The influence of water activity on the enantioselectivity in the enzyme- catalyzed reduction of 2-pentanone
(1998) In Journal of Molecular Catalysis - B Enzymatic 5(1-4). p.273-276- Abstract
The stereoselective reduction of 2-pentanone by alcohol dehydrogenase from Thermoanaerobium brockii was studied at controlled water activity and at different reaction temperatures. The reaction rate increased when water activity was increased from 0.32 to 0.96 and when raising the temperature from 5°C to 40°C. The enantioselectivity, E, reached a plateau value at high water activities. The enantioselectivity increased with decreasing reaction temperature.
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https://lup.lub.lu.se/record/f13c96ac-3288-49a0-8525-04eaff1a0534
- author
- Jönsson, Åsa LU ; Van Breukelen, Willem ; Wehtje, Ernst LU ; Adlercreutz, Patrick LU and Mattiasson, Bo LU
- organization
- publishing date
- 1998-09-15
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Alcohol dehydrogenase, Enantioselectivity, Organic medium, Temperature, Thermoanaerobium brockii, Water activity
- in
- Journal of Molecular Catalysis - B Enzymatic
- volume
- 5
- issue
- 1-4
- pages
- 4 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:0032530211
- ISSN
- 1381-1177
- DOI
- 10.1016/S1381-1177(98)00048-4
- language
- English
- LU publication?
- yes
- id
- f13c96ac-3288-49a0-8525-04eaff1a0534
- date added to LUP
- 2019-06-20 16:05:15
- date last changed
- 2022-01-31 22:13:25
@article{f13c96ac-3288-49a0-8525-04eaff1a0534, abstract = {{<p>The stereoselective reduction of 2-pentanone by alcohol dehydrogenase from Thermoanaerobium brockii was studied at controlled water activity and at different reaction temperatures. The reaction rate increased when water activity was increased from 0.32 to 0.96 and when raising the temperature from 5°C to 40°C. The enantioselectivity, E, reached a plateau value at high water activities. The enantioselectivity increased with decreasing reaction temperature.</p>}}, author = {{Jönsson, Åsa and Van Breukelen, Willem and Wehtje, Ernst and Adlercreutz, Patrick and Mattiasson, Bo}}, issn = {{1381-1177}}, keywords = {{Alcohol dehydrogenase; Enantioselectivity; Organic medium; Temperature; Thermoanaerobium brockii; Water activity}}, language = {{eng}}, month = {{09}}, number = {{1-4}}, pages = {{273--276}}, publisher = {{Elsevier}}, series = {{Journal of Molecular Catalysis - B Enzymatic}}, title = {{The influence of water activity on the enantioselectivity in the enzyme- catalyzed reduction of 2-pentanone}}, url = {{http://dx.doi.org/10.1016/S1381-1177(98)00048-4}}, doi = {{10.1016/S1381-1177(98)00048-4}}, volume = {{5}}, year = {{1998}}, }