Full-length HERV-H elements with env SU open reading frames in the human genome
(2002) In AIDS Research and Human Retroviruses 18(9). p.671-676- Abstract
- Human endogenous retroviruses (HERVs) are estimated to represent at least 1% of the human genome. An HERV-H env SU sequence (HERV-H19) was used to screen the high-throughput (htgs) and nonredundant (nr) databases for other HERV-H SU open reading frames (ORFs) and thus possible functional proteins. Using PCR with primers derived from HERV-H19 SU, we also obtained several new sequences with ORFs from a human DNA sample. In a phylogenetic analysis, ORF-containing sequences clustered with HERV-H sequences from chromosomes 1 and 2. SU ORF- and non-SU ORF-containing elements had about the same difference between 5' and 3' long terminal repeats (LTRs) (about 4%), indicating a similar time of integration. SU ORF sequences had a moderately high... (More)
- Human endogenous retroviruses (HERVs) are estimated to represent at least 1% of the human genome. An HERV-H env SU sequence (HERV-H19) was used to screen the high-throughput (htgs) and nonredundant (nr) databases for other HERV-H SU open reading frames (ORFs) and thus possible functional proteins. Using PCR with primers derived from HERV-H19 SU, we also obtained several new sequences with ORFs from a human DNA sample. In a phylogenetic analysis, ORF-containing sequences clustered with HERV-H sequences from chromosomes 1 and 2. SU ORF- and non-SU ORF-containing elements had about the same difference between 5' and 3' long terminal repeats (LTRs) (about 4%), indicating a similar time of integration. SU ORF sequences had a moderately high number of synonymous-versus-nonsynonymous mutations, which indicates a selection for maintenance of the HERV-H SU ORFs. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/335622
- author
- Jern, Patric ; Lindeskog, Mats LU ; Karlsson, Damita and Blomberg, Jonas
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- AIDS Research and Human Retroviruses
- volume
- 18
- issue
- 9
- pages
- 671 - 676
- publisher
- Mary Ann Liebert, Inc.
- external identifiers
-
- pmid:12079564
- wos:000176104600009
- scopus:0036434126
- ISSN
- 1931-8405
- DOI
- 10.1089/088922202760019383
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Virology (013017520)
- id
- f0c36658-1d89-437b-b7ea-78c0fb6625c1 (old id 335622)
- date added to LUP
- 2016-04-01 11:38:16
- date last changed
- 2022-01-26 07:59:56
@article{f0c36658-1d89-437b-b7ea-78c0fb6625c1, abstract = {{Human endogenous retroviruses (HERVs) are estimated to represent at least 1% of the human genome. An HERV-H env SU sequence (HERV-H19) was used to screen the high-throughput (htgs) and nonredundant (nr) databases for other HERV-H SU open reading frames (ORFs) and thus possible functional proteins. Using PCR with primers derived from HERV-H19 SU, we also obtained several new sequences with ORFs from a human DNA sample. In a phylogenetic analysis, ORF-containing sequences clustered with HERV-H sequences from chromosomes 1 and 2. SU ORF- and non-SU ORF-containing elements had about the same difference between 5' and 3' long terminal repeats (LTRs) (about 4%), indicating a similar time of integration. SU ORF sequences had a moderately high number of synonymous-versus-nonsynonymous mutations, which indicates a selection for maintenance of the HERV-H SU ORFs.}}, author = {{Jern, Patric and Lindeskog, Mats and Karlsson, Damita and Blomberg, Jonas}}, issn = {{1931-8405}}, language = {{eng}}, number = {{9}}, pages = {{671--676}}, publisher = {{Mary Ann Liebert, Inc.}}, series = {{AIDS Research and Human Retroviruses}}, title = {{Full-length HERV-H elements with env SU open reading frames in the human genome}}, url = {{http://dx.doi.org/10.1089/088922202760019383}}, doi = {{10.1089/088922202760019383}}, volume = {{18}}, year = {{2002}}, }