Hunting out the autophagic problem in Huntington disease
Pircs, Karolina LU
; Barker, Roger A.
LU
and Jakobsson, Johan
LU
(2022)
In Autophagy
18(12).
p.3031-3032
- Abstract
Huntington disease is an inherited, progressive, incurable neurodegenerative disorder that primarily affects cells in the brain. Although the genetic basis for this condition has been known for nearly 30 years, how this causes disease is still unresolved. Of late there has been increasing evidence suggesting that dysfunction in macroautophagic/autophagic pathways may contribute to cellular dysfunction and death. In our recent work we highlight more precisely how and where this problem might arise in this pathway using directly reprogrammed neurons.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/f35df9cb-a1dc-486f-b4de-7764deec474b
- author
- Pircs, Karolina
LU
; Barker, Roger A.
LU
and Jakobsson, Johan
LU
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Autophagy, CRISPR, huntington disease, induced neurons, lentiviral vector, macroautophagy, neurodegenerative diseases, reprogramming
- in
- Autophagy
- volume
- 18
- issue
- 12
- pages
- 3031 - 3032
- publisher
- Landes Bioscience
- external identifiers
-
- pmid:35468035
- scopus:85132665837
- ISSN
- 1554-8627
- DOI
- 10.1080/15548627.2022.2069438
- language
- English
- LU publication?
- yes
- id
- f35df9cb-a1dc-486f-b4de-7764deec474b
- date added to LUP
- 2022-09-05 11:16:45
- date last changed
- 2024-04-18 13:35:45
@misc{f35df9cb-a1dc-486f-b4de-7764deec474b,
abstract = {{<p>Huntington disease is an inherited, progressive, incurable neurodegenerative disorder that primarily affects cells in the brain. Although the genetic basis for this condition has been known for nearly 30 years, how this causes disease is still unresolved. Of late there has been increasing evidence suggesting that dysfunction in macroautophagic/autophagic pathways may contribute to cellular dysfunction and death. In our recent work we highlight more precisely how and where this problem might arise in this pathway using directly reprogrammed neurons.</p>}},
author = {{Pircs, Karolina and Barker, Roger A. and Jakobsson, Johan}},
issn = {{1554-8627}},
keywords = {{Autophagy; CRISPR; huntington disease; induced neurons; lentiviral vector; macroautophagy; neurodegenerative diseases; reprogramming}},
language = {{eng}},
number = {{12}},
pages = {{3031--3032}},
publisher = {{Landes Bioscience}},
series = {{Autophagy}},
title = {{Hunting out the autophagic problem in Huntington disease}},
url = {{http://dx.doi.org/10.1080/15548627.2022.2069438}},
doi = {{10.1080/15548627.2022.2069438}},
volume = {{18}},
year = {{2022}},
}