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Cognitive and Neuroanatomic Accounts of Referential Communication in Focal Dementia

Healey, Meghan; Spotorno, Nicola LU ; Olm, Christopher; Irwin, David J. and Grossman, Murray (2019) In eNeuro 6(5).
Abstract

The primary function of language is to communicate-that is, to make individuals reach a state of mutual understanding about a particular thought or idea. Accordingly, daily communication is truly a task of social coordination. Indeed, successful interactions require individuals to (1) track and adopt a partner's perspective and (2) continuously shift between the numerous elements relevant to the exchange. Here, we use a referential communication task to study the contributions of perspective taking and executive function to effective communication in nonaphasic human patients with behavioral variant frontotemporal dementia (bvFTD). Similar to previous work, the task was to identify a target object, embedded among an array of... (More)

The primary function of language is to communicate-that is, to make individuals reach a state of mutual understanding about a particular thought or idea. Accordingly, daily communication is truly a task of social coordination. Indeed, successful interactions require individuals to (1) track and adopt a partner's perspective and (2) continuously shift between the numerous elements relevant to the exchange. Here, we use a referential communication task to study the contributions of perspective taking and executive function to effective communication in nonaphasic human patients with behavioral variant frontotemporal dementia (bvFTD). Similar to previous work, the task was to identify a target object, embedded among an array of competitors, for an interlocutor. Results indicate that bvFTD patients are impaired relative to control subjects in selecting the optimal, precise response. Neuropsychological testing related this performance to mental set shifting, but not to working memory or inhibition. Follow-up analyses indicated that some bvFTD patients perform equally well as control subjects, while a second, clinically matched patient group performs significantly worse. Importantly, the neuropsychological profiles of these subgroups differed only in set shifting. Finally, structural MRI analyses related patient impairment to gray matter disease in orbitofrontal, medial prefrontal, and dorsolateral prefrontal cortex, all regions previously implicated in social cognition and overlapping those related to set shifting. Complementary white matter analyses implicated uncinate fasciculus, which carries projections between orbitofrontal and temporal cortices. Together, these findings demonstrate that impaired referential communication in bvFTD is cognitively related to set shifting, and anatomically related to a social-executive network including prefrontal cortices and uncinate fasciculus.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
frontotemporal degeneration, language, perspective taking, prefrontal cortex, referential communication, social cognition
in
eNeuro
volume
6
issue
5
publisher
Society for Neuroscience
external identifiers
  • scopus:85072718049
ISSN
2373-2822
DOI
10.1523/ENEURO.0488-18.2019
language
English
LU publication?
yes
id
f1ea95b5-c150-40b0-80dd-93edebe7a358
date added to LUP
2019-10-10 12:00:44
date last changed
2019-10-10 12:00:44
@article{f1ea95b5-c150-40b0-80dd-93edebe7a358,
  abstract     = {<p>The primary function of language is to communicate-that is, to make individuals reach a state of mutual understanding about a particular thought or idea. Accordingly, daily communication is truly a task of social coordination. Indeed, successful interactions require individuals to (1) track and adopt a partner's perspective and (2) continuously shift between the numerous elements relevant to the exchange. Here, we use a referential communication task to study the contributions of perspective taking and executive function to effective communication in nonaphasic human patients with behavioral variant frontotemporal dementia (bvFTD). Similar to previous work, the task was to identify a target object, embedded among an array of competitors, for an interlocutor. Results indicate that bvFTD patients are impaired relative to control subjects in selecting the optimal, precise response. Neuropsychological testing related this performance to mental set shifting, but not to working memory or inhibition. Follow-up analyses indicated that some bvFTD patients perform equally well as control subjects, while a second, clinically matched patient group performs significantly worse. Importantly, the neuropsychological profiles of these subgroups differed only in set shifting. Finally, structural MRI analyses related patient impairment to gray matter disease in orbitofrontal, medial prefrontal, and dorsolateral prefrontal cortex, all regions previously implicated in social cognition and overlapping those related to set shifting. Complementary white matter analyses implicated uncinate fasciculus, which carries projections between orbitofrontal and temporal cortices. Together, these findings demonstrate that impaired referential communication in bvFTD is cognitively related to set shifting, and anatomically related to a social-executive network including prefrontal cortices and uncinate fasciculus.</p>},
  author       = {Healey, Meghan and Spotorno, Nicola and Olm, Christopher and Irwin, David J. and Grossman, Murray},
  issn         = {2373-2822},
  keyword      = {frontotemporal degeneration,language,perspective taking,prefrontal cortex,referential communication,social cognition},
  language     = {eng},
  number       = {5},
  publisher    = {Society for Neuroscience},
  series       = {eNeuro},
  title        = {Cognitive and Neuroanatomic Accounts of Referential Communication in Focal Dementia},
  url          = {http://dx.doi.org/10.1523/ENEURO.0488-18.2019},
  volume       = {6},
  year         = {2019},
}