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The influence of water activity on the enantioselectivity in the enzyme- catalyzed reduction of 2-pentanone

Jönsson, Åsa LU ; Van Breukelen, Willem ; Wehtje, Ernst LU ; Adlercreutz, Patrick LU orcid and Mattiasson, Bo LU (1998) In Journal of Molecular Catalysis - B Enzymatic 5(1-4). p.273-276
Abstract

The stereoselective reduction of 2-pentanone by alcohol dehydrogenase from Thermoanaerobium brockii was studied at controlled water activity and at different reaction temperatures. The reaction rate increased when water activity was increased from 0.32 to 0.96 and when raising the temperature from 5°C to 40°C. The enantioselectivity, E, reached a plateau value at high water activities. The enantioselectivity increased with decreasing reaction temperature.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alcohol dehydrogenase, Enantioselectivity, Organic medium, Temperature, Thermoanaerobium brockii, Water activity
in
Journal of Molecular Catalysis - B Enzymatic
volume
5
issue
1-4
pages
4 pages
publisher
Elsevier
external identifiers
  • scopus:0032530211
ISSN
1381-1177
DOI
10.1016/S1381-1177(98)00048-4
language
English
LU publication?
yes
id
f13c96ac-3288-49a0-8525-04eaff1a0534
date added to LUP
2019-06-20 16:05:15
date last changed
2022-01-31 22:13:25
@article{f13c96ac-3288-49a0-8525-04eaff1a0534,
  abstract     = {{<p>The stereoselective reduction of 2-pentanone by alcohol dehydrogenase from Thermoanaerobium brockii was studied at controlled water activity and at different reaction temperatures. The reaction rate increased when water activity was increased from 0.32 to 0.96 and when raising the temperature from 5°C to 40°C. The enantioselectivity, E, reached a plateau value at high water activities. The enantioselectivity increased with decreasing reaction temperature.</p>}},
  author       = {{Jönsson, Åsa and Van Breukelen, Willem and Wehtje, Ernst and Adlercreutz, Patrick and Mattiasson, Bo}},
  issn         = {{1381-1177}},
  keywords     = {{Alcohol dehydrogenase; Enantioselectivity; Organic medium; Temperature; Thermoanaerobium brockii; Water activity}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{1-4}},
  pages        = {{273--276}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Molecular Catalysis - B Enzymatic}},
  title        = {{The influence of water activity on the enantioselectivity in the enzyme- catalyzed reduction of 2-pentanone}},
  url          = {{http://dx.doi.org/10.1016/S1381-1177(98)00048-4}},
  doi          = {{10.1016/S1381-1177(98)00048-4}},
  volume       = {{5}},
  year         = {{1998}},
}