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The feasibility of salivary sample collection in an international pediatric cohort : The the TEDDY study

Roth, Roswith; Baxter, Judith; Vehik, Kendra LU ; Hopkins, Diane; Killian, Michael; Gesualdo, Patricia; Melin, Marie Jessica LU ; Simell, Barbara; Strauss, Elisabeth and Lernmark, Åke LU , et al. (2017) In Developmental Psychobiology 59(5). p.658-667
Abstract

Saliva offers a relatively noninvasive method for measuring analytes such as cortisol, holding particular promise for use in pediatric populations on a large scale if a rigorous collection protocol is feasible in diverse settings. The Environmental Determinants of Diabetes in the Young study protocol, conducted in centers in the United States, Sweden, Finland, and Germany, used salivary collection to assess cortisol level as a physiologic marker of stress. Saliva was collected using Sorbettes from subjects at 3.5, 4.5, and 5.5 years of age. Parents collected a morning sample, and staff collected pre- and post-blood draw samples. Feasibility was assessed based on protocol completion, adherence with instructions, factors affecting... (More)

Saliva offers a relatively noninvasive method for measuring analytes such as cortisol, holding particular promise for use in pediatric populations on a large scale if a rigorous collection protocol is feasible in diverse settings. The Environmental Determinants of Diabetes in the Young study protocol, conducted in centers in the United States, Sweden, Finland, and Germany, used salivary collection to assess cortisol level as a physiologic marker of stress. Saliva was collected using Sorbettes from subjects at 3.5, 4.5, and 5.5 years of age. Parents collected a morning sample, and staff collected pre- and post-blood draw samples. Feasibility was assessed based on protocol completion, adherence with instructions, factors affecting adherence, and sufficiency of saliva sample for cortisol determination. Collection of saliva samples in a diverse pediatric population is feasible. Establishing non-invasive and acceptable methods for collecting physiological parameters of stress will allow better exploration of determinants of health in this important population.

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publication status
published
subject
keywords
adherence, methodological feasibility, multi-center international, pediatric cohort study, salivary collection, salivary cortisol
in
Developmental Psychobiology
volume
59
issue
5
pages
10 pages
external identifiers
  • scopus:85019740807
  • wos:000403067200010
ISSN
0012-1630
DOI
10.1002/dev.21523
language
English
LU publication?
yes
id
f22a6a4f-dffe-446c-aea4-273944573621
date added to LUP
2017-07-26 07:12:32
date last changed
2017-09-18 11:39:28
@article{f22a6a4f-dffe-446c-aea4-273944573621,
  abstract     = {<p>Saliva offers a relatively noninvasive method for measuring analytes such as cortisol, holding particular promise for use in pediatric populations on a large scale if a rigorous collection protocol is feasible in diverse settings. The Environmental Determinants of Diabetes in the Young study protocol, conducted in centers in the United States, Sweden, Finland, and Germany, used salivary collection to assess cortisol level as a physiologic marker of stress. Saliva was collected using Sorbettes from subjects at 3.5, 4.5, and 5.5 years of age. Parents collected a morning sample, and staff collected pre- and post-blood draw samples. Feasibility was assessed based on protocol completion, adherence with instructions, factors affecting adherence, and sufficiency of saliva sample for cortisol determination. Collection of saliva samples in a diverse pediatric population is feasible. Establishing non-invasive and acceptable methods for collecting physiological parameters of stress will allow better exploration of determinants of health in this important population.</p>},
  author       = {Roth, Roswith and Baxter, Judith and Vehik, Kendra and Hopkins, Diane and Killian, Michael and Gesualdo, Patricia and Melin, Marie Jessica and Simell, Barbara and Strauss, Elisabeth and Lernmark, Åke and Johnson, Suzanne Bennett and , },
  issn         = {0012-1630},
  keyword      = {adherence,methodological feasibility,multi-center international,pediatric cohort study,salivary collection,salivary cortisol},
  language     = {eng},
  month        = {07},
  number       = {5},
  pages        = {658--667},
  series       = {Developmental Psychobiology},
  title        = {The feasibility of salivary sample collection in an international pediatric cohort : The the TEDDY study},
  url          = {http://dx.doi.org/10.1002/dev.21523},
  volume       = {59},
  year         = {2017},
}