Injury-induced activation of ERK 1/2 in the sciatic nerve of healthy and diabetic rats.
(2011) In NeuroReport 22. p.73-77- Abstract
- Phosphorylation of extracellular-signal-regulated kinase 1/2 (p-ERK 1/2) was investigated by immunohistochemistry at 30 min, 1 h, and 48 h after nerve transection in the sciatic nerve of healthy and diabetic [streptozotocin (STZ)-induced diabetes mellitus and BioBreeding (BB; i.e. DR.lyp/lyp or BBDP)] rats. Transection injury increased the intensity of p-ERK 1/2 in nerve stumps at all time points. Staining was confined to Schwann cells with occasional faint staining in single axons. In diabetic rats, a lower intensity of p-ERK 1/2 was found at 1 and 48 h in the distal and proximal nerve stumps compared with healthy rats. STZ-induced diabetic rats were not different from BB rats. p-ERK 1/2 is activated differentially in Schwann cells after... (More)
- Phosphorylation of extracellular-signal-regulated kinase 1/2 (p-ERK 1/2) was investigated by immunohistochemistry at 30 min, 1 h, and 48 h after nerve transection in the sciatic nerve of healthy and diabetic [streptozotocin (STZ)-induced diabetes mellitus and BioBreeding (BB; i.e. DR.lyp/lyp or BBDP)] rats. Transection injury increased the intensity of p-ERK 1/2 in nerve stumps at all time points. Staining was confined to Schwann cells with occasional faint staining in single axons. In diabetic rats, a lower intensity of p-ERK 1/2 was found at 1 and 48 h in the distal and proximal nerve stumps compared with healthy rats. STZ-induced diabetic rats were not different from BB rats. p-ERK 1/2 is activated differentially in Schwann cells after nerve injury in diabetic rats, whereas activation in STZ-induced diabetic rats did not differ from BB rats. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1756493
- author
- Stenberg, Lena LU ; Kanje, Martin ; Mårtensson, Lisa and Dahlin, Lars LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- NeuroReport
- volume
- 22
- pages
- 73 - 77
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000285708300005
- pmid:21150475
- scopus:79551527646
- ISSN
- 1473-558X
- DOI
- 10.1097/WNR.0b013e328342986c
- project
- Nerve regeneration - signal transduktion mechanisms, timing and alternatives to nerve grafts
- language
- English
- LU publication?
- yes
- id
- f0c9ff83-2379-4a2b-ae15-09d6682ddc0b (old id 1756493)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21150475?dopt=Abstract
- date added to LUP
- 2016-04-04 07:00:35
- date last changed
- 2022-01-29 01:33:28
@article{f0c9ff83-2379-4a2b-ae15-09d6682ddc0b, abstract = {{Phosphorylation of extracellular-signal-regulated kinase 1/2 (p-ERK 1/2) was investigated by immunohistochemistry at 30 min, 1 h, and 48 h after nerve transection in the sciatic nerve of healthy and diabetic [streptozotocin (STZ)-induced diabetes mellitus and BioBreeding (BB; i.e. DR.lyp/lyp or BBDP)] rats. Transection injury increased the intensity of p-ERK 1/2 in nerve stumps at all time points. Staining was confined to Schwann cells with occasional faint staining in single axons. In diabetic rats, a lower intensity of p-ERK 1/2 was found at 1 and 48 h in the distal and proximal nerve stumps compared with healthy rats. STZ-induced diabetic rats were not different from BB rats. p-ERK 1/2 is activated differentially in Schwann cells after nerve injury in diabetic rats, whereas activation in STZ-induced diabetic rats did not differ from BB rats.}}, author = {{Stenberg, Lena and Kanje, Martin and Mårtensson, Lisa and Dahlin, Lars}}, issn = {{1473-558X}}, language = {{eng}}, pages = {{73--77}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{NeuroReport}}, title = {{Injury-induced activation of ERK 1/2 in the sciatic nerve of healthy and diabetic rats.}}, url = {{http://dx.doi.org/10.1097/WNR.0b013e328342986c}}, doi = {{10.1097/WNR.0b013e328342986c}}, volume = {{22}}, year = {{2011}}, }