Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma
(2020) In Allergy: European Journal of Allergy and Clinical Immunology 75(12). p.3039-3068- Abstract
Modern health care requires a proactive and individualized response to diseases, combining precision diagnosis and personalized treatment. Accordingly, the approach to patients with allergic diseases encompasses novel developments in the area of personalized medicine, disease phenotyping and endotyping, and the development and application of reliable biomarkers. A detailed clinical history and physical examination followed by the detection of IgE immunoreactivity against specific allergens still represents the state of the art. However, nowadays, further emphasis focuses on the optimization of diagnostic and therapeutic standards and a large number of studies have been investigating the biomarkers of allergic diseases, including asthma,... (More)
Modern health care requires a proactive and individualized response to diseases, combining precision diagnosis and personalized treatment. Accordingly, the approach to patients with allergic diseases encompasses novel developments in the area of personalized medicine, disease phenotyping and endotyping, and the development and application of reliable biomarkers. A detailed clinical history and physical examination followed by the detection of IgE immunoreactivity against specific allergens still represents the state of the art. However, nowadays, further emphasis focuses on the optimization of diagnostic and therapeutic standards and a large number of studies have been investigating the biomarkers of allergic diseases, including asthma, atopic dermatitis, allergic rhinitis, food allergy, urticaria and anaphylaxis. Various biomarkers have been developed by omics technologies, some of which lead to a better classification of distinct phenotypes or endotypes. The introduction of biologicals to clinical practice increases the need for biomarkers for patient selection, prediction of outcomes and monitoring, to allow for an adequate choice of the duration of these costly and long-lasting therapies. Escalating healthcare costs together with questions about the efficacy of the current management of allergic diseases require further development of a biomarker-driven approach. Here, we review biomarkers in diagnosis and treatment of asthma, atopic dermatitis, allergic rhinitis, viral infections, chronic rhinosinusitis, food allergy, drug hypersensitivity and allergen immunotherapy with a special emphasis on specific IgE, the microbiome and the epithelial barrier. In addition, EAACI guidelines on biologicals are discussed within the perspective of biomarkers.
(Less)
- author
- organization
- publishing date
- 2020-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- allergen immunotherapy, allergic rhinitis, asthma phenotypes and endotypes, biomarkers, food allergy
- in
- Allergy: European Journal of Allergy and Clinical Immunology
- volume
- 75
- issue
- 12
- pages
- 30 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85091731381
- pmid:32893900
- ISSN
- 0105-4538
- DOI
- 10.1111/all.14582
- language
- English
- LU publication?
- yes
- id
- f27d2090-e4da-4608-aed6-b7764e458789
- date added to LUP
- 2020-10-27 14:30:37
- date last changed
- 2024-06-14 01:00:26
@article{f27d2090-e4da-4608-aed6-b7764e458789,
abstract = {{<p>Modern health care requires a proactive and individualized response to diseases, combining precision diagnosis and personalized treatment. Accordingly, the approach to patients with allergic diseases encompasses novel developments in the area of personalized medicine, disease phenotyping and endotyping, and the development and application of reliable biomarkers. A detailed clinical history and physical examination followed by the detection of IgE immunoreactivity against specific allergens still represents the state of the art. However, nowadays, further emphasis focuses on the optimization of diagnostic and therapeutic standards and a large number of studies have been investigating the biomarkers of allergic diseases, including asthma, atopic dermatitis, allergic rhinitis, food allergy, urticaria and anaphylaxis. Various biomarkers have been developed by omics technologies, some of which lead to a better classification of distinct phenotypes or endotypes. The introduction of biologicals to clinical practice increases the need for biomarkers for patient selection, prediction of outcomes and monitoring, to allow for an adequate choice of the duration of these costly and long-lasting therapies. Escalating healthcare costs together with questions about the efficacy of the current management of allergic diseases require further development of a biomarker-driven approach. Here, we review biomarkers in diagnosis and treatment of asthma, atopic dermatitis, allergic rhinitis, viral infections, chronic rhinosinusitis, food allergy, drug hypersensitivity and allergen immunotherapy with a special emphasis on specific IgE, the microbiome and the epithelial barrier. In addition, EAACI guidelines on biologicals are discussed within the perspective of biomarkers.</p>}},
author = {{Breiteneder, Heimo and Peng, Ya Qi and Agache, Ioana and Diamant, Zuzana and Eiwegger, Thomas and Fokkens, Wytske J. and Traidl-Hoffmann, Claudia and Nadeau, Kari and O'Hehir, Robyn E. and O'Mahony, Liam and Pfaar, Oliver and Torres, Maria J. and Wang, De Yun and Zhang, Luo and Akdis, Cezmi A.}},
issn = {{0105-4538}},
keywords = {{allergen immunotherapy; allergic rhinitis; asthma phenotypes and endotypes; biomarkers; food allergy}},
language = {{eng}},
number = {{12}},
pages = {{3039--3068}},
publisher = {{Wiley-Blackwell}},
series = {{Allergy: European Journal of Allergy and Clinical Immunology}},
title = {{Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma}},
url = {{http://dx.doi.org/10.1111/all.14582}},
doi = {{10.1111/all.14582}},
volume = {{75}},
year = {{2020}},
}