Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

The non-inherited maternal HLA haplotype affects the risk for type 1 diabetes

Åkesson, Kristina ; Carlsson, Annelie LU orcid ; Ivarsson, S. -A. ; Johansson, C. ; Weidby, B. -M. ; Ludvigsson, J. ; Gustavsson, Barbro LU ; Lernmark, Åke LU orcid and Kockum, I. (2009) In International Journal of Immunogenetics 36(1). p.1-8
Abstract
The aim was to test the hypothesis that the human leucocyte antigen (HLA) haplotype that is not inherited from the mother, that is, the non-inherited maternal antigen (NIMA) affects the risk for type 1 diabetes (T1D). A total of 563 children with T1D and 286 non-diabetic control children from Sweden were genotyped for DRB1, DQA1 and DQB1 alleles. The frequency of positively (DR4-DQA1*0301-B1*0302 and DR3-DQA1*0501-B1*0201), negatively (DR15-DQ A1*0102-B1*0602) or neutrally (all other) T1D associated HLA haplotypes were compared between NIMA and non-inherited paternal antigen (NIPA). All comparisons were carried out between HLA-matched patients and controls. The frequency of positively associated NIMA was higher among both DR4/X-positive... (More)
The aim was to test the hypothesis that the human leucocyte antigen (HLA) haplotype that is not inherited from the mother, that is, the non-inherited maternal antigen (NIMA) affects the risk for type 1 diabetes (T1D). A total of 563 children with T1D and 286 non-diabetic control children from Sweden were genotyped for DRB1, DQA1 and DQB1 alleles. The frequency of positively (DR4-DQA1*0301-B1*0302 and DR3-DQA1*0501-B1*0201), negatively (DR15-DQ A1*0102-B1*0602) or neutrally (all other) T1D associated HLA haplotypes were compared between NIMA and non-inherited paternal antigen (NIPA). All comparisons were carried out between HLA-matched patients and controls. The frequency of positively associated NIMA was higher among both DR4/X-positive healthy individuals compared wit DR4/X-positive patients (P < 0.00003) and DR3/X-positive healthy individuals compared with DR3/X-positive patients (P < 0.009). No such difference was observed for NIPA. High-risk NIMA was increased compared to NIPA among healthy DR3/X- and DR4/X-positive children (P < 0.05). There was no difference in frequency of positively associated haplotypes between patient NIMA and NIPA. The NIMA but not the NIPA affects the risk for T1D, suggesting that not only the inherited but also non-inherited maternal HLA haplotypes, perhaps through microchimerism or other mechanisms, may influence the risk for the disease. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Immunogenetics
volume
36
issue
1
pages
1 - 8
publisher
Wiley-Blackwell
external identifiers
  • wos:000262667000001
  • scopus:58849167380
ISSN
1744-3121
DOI
10.1111/j.1744-313X.2008.00802.x
language
English
LU publication?
yes
id
f312c8f3-c67b-4bae-a8af-34c942c58556 (old id 1312210)
date added to LUP
2016-04-01 11:36:21
date last changed
2024-01-07 13:39:13
@article{f312c8f3-c67b-4bae-a8af-34c942c58556,
  abstract     = {{The aim was to test the hypothesis that the human leucocyte antigen (HLA) haplotype that is not inherited from the mother, that is, the non-inherited maternal antigen (NIMA) affects the risk for type 1 diabetes (T1D). A total of 563 children with T1D and 286 non-diabetic control children from Sweden were genotyped for DRB1, DQA1 and DQB1 alleles. The frequency of positively (DR4-DQA1*0301-B1*0302 and DR3-DQA1*0501-B1*0201), negatively (DR15-DQ A1*0102-B1*0602) or neutrally (all other) T1D associated HLA haplotypes were compared between NIMA and non-inherited paternal antigen (NIPA). All comparisons were carried out between HLA-matched patients and controls. The frequency of positively associated NIMA was higher among both DR4/X-positive healthy individuals compared wit DR4/X-positive patients (P &lt; 0.00003) and DR3/X-positive healthy individuals compared with DR3/X-positive patients (P &lt; 0.009). No such difference was observed for NIPA. High-risk NIMA was increased compared to NIPA among healthy DR3/X- and DR4/X-positive children (P &lt; 0.05). There was no difference in frequency of positively associated haplotypes between patient NIMA and NIPA. The NIMA but not the NIPA affects the risk for T1D, suggesting that not only the inherited but also non-inherited maternal HLA haplotypes, perhaps through microchimerism or other mechanisms, may influence the risk for the disease.}},
  author       = {{Åkesson, Kristina and Carlsson, Annelie and Ivarsson, S. -A. and Johansson, C. and Weidby, B. -M. and Ludvigsson, J. and Gustavsson, Barbro and Lernmark, Åke and Kockum, I.}},
  issn         = {{1744-3121}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{1--8}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{International Journal of Immunogenetics}},
  title        = {{The non-inherited maternal HLA haplotype affects the risk for type 1 diabetes}},
  url          = {{http://dx.doi.org/10.1111/j.1744-313X.2008.00802.x}},
  doi          = {{10.1111/j.1744-313X.2008.00802.x}},
  volume       = {{36}},
  year         = {{2009}},
}