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Chronic Inflammation and Atherosclerosis

Nilsson, Jan LU ; Gonçalves, Isabel LU orcid and Edsfeldt, Andreas LU (2015) p.157-167
Abstract

Inflammation is a vital response and necessary for maintaining homeostasis. Inflammation protects against tissue damage and pathogens-but is also one of the main driving forces of the atherosclerotic plaque progression. How and why the inflammatory response is initiated in the atherosclerotic disease is not fully known, but evidence suggests modified lipids as potential antigens activating the immune response, according to the response-to-retention theory. The inflammatory response is an intricate interplay between the innate and adaptive immune system, tightly regulated by pro-inflammatory and anti-inflammatory mechanisms. Besides its role in the formation of the atherosclerotic plaque many studies also point toward inflammation as a... (More)

Inflammation is a vital response and necessary for maintaining homeostasis. Inflammation protects against tissue damage and pathogens-but is also one of the main driving forces of the atherosclerotic plaque progression. How and why the inflammatory response is initiated in the atherosclerotic disease is not fully known, but evidence suggests modified lipids as potential antigens activating the immune response, according to the response-to-retention theory. The inflammatory response is an intricate interplay between the innate and adaptive immune system, tightly regulated by pro-inflammatory and anti-inflammatory mechanisms. Besides its role in the formation of the atherosclerotic plaque many studies also point toward inflammation as a driving force of plaque vulnerability and eventually plaque rupture.

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Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
B-cell, Cytokine, Inflammation, Macrophage, Risk factor, T-cell
host publication
Early Vascular Aging (EVA) : New Directions in Cardiovascular Protection - New Directions in Cardiovascular Protection
editor
Nilsson, Peter M. ; Olsen, Michael H. and Laurent, Stéphane
pages
11 pages
publisher
Elsevier Science Publishers B.V.
external identifiers
  • scopus:85072327192
ISBN
9780128016763
9780128013878
DOI
10.1016/B978-0-12-801387-8.00016-8
language
English
LU publication?
yes
id
f324004e-48e2-47b5-9838-eda39560ae44
date added to LUP
2019-09-30 15:52:22
date last changed
2024-06-12 02:20:14
@inbook{f324004e-48e2-47b5-9838-eda39560ae44,
  abstract     = {{<p>Inflammation is a vital response and necessary for maintaining homeostasis. Inflammation protects against tissue damage and pathogens-but is also one of the main driving forces of the atherosclerotic plaque progression. How and why the inflammatory response is initiated in the atherosclerotic disease is not fully known, but evidence suggests modified lipids as potential antigens activating the immune response, according to the response-to-retention theory. The inflammatory response is an intricate interplay between the innate and adaptive immune system, tightly regulated by pro-inflammatory and anti-inflammatory mechanisms. Besides its role in the formation of the atherosclerotic plaque many studies also point toward inflammation as a driving force of plaque vulnerability and eventually plaque rupture.</p>}},
  author       = {{Nilsson, Jan and Gonçalves, Isabel and Edsfeldt, Andreas}},
  booktitle    = {{Early Vascular Aging (EVA) : New Directions in Cardiovascular Protection}},
  editor       = {{Nilsson, Peter M. and Olsen, Michael H. and Laurent, Stéphane}},
  isbn         = {{9780128016763}},
  keywords     = {{B-cell; Cytokine; Inflammation; Macrophage; Risk factor; T-cell}},
  language     = {{eng}},
  month        = {{01}},
  pages        = {{157--167}},
  publisher    = {{Elsevier Science Publishers B.V.}},
  title        = {{Chronic Inflammation and Atherosclerosis}},
  url          = {{http://dx.doi.org/10.1016/B978-0-12-801387-8.00016-8}},
  doi          = {{10.1016/B978-0-12-801387-8.00016-8}},
  year         = {{2015}},
}