Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Patterns of Human Papillomavirus Types in Multiple Infections: An Analysis in Women and Men of the High Throughput Human Papillomavirus Monitoring Study

Vaccarella, Salvatore ; Söderlund Strand, Anna LU ; Franceschi, Silvia ; Plummer, Martyn and Dillner, Joakim LU (2013) In PLoS ONE 8(8).
Abstract
Background: To evaluate the pattern of co-infection of human papillomavirus (HPV) types in both sexes in Sweden. Methods: Cell samples from genital swabs, first-void urine, and genital swabs immersed in first-void urine were collected in the present cross-sectional High Throughput HPV Monitoring study. Overall, 31,717 samples from women and 9,949 from men (mean age 25) were tested for 16 HPV types using mass spectrometry. Multilevel logistic regression was used to estimate the expected number of multiple infections with specific HPV types, adjusted for age, type of sample, and accounting for correlations between HPV types due to unobserved risk factors using sample-level random effects. Bonferroni correction was used to allow for multiple... (More)
Background: To evaluate the pattern of co-infection of human papillomavirus (HPV) types in both sexes in Sweden. Methods: Cell samples from genital swabs, first-void urine, and genital swabs immersed in first-void urine were collected in the present cross-sectional High Throughput HPV Monitoring study. Overall, 31,717 samples from women and 9,949 from men (mean age 25) were tested for 16 HPV types using mass spectrometry. Multilevel logistic regression was used to estimate the expected number of multiple infections with specific HPV types, adjusted for age, type of sample, and accounting for correlations between HPV types due to unobserved risk factors using sample-level random effects. Bonferroni correction was used to allow for multiple comparisons (120). Results: Observed-to-expected ratio for any multiple infections was slightly above unity in both sexes, but, for most 2-type combinations, there was no evidence of significant departure from expected numbers. HPV6/18 was found more often and HPV51/68 and 6/68 less often than expected. However, HPV68 tended to be generally underrepresented in co-infections, suggesting a sub-optimal performance of our testing method for this HPV type. Conclusions: We found no evidence for positive or negative clustering between HPV types included in the current prophylactic vaccines and other untargeted oncogenic types, in either sex. (Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
8
issue
8
article number
e71617
publisher
Public Library of Science (PLoS)
external identifiers
  • wos:000323425700074
  • pmid:23977090
  • scopus:84876514633
ISSN
1932-6203
DOI
10.1371/journal.pone.0071617
language
English
LU publication?
yes
id
f0d90cfe-5016-4163-99bb-5dd953e90f73 (old id 4063434)
date added to LUP
2016-04-01 14:04:18
date last changed
2022-05-15 08:37:14
@article{f0d90cfe-5016-4163-99bb-5dd953e90f73,
  abstract     = {{Background: To evaluate the pattern of co-infection of human papillomavirus (HPV) types in both sexes in Sweden. Methods: Cell samples from genital swabs, first-void urine, and genital swabs immersed in first-void urine were collected in the present cross-sectional High Throughput HPV Monitoring study. Overall, 31,717 samples from women and 9,949 from men (mean age 25) were tested for 16 HPV types using mass spectrometry. Multilevel logistic regression was used to estimate the expected number of multiple infections with specific HPV types, adjusted for age, type of sample, and accounting for correlations between HPV types due to unobserved risk factors using sample-level random effects. Bonferroni correction was used to allow for multiple comparisons (120). Results: Observed-to-expected ratio for any multiple infections was slightly above unity in both sexes, but, for most 2-type combinations, there was no evidence of significant departure from expected numbers. HPV6/18 was found more often and HPV51/68 and 6/68 less often than expected. However, HPV68 tended to be generally underrepresented in co-infections, suggesting a sub-optimal performance of our testing method for this HPV type. Conclusions: We found no evidence for positive or negative clustering between HPV types included in the current prophylactic vaccines and other untargeted oncogenic types, in either sex.}},
  author       = {{Vaccarella, Salvatore and Söderlund Strand, Anna and Franceschi, Silvia and Plummer, Martyn and Dillner, Joakim}},
  issn         = {{1932-6203}},
  language     = {{eng}},
  number       = {{8}},
  publisher    = {{Public Library of Science (PLoS)}},
  series       = {{PLoS ONE}},
  title        = {{Patterns of Human Papillomavirus Types in Multiple Infections: An Analysis in Women and Men of the High Throughput Human Papillomavirus Monitoring Study}},
  url          = {{https://lup.lub.lu.se/search/files/3762300/4864849.pdf}},
  doi          = {{10.1371/journal.pone.0071617}},
  volume       = {{8}},
  year         = {{2013}},
}