Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Insulin secretion : The nitric oxide controversy

Gheibi, Sevda LU and Ghasemi, Asghar (2020) In EXCLI Journal 19. p.1227-1245
Abstract

Nitric oxide (NO) is a gas that serves as a ubiquitous signaling molecule participating in physiological activities of various organ systems. Nitric oxide is produced in the endocrine pancreas and contributes to synthesis and secretion of insulin. The potential role of NO in insulin secretion is disputable – both stimulatory and inhibitory effects have been reported. Available data indicate that effects of NO critically depend on its concentration. Different isoforms of NO synthase (NOS) control this and have the potential to decrease or increase insulin secretion. In this review, the role of NO in insulin secretion as well as the possible reasons for discrepant findings are dis-cussed. A better understanding of the role of NO system in... (More)

Nitric oxide (NO) is a gas that serves as a ubiquitous signaling molecule participating in physiological activities of various organ systems. Nitric oxide is produced in the endocrine pancreas and contributes to synthesis and secretion of insulin. The potential role of NO in insulin secretion is disputable – both stimulatory and inhibitory effects have been reported. Available data indicate that effects of NO critically depend on its concentration. Different isoforms of NO synthase (NOS) control this and have the potential to decrease or increase insulin secretion. In this review, the role of NO in insulin secretion as well as the possible reasons for discrepant findings are dis-cussed. A better understanding of the role of NO system in the regulation of insulin secretion may facilitate the development of new therapeutic strategies in the management of diabetes.

(Less)
Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Insulin secretion, Insulin synthesis, Nitric oxide
in
EXCLI Journal
volume
19
pages
19 pages
publisher
Univ Mainz-Med Dept
external identifiers
  • scopus:85090645066
  • pmid:33088259
ISSN
1611-2156
DOI
10.17179/excli2020-2711
language
English
LU publication?
yes
id
f2e94303-dede-451e-a9ae-2d53c2ae458b
date added to LUP
2020-10-21 09:06:04
date last changed
2024-05-30 23:37:22
@article{f2e94303-dede-451e-a9ae-2d53c2ae458b,
  abstract     = {{<p>Nitric oxide (NO) is a gas that serves as a ubiquitous signaling molecule participating in physiological activities of various organ systems. Nitric oxide is produced in the endocrine pancreas and contributes to synthesis and secretion of insulin. The potential role of NO in insulin secretion is disputable – both stimulatory and inhibitory effects have been reported. Available data indicate that effects of NO critically depend on its concentration. Different isoforms of NO synthase (NOS) control this and have the potential to decrease or increase insulin secretion. In this review, the role of NO in insulin secretion as well as the possible reasons for discrepant findings are dis-cussed. A better understanding of the role of NO system in the regulation of insulin secretion may facilitate the development of new therapeutic strategies in the management of diabetes.</p>}},
  author       = {{Gheibi, Sevda and Ghasemi, Asghar}},
  issn         = {{1611-2156}},
  keywords     = {{Insulin secretion; Insulin synthesis; Nitric oxide}},
  language     = {{eng}},
  pages        = {{1227--1245}},
  publisher    = {{Univ Mainz-Med Dept}},
  series       = {{EXCLI Journal}},
  title        = {{Insulin secretion : The nitric oxide controversy}},
  url          = {{http://dx.doi.org/10.17179/excli2020-2711}},
  doi          = {{10.17179/excli2020-2711}},
  volume       = {{19}},
  year         = {{2020}},
}