmol/L), hazard ratio (HR), 95% CI of 1.29 (1.17-1.42; P < .001). Data were adjusted for sex and age. No significant interaction was observed between Pro-NT and sex on mortality risk. Individuals within Q4 vs Qs 1 to 3 had an HR of 1.41 (95% CI, 1.18-1.68; P < .001) for death due to cardiovascular disease (n = 595/4632); 2.53 (95% CI, 1.37-4.67; P = .003), due to digestive tract disease (n = 42/4632), 1.62 (95% CI, 1.04-2.52; P = .032) due to mental and behavioral disease (n = 90/4632); and 1.91 (95% CI, 1.15-3.19; P = .013) due to unspecific causes (n = 64/4632). There was no significant relationship between Pro-NT and deaths due to cancer, infections, neurological, or other causes. Adjustment for cardiovascular risk factors only marginally changed these results.</p><p>CONCLUSION: The relationship between Pro-NT and total mortality risk was mainly driven by cardiovascular mortality, but high Pro-NT also predicts death from digestive, mental, and behavioral disease and deaths attributed to unspecific causes.</p>}}, author = {{Fawad, Ayesha and Bergmann, Andreas and Schulte, Janin and Butt, Zahra A and Nilsson, Peter M and Bennet, Louise and Orho-Melander, Marju and Melander, Olle}}, issn = {{1945-7197}}, keywords = {{Aged; Aged, 80 and over; Cause of Death; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neurotensin/blood; Prospective Studies; Protein Precursors/blood; Risk Assessment/methods}}, language = {{eng}}, month = {{02}}, number = {{3}}, pages = {{1204--1211}}, publisher = {{Oxford University Press}}, series = {{The Journal of clinical endocrinology and metabolism}}, title = {{Plasma Proneurotensin and Prediction of Cause-Specific Mortality in a Middle-aged Cohort During Long-term Follow-up}}, url = {{http://dx.doi.org/10.1210/clinem/dgab755}}, doi = {{10.1210/clinem/dgab755}}, volume = {{107}}, year = {{2022}}, }