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Increased IL-17RA and IL-17RC in End-Stage COPD and the Contribution to Mast Cell Secretion of FGF-2 and VEGF

Roos, Abraham B. LU ; Mori, Michiko LU ; Gura, Harpreet K.; Lorentz, Axel; Bjermer, Leif LU ; Hoffmann, Hans-Jürgen; Erjefält, Jonas S. LU and Stampfli, Martin R (2017) In Respiratory Research 18(1).
Abstract

Mast cells are accumulated in advanced chronic obstructive pulmonary disease (COPD), and interleukin (IL)-17 signaling plays a role in disease progression. The expression, localization and functional relevance of IL-17 receptor (R)A and IL-17RC was explored in COPD by immunodetection, and functional assays. IL-17RA and IL-17RC was increased in very severe COPD, and expressed by mast cells. Increased secretion of the pro-angiogenic basic fibroblast growth factor and vascular endothelial growth factor was observed in vitro-maintained mast cells stimulated with IL-17A. Expression of these mediators was confirmed in end-stage COPD. Thus, accumulation of mast cells in COPD may contribute to vascular remodeling.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Respiratory Research
volume
18
issue
1
publisher
BioMed Central
external identifiers
  • scopus:85015146327
ISSN
1465-9921
DOI
10.1186/s12931-017-0534-9
language
English
LU publication?
yes
id
f13963ff-47ee-4feb-b3f2-45e314c414f3
date added to LUP
2017-04-03 10:37:50
date last changed
2017-04-04 03:00:02
@article{f13963ff-47ee-4feb-b3f2-45e314c414f3,
  abstract     = {<p>Mast cells are accumulated in advanced chronic obstructive pulmonary disease (COPD), and interleukin (IL)-17 signaling plays a role in disease progression. The expression, localization and functional relevance of IL-17 receptor (R)A and IL-17RC was explored in COPD by immunodetection, and functional assays. IL-17RA and IL-17RC was increased in very severe COPD, and expressed by mast cells. Increased secretion of the pro-angiogenic basic fibroblast growth factor and vascular endothelial growth factor was observed in vitro-maintained mast cells stimulated with IL-17A. Expression of these mediators was confirmed in end-stage COPD. Thus, accumulation of mast cells in COPD may contribute to vascular remodeling.</p>},
  articleno    = {48},
  author       = {Roos, Abraham B. and Mori, Michiko and Gura, Harpreet K. and Lorentz, Axel and Bjermer, Leif and Hoffmann, Hans-Jürgen and Erjefält, Jonas S. and Stampfli, Martin R},
  issn         = {1465-9921},
  language     = {eng},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {Respiratory Research},
  title        = {Increased IL-17RA and IL-17RC in End-Stage COPD and the Contribution to Mast Cell Secretion of FGF-2 and VEGF},
  url          = {http://dx.doi.org/10.1186/s12931-017-0534-9},
  volume       = {18},
  year         = {2017},
}