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High expression of CD34 and α6-integrin contributes to the cancer-initiating cell behaviour in ultraviolet-induced mouse skin squamous cell carcinoma

Ke, Hengning ; Yang, Yv Ying ; Lin, Yuan ; Liu, Li ; Sun, Jianmin LU and Massoumi, Ramin LU (2020) In Journal of Cancer 11(23). p.6760-6767
Abstract

Squamous cell carcinoma caused by ultraviolet light exposure represents over 40% of all malignant diseases. It is one of the most commonly found human tumours. Tumour mass within squamous cell carcinoma consists of various cell types, including cancer-initiating cells that are responsible for tumour progression, metastasis and chemoresistance and implicated in clinical relapse. In the present study, we aimed to characterise whether the cell population with high CD34 and α6-integrin expression behave as cancer-initiating cells within ultraviolet-induced squamous cell carcinoma in mouse skin. CD34highα6-integrinhigh compared to CD34lowα6-integrinhigh cells isolated from ultraviolet-induced squamous cell carcinoma could... (More)

Squamous cell carcinoma caused by ultraviolet light exposure represents over 40% of all malignant diseases. It is one of the most commonly found human tumours. Tumour mass within squamous cell carcinoma consists of various cell types, including cancer-initiating cells that are responsible for tumour progression, metastasis and chemoresistance and implicated in clinical relapse. In the present study, we aimed to characterise whether the cell population with high CD34 and α6-integrin expression behave as cancer-initiating cells within ultraviolet-induced squamous cell carcinoma in mouse skin. CD34highα6-integrinhigh compared to CD34lowα6-integrinhigh cells isolated from ultraviolet-induced squamous cell carcinoma could propagate effectively by displaying greater tumour initiating and self-renewal abilities. Our study suggests that CD34highα6-integrinhigh cells act as initiators upon ultraviolet-induced skin squamous cell carcinoma.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CD34, Squamous cell carcinoma, UV-B, α6-integrin
in
Journal of Cancer
volume
11
issue
23
pages
8 pages
publisher
Ivyspring International Publisher
external identifiers
  • pmid:33123267
  • scopus:85094587114
ISSN
1837-9664
DOI
10.7150/jca.45819
language
English
LU publication?
yes
id
f2732f02-344b-4109-8966-4acb6a62e542
date added to LUP
2020-11-17 10:21:58
date last changed
2024-04-03 18:08:05
@article{f2732f02-344b-4109-8966-4acb6a62e542,
  abstract     = {{<p>Squamous cell carcinoma caused by ultraviolet light exposure represents over 40% of all malignant diseases. It is one of the most commonly found human tumours. Tumour mass within squamous cell carcinoma consists of various cell types, including cancer-initiating cells that are responsible for tumour progression, metastasis and chemoresistance and implicated in clinical relapse. In the present study, we aimed to characterise whether the cell population with high CD34 and α6-integrin expression behave as cancer-initiating cells within ultraviolet-induced squamous cell carcinoma in mouse skin. CD34highα6-integrinhigh compared to CD34<sup>low</sup>α6-integrinhigh cells isolated from ultraviolet-induced squamous cell carcinoma could propagate effectively by displaying greater tumour initiating and self-renewal abilities. Our study suggests that CD34highα6-integrinhigh cells act as initiators upon ultraviolet-induced skin squamous cell carcinoma.</p>}},
  author       = {{Ke, Hengning and Yang, Yv Ying and Lin, Yuan and Liu, Li and Sun, Jianmin and Massoumi, Ramin}},
  issn         = {{1837-9664}},
  keywords     = {{CD34; Squamous cell carcinoma; UV-B; α6-integrin}},
  language     = {{eng}},
  number       = {{23}},
  pages        = {{6760--6767}},
  publisher    = {{Ivyspring International Publisher}},
  series       = {{Journal of Cancer}},
  title        = {{High expression of CD34 and α6-integrin contributes to the cancer-initiating cell behaviour in ultraviolet-induced mouse skin squamous cell carcinoma}},
  url          = {{http://dx.doi.org/10.7150/jca.45819}},
  doi          = {{10.7150/jca.45819}},
  volume       = {{11}},
  year         = {{2020}},
}