Insulin secretion : The nitric oxide controversy
(2020) In EXCLI Journal 19. p.1227-1245- Abstract
Nitric oxide (NO) is a gas that serves as a ubiquitous signaling molecule participating in physiological activities of various organ systems. Nitric oxide is produced in the endocrine pancreas and contributes to synthesis and secretion of insulin. The potential role of NO in insulin secretion is disputable – both stimulatory and inhibitory effects have been reported. Available data indicate that effects of NO critically depend on its concentration. Different isoforms of NO synthase (NOS) control this and have the potential to decrease or increase insulin secretion. In this review, the role of NO in insulin secretion as well as the possible reasons for discrepant findings are dis-cussed. A better understanding of the role of NO system in... (More)
Nitric oxide (NO) is a gas that serves as a ubiquitous signaling molecule participating in physiological activities of various organ systems. Nitric oxide is produced in the endocrine pancreas and contributes to synthesis and secretion of insulin. The potential role of NO in insulin secretion is disputable – both stimulatory and inhibitory effects have been reported. Available data indicate that effects of NO critically depend on its concentration. Different isoforms of NO synthase (NOS) control this and have the potential to decrease or increase insulin secretion. In this review, the role of NO in insulin secretion as well as the possible reasons for discrepant findings are dis-cussed. A better understanding of the role of NO system in the regulation of insulin secretion may facilitate the development of new therapeutic strategies in the management of diabetes.
(Less)
- author
- Gheibi, Sevda LU and Ghasemi, Asghar
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Insulin secretion, Insulin synthesis, Nitric oxide
- in
- EXCLI Journal
- volume
- 19
- pages
- 19 pages
- publisher
- Univ Mainz-Med Dept
- external identifiers
-
- pmid:33088259
- scopus:85090645066
- ISSN
- 1611-2156
- DOI
- 10.17179/excli2020-2711
- language
- English
- LU publication?
- yes
- id
- f2e94303-dede-451e-a9ae-2d53c2ae458b
- date added to LUP
- 2020-10-21 09:06:04
- date last changed
- 2024-07-25 02:13:20
@article{f2e94303-dede-451e-a9ae-2d53c2ae458b, abstract = {{<p>Nitric oxide (NO) is a gas that serves as a ubiquitous signaling molecule participating in physiological activities of various organ systems. Nitric oxide is produced in the endocrine pancreas and contributes to synthesis and secretion of insulin. The potential role of NO in insulin secretion is disputable – both stimulatory and inhibitory effects have been reported. Available data indicate that effects of NO critically depend on its concentration. Different isoforms of NO synthase (NOS) control this and have the potential to decrease or increase insulin secretion. In this review, the role of NO in insulin secretion as well as the possible reasons for discrepant findings are dis-cussed. A better understanding of the role of NO system in the regulation of insulin secretion may facilitate the development of new therapeutic strategies in the management of diabetes.</p>}}, author = {{Gheibi, Sevda and Ghasemi, Asghar}}, issn = {{1611-2156}}, keywords = {{Insulin secretion; Insulin synthesis; Nitric oxide}}, language = {{eng}}, pages = {{1227--1245}}, publisher = {{Univ Mainz-Med Dept}}, series = {{EXCLI Journal}}, title = {{Insulin secretion : The nitric oxide controversy}}, url = {{http://dx.doi.org/10.17179/excli2020-2711}}, doi = {{10.17179/excli2020-2711}}, volume = {{19}}, year = {{2020}}, }