Chronic Inflammation and Atherosclerosis
Nilsson, Jan LU ; Gonçalves, Isabel LU
and Edsfeldt, Andreas
LU
(2015)
p.157-167
- Abstract
Inflammation is a vital response and necessary for maintaining homeostasis. Inflammation protects against tissue damage and pathogens-but is also one of the main driving forces of the atherosclerotic plaque progression. How and why the inflammatory response is initiated in the atherosclerotic disease is not fully known, but evidence suggests modified lipids as potential antigens activating the immune response, according to the response-to-retention theory. The inflammatory response is an intricate interplay between the innate and adaptive immune system, tightly regulated by pro-inflammatory and anti-inflammatory mechanisms. Besides its role in the formation of the atherosclerotic plaque many studies also point toward inflammation as a... (More)
Inflammation is a vital response and necessary for maintaining homeostasis. Inflammation protects against tissue damage and pathogens-but is also one of the main driving forces of the atherosclerotic plaque progression. How and why the inflammatory response is initiated in the atherosclerotic disease is not fully known, but evidence suggests modified lipids as potential antigens activating the immune response, according to the response-to-retention theory. The inflammatory response is an intricate interplay between the innate and adaptive immune system, tightly regulated by pro-inflammatory and anti-inflammatory mechanisms. Besides its role in the formation of the atherosclerotic plaque many studies also point toward inflammation as a driving force of plaque vulnerability and eventually plaque rupture.
(Less)
- author
- Nilsson, Jan
LU
; Gonçalves, Isabel
LU
and Edsfeldt, Andreas
LU
- organization
- publishing date
- 2015-01-01
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- B-cell, Cytokine, Inflammation, Macrophage, Risk factor, T-cell
- host publication
- Early Vascular Aging (EVA) : New Directions in Cardiovascular Protection - New Directions in Cardiovascular Protection
- editor
- Nilsson, Peter M. ; Olsen, Michael H. and Laurent, Stéphane
- pages
- 11 pages
- publisher
- Elsevier Science Publishers B.V.
- external identifiers
-
- scopus:85072327192
- ISBN
- 9780128016763
- 9780128013878
- DOI
- 10.1016/B978-0-12-801387-8.00016-8
- language
- English
- LU publication?
- yes
- id
- f324004e-48e2-47b5-9838-eda39560ae44
- date added to LUP
- 2019-09-30 15:52:22
- date last changed
- 2025-01-10 00:04:32
@inbook{f324004e-48e2-47b5-9838-eda39560ae44,
abstract = {{<p>Inflammation is a vital response and necessary for maintaining homeostasis. Inflammation protects against tissue damage and pathogens-but is also one of the main driving forces of the atherosclerotic plaque progression. How and why the inflammatory response is initiated in the atherosclerotic disease is not fully known, but evidence suggests modified lipids as potential antigens activating the immune response, according to the response-to-retention theory. The inflammatory response is an intricate interplay between the innate and adaptive immune system, tightly regulated by pro-inflammatory and anti-inflammatory mechanisms. Besides its role in the formation of the atherosclerotic plaque many studies also point toward inflammation as a driving force of plaque vulnerability and eventually plaque rupture.</p>}},
author = {{Nilsson, Jan and Gonçalves, Isabel and Edsfeldt, Andreas}},
booktitle = {{Early Vascular Aging (EVA) : New Directions in Cardiovascular Protection}},
editor = {{Nilsson, Peter M. and Olsen, Michael H. and Laurent, Stéphane}},
isbn = {{9780128016763}},
keywords = {{B-cell; Cytokine; Inflammation; Macrophage; Risk factor; T-cell}},
language = {{eng}},
month = {{01}},
pages = {{157--167}},
publisher = {{Elsevier Science Publishers B.V.}},
title = {{Chronic Inflammation and Atherosclerosis}},
url = {{http://dx.doi.org/10.1016/B978-0-12-801387-8.00016-8}},
doi = {{10.1016/B978-0-12-801387-8.00016-8}},
year = {{2015}},
}