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Infiltration of γδ T cells, IL-17 + T cells and FoxP3 + T cells in human breast cancer

Allaoui, Roni LU ; Hagerling, Catharina LU ; Desmond, Eva; Warfvinge, Carl Fredrik LU ; Jirström, Karin LU and Leandersson, Karin LU (2017) In Cancer Biomarkers 20(4). p.395-409
Abstract

BACKGROUND: Tumor-infiltrating lymphocytes (TILs) have a strong prognostic value in various forms of cancers. These data often refer to use of the pan-T cell marker CD3, or the cytotoxic T lymphocyte marker CD8α. However, T cells are a heterogeneous group of cells with a wide array of effector mechanisms ranging from immunosuppression to cytotoxicity. OBJECTIVE: In this study we have investigated the prognostic effects of some unconventional T cell subtypes in breast cancer; γδ T cells, IL-17+ T cells and FoxP3+ T cells (Tregs) in relation to the conventional CD3 and CD8α T cell markers. METHODS: This was done using immunohistochemistry on a human breast cancer tissue microarray consisting of 498 consecutive cases of primary breast... (More)

BACKGROUND: Tumor-infiltrating lymphocytes (TILs) have a strong prognostic value in various forms of cancers. These data often refer to use of the pan-T cell marker CD3, or the cytotoxic T lymphocyte marker CD8α. However, T cells are a heterogeneous group of cells with a wide array of effector mechanisms ranging from immunosuppression to cytotoxicity. OBJECTIVE: In this study we have investigated the prognostic effects of some unconventional T cell subtypes in breast cancer; γδ T cells, IL-17+ T cells and FoxP3+ T cells (Tregs) in relation to the conventional CD3 and CD8α T cell markers. METHODS: This was done using immunohistochemistry on a human breast cancer tissue microarray consisting of 498 consecutive cases of primary breast cancer. RESULTS: Infiltration of γδ T cells and T cell infiltration in general (CD3), correlated with a good prognosis, while Treg infiltration with a worse. Infiltration of γδ T cells was associated with a significantly improved clinical outcome in all breast cancer subtypes except triple negative tumors. Only infiltration of either CD3+ or CD8α+ cells was independently associated with better prognosis for all breast cancer patients. CONCLUSIONS: This study sheds further light on the prognostic impact of various T cell subtypes in breast cancer.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Breast cancer, prognosis, T lymphocytes, TILs, unconventional T cells
in
Cancer Biomarkers
volume
20
issue
4
pages
15 pages
publisher
IOS Press
external identifiers
  • scopus:85039164242
ISSN
1574-0153
DOI
10.3233/CBM-170026
language
English
LU publication?
yes
id
f0d850e9-69c3-49b1-85a2-288d9eebf374
date added to LUP
2018-01-22 18:08:38
date last changed
2018-01-23 03:00:04
@article{f0d850e9-69c3-49b1-85a2-288d9eebf374,
  abstract     = {<p>BACKGROUND: Tumor-infiltrating lymphocytes (TILs) have a strong prognostic value in various forms of cancers. These data often refer to use of the pan-T cell marker CD3, or the cytotoxic T lymphocyte marker CD8α. However, T cells are a heterogeneous group of cells with a wide array of effector mechanisms ranging from immunosuppression to cytotoxicity. OBJECTIVE: In this study we have investigated the prognostic effects of some unconventional T cell subtypes in breast cancer; γδ T cells, IL-17+ T cells and FoxP3+ T cells (Tregs) in relation to the conventional CD3 and CD8α T cell markers. METHODS: This was done using immunohistochemistry on a human breast cancer tissue microarray consisting of 498 consecutive cases of primary breast cancer. RESULTS: Infiltration of γδ T cells and T cell infiltration in general (CD3), correlated with a good prognosis, while Treg infiltration with a worse. Infiltration of γδ T cells was associated with a significantly improved clinical outcome in all breast cancer subtypes except triple negative tumors. Only infiltration of either CD3+ or CD8α+ cells was independently associated with better prognosis for all breast cancer patients. CONCLUSIONS: This study sheds further light on the prognostic impact of various T cell subtypes in breast cancer.</p>},
  author       = {Allaoui, Roni and Hagerling, Catharina and Desmond, Eva and Warfvinge, Carl Fredrik and Jirström, Karin and Leandersson, Karin},
  issn         = {1574-0153},
  keyword      = {Breast cancer,prognosis,T lymphocytes,TILs,unconventional T cells},
  language     = {eng},
  number       = {4},
  pages        = {395--409},
  publisher    = {IOS Press},
  series       = {Cancer Biomarkers},
  title        = {Infiltration of γδ T cells, IL-17 + T cells and FoxP3 + T cells in human breast cancer},
  url          = {http://dx.doi.org/10.3233/CBM-170026},
  volume       = {20},
  year         = {2017},
}