A functional role of the cyclin-dependent kinase inhibitor 1 (p21(WAF1/CIP1)) for neuronal preconditioning
(2013) In Journal of Cerebral Blood Flow and Metabolism 33(3). p.351-355- Abstract
- Hypoxic preconditioning is thought to rely on gene products regulated by hypoxia-inducible factor (HIF)-1. Here, we show that the HIF-1 target gene cyclin-dependent kinase inhibitor 1, p21(WAF1/CIP1), is essential for neuroprotection by hypoxic/aglycemic or erythropoietin preconditioning using wild-type and p21(WAF1/CIP1)-deficient neurons. Furthermore, overexpression of wild-type p21(WAF1/CIP1) or phospho-mutants significantly increased cell death after hypoxia/aglycemia. Moreover, deferoxamine-induced endogenous tolerance did not involve p21(WAF1/CIP1) expression in cortical neurons. Our data suggest that balanced expression and potentially posttranslational regulation of p21(WAF1/CIP1) is required for hypoxic preconditioning. Journal of... (More)
- Hypoxic preconditioning is thought to rely on gene products regulated by hypoxia-inducible factor (HIF)-1. Here, we show that the HIF-1 target gene cyclin-dependent kinase inhibitor 1, p21(WAF1/CIP1), is essential for neuroprotection by hypoxic/aglycemic or erythropoietin preconditioning using wild-type and p21(WAF1/CIP1)-deficient neurons. Furthermore, overexpression of wild-type p21(WAF1/CIP1) or phospho-mutants significantly increased cell death after hypoxia/aglycemia. Moreover, deferoxamine-induced endogenous tolerance did not involve p21(WAF1/CIP1) expression in cortical neurons. Our data suggest that balanced expression and potentially posttranslational regulation of p21(WAF1/CIP1) is required for hypoxic preconditioning. Journal of Cerebral Blood Flow & Metabolism (2013) 33, 351-355; doi:10.1038/jcbfm.2012.213; published online 9 January 2013 (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3670067
- author
- Mergenthaler, Philipp ; Muselmann, Claudia ; Suenwoldt, Juliane ; Isaev, Nickolay K. ; Wieloch, Tadeusz LU ; Dirnagl, Ulrich ; Meisel, Andreas and Ruscher, Karsten LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cyclin-dependent kinase inhibitor 1 (p21(WAF1/CIP1)), erythropoietin, hypoxia, ischemia, HIF-1 target genes, preconditioning
- in
- Journal of Cerebral Blood Flow and Metabolism
- volume
- 33
- issue
- 3
- pages
- 351 - 355
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000315590200006
- scopus:84874645218
- pmid:23299246
- ISSN
- 1559-7016
- DOI
- 10.1038/jcbfm.2012.213
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Laboratory for Experimental Brain Research (013041000)
- id
- f1cfc3ce-8a1a-41b0-bfa4-5611ab5d5511 (old id 3670067)
- date added to LUP
- 2016-04-01 12:59:50
- date last changed
- 2022-02-26 18:44:26
@article{f1cfc3ce-8a1a-41b0-bfa4-5611ab5d5511, abstract = {{Hypoxic preconditioning is thought to rely on gene products regulated by hypoxia-inducible factor (HIF)-1. Here, we show that the HIF-1 target gene cyclin-dependent kinase inhibitor 1, p21(WAF1/CIP1), is essential for neuroprotection by hypoxic/aglycemic or erythropoietin preconditioning using wild-type and p21(WAF1/CIP1)-deficient neurons. Furthermore, overexpression of wild-type p21(WAF1/CIP1) or phospho-mutants significantly increased cell death after hypoxia/aglycemia. Moreover, deferoxamine-induced endogenous tolerance did not involve p21(WAF1/CIP1) expression in cortical neurons. Our data suggest that balanced expression and potentially posttranslational regulation of p21(WAF1/CIP1) is required for hypoxic preconditioning. Journal of Cerebral Blood Flow & Metabolism (2013) 33, 351-355; doi:10.1038/jcbfm.2012.213; published online 9 January 2013}}, author = {{Mergenthaler, Philipp and Muselmann, Claudia and Suenwoldt, Juliane and Isaev, Nickolay K. and Wieloch, Tadeusz and Dirnagl, Ulrich and Meisel, Andreas and Ruscher, Karsten}}, issn = {{1559-7016}}, keywords = {{cyclin-dependent kinase inhibitor 1 (p21(WAF1/CIP1)); erythropoietin; hypoxia; ischemia; HIF-1 target genes; preconditioning}}, language = {{eng}}, number = {{3}}, pages = {{351--355}}, publisher = {{Nature Publishing Group}}, series = {{Journal of Cerebral Blood Flow and Metabolism}}, title = {{A functional role of the cyclin-dependent kinase inhibitor 1 (p21(WAF1/CIP1)) for neuronal preconditioning}}, url = {{http://dx.doi.org/10.1038/jcbfm.2012.213}}, doi = {{10.1038/jcbfm.2012.213}}, volume = {{33}}, year = {{2013}}, }