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Increased IL-17RA and IL-17RC in End-Stage COPD and the Contribution to Mast Cell Secretion of FGF-2 and VEGF

Roos, Abraham B. LU ; Mori, Michiko LU ; Gura, Harpreet K. ; Lorentz, Axel ; Bjermer, Leif LU ; Hoffmann, Hans-Jürgen ; Erjefält, Jonas S. LU and Stampfli, Martin R (2017) In Respiratory Research 18(1).
Abstract

Mast cells are accumulated in advanced chronic obstructive pulmonary disease (COPD), and interleukin (IL)-17 signaling plays a role in disease progression. The expression, localization and functional relevance of IL-17 receptor (R)A and IL-17RC was explored in COPD by immunodetection, and functional assays. IL-17RA and IL-17RC was increased in very severe COPD, and expressed by mast cells. Increased secretion of the pro-angiogenic basic fibroblast growth factor and vascular endothelial growth factor was observed in vitro-maintained mast cells stimulated with IL-17A. Expression of these mediators was confirmed in end-stage COPD. Thus, accumulation of mast cells in COPD may contribute to vascular remodeling.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Respiratory Research
volume
18
issue
1
article number
48
publisher
BioMed Central (BMC)
external identifiers
  • scopus:85015146327
  • pmid:28298222
  • wos:000396919100001
ISSN
1465-9921
DOI
10.1186/s12931-017-0534-9
language
English
LU publication?
yes
id
f13963ff-47ee-4feb-b3f2-45e314c414f3
date added to LUP
2017-04-03 10:37:50
date last changed
2025-04-04 13:54:50
@article{f13963ff-47ee-4feb-b3f2-45e314c414f3,
  abstract     = {{<p>Mast cells are accumulated in advanced chronic obstructive pulmonary disease (COPD), and interleukin (IL)-17 signaling plays a role in disease progression. The expression, localization and functional relevance of IL-17 receptor (R)A and IL-17RC was explored in COPD by immunodetection, and functional assays. IL-17RA and IL-17RC was increased in very severe COPD, and expressed by mast cells. Increased secretion of the pro-angiogenic basic fibroblast growth factor and vascular endothelial growth factor was observed in vitro-maintained mast cells stimulated with IL-17A. Expression of these mediators was confirmed in end-stage COPD. Thus, accumulation of mast cells in COPD may contribute to vascular remodeling.</p>}},
  author       = {{Roos, Abraham B. and Mori, Michiko and Gura, Harpreet K. and Lorentz, Axel and Bjermer, Leif and Hoffmann, Hans-Jürgen and Erjefält, Jonas S. and Stampfli, Martin R}},
  issn         = {{1465-9921}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Respiratory Research}},
  title        = {{Increased IL-17RA and IL-17RC in End-Stage COPD and the Contribution to Mast Cell Secretion of FGF-2 and VEGF}},
  url          = {{http://dx.doi.org/10.1186/s12931-017-0534-9}},
  doi          = {{10.1186/s12931-017-0534-9}},
  volume       = {{18}},
  year         = {{2017}},
}