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Defining neuroblastoma : From origin to precision medicine

Sainero-Alcolado, Lourdes ; Sjöberg Bexelius, Tomas ; Santopolo, Giuseppe ; Yuan, Ye ; Liaño-Pons, Judit and Arsenian-Henriksson, Marie LU (2024) In Neuro-Oncology 26(12). p.2174-2192
Abstract

Neuroblastoma (NB), a heterogenous pediatric tumor of the sympathetic nervous system, is the most common and deadly extracranial solid malignancy diagnosed in infants. Numerous efforts have been invested in understanding its origin and in development of novel curative targeted therapies. Here, we summarize the recent advances in the identification of the cell of origin and the genetic alterations occurring during development that contribute to NB. We discuss current treatment regimens, present and future directions for the identification of novel therapeutic metabolic targets, differentiation agents, as well as personalized combinatory therapies as potential approaches for improving the survival and quality of life of children with... (More)

Neuroblastoma (NB), a heterogenous pediatric tumor of the sympathetic nervous system, is the most common and deadly extracranial solid malignancy diagnosed in infants. Numerous efforts have been invested in understanding its origin and in development of novel curative targeted therapies. Here, we summarize the recent advances in the identification of the cell of origin and the genetic alterations occurring during development that contribute to NB. We discuss current treatment regimens, present and future directions for the identification of novel therapeutic metabolic targets, differentiation agents, as well as personalized combinatory therapies as potential approaches for improving the survival and quality of life of children with NB.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
immunotherapy, neural differentiation, neuroblastoma, sympathoadrenal development, targeted therapies
in
Neuro-Oncology
volume
26
issue
12
pages
19 pages
publisher
Oxford University Press
external identifiers
  • scopus:85212457240
  • pmid:39101440
ISSN
1523-5866
DOI
10.1093/neuonc/noae152
language
English
LU publication?
yes
id
f208c8ee-d8fa-4d2f-b027-af88e09ab21a
date added to LUP
2025-01-17 12:03:50
date last changed
2025-05-23 22:46:35
@article{f208c8ee-d8fa-4d2f-b027-af88e09ab21a,
  abstract     = {{<p>Neuroblastoma (NB), a heterogenous pediatric tumor of the sympathetic nervous system, is the most common and deadly extracranial solid malignancy diagnosed in infants. Numerous efforts have been invested in understanding its origin and in development of novel curative targeted therapies. Here, we summarize the recent advances in the identification of the cell of origin and the genetic alterations occurring during development that contribute to NB. We discuss current treatment regimens, present and future directions for the identification of novel therapeutic metabolic targets, differentiation agents, as well as personalized combinatory therapies as potential approaches for improving the survival and quality of life of children with NB.</p>}},
  author       = {{Sainero-Alcolado, Lourdes and Sjöberg Bexelius, Tomas and Santopolo, Giuseppe and Yuan, Ye and Liaño-Pons, Judit and Arsenian-Henriksson, Marie}},
  issn         = {{1523-5866}},
  keywords     = {{immunotherapy; neural differentiation; neuroblastoma; sympathoadrenal development; targeted therapies}},
  language     = {{eng}},
  number       = {{12}},
  pages        = {{2174--2192}},
  publisher    = {{Oxford University Press}},
  series       = {{Neuro-Oncology}},
  title        = {{Defining neuroblastoma : From origin to precision medicine}},
  url          = {{http://dx.doi.org/10.1093/neuonc/noae152}},
  doi          = {{10.1093/neuonc/noae152}},
  volume       = {{26}},
  year         = {{2024}},
}