Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Circulating biomarkers in pulmonary arterial hypertension: State-of-the-art review and future directions

Ahmed, Salaheldin LU orcid ; Ahmed, Abdulla LU orcid and Rådegran, Göran LU (2024) In JHLT Open 6.
Abstract
Pulmonary arterial hypertension is a complex and heterogeneous condition, associated with a considerable diagnostic delay, diminished exercise capacity, and poor outcomes. In pulmonary arterial hypertension, biomarker research has become a subject of intense inquiry, and novel circulating biomarkers acknowledged in a multitude of mechanistic pathways are emerging. Beyond the widely used natriuretic peptides, novel biomarkers may provide deeper pathophysiological understanding, support clinical decision-making, and prompt the incorporation of precision medicine by enabling a more precise individual phenotyping. In this state-of-the-art review, the recent advances in circulating biomarkers in pulmonary arterial hypertension from a clinical... (More)
Pulmonary arterial hypertension is a complex and heterogeneous condition, associated with a considerable diagnostic delay, diminished exercise capacity, and poor outcomes. In pulmonary arterial hypertension, biomarker research has become a subject of intense inquiry, and novel circulating biomarkers acknowledged in a multitude of mechanistic pathways are emerging. Beyond the widely used natriuretic peptides, novel biomarkers may provide deeper pathophysiological understanding, support clinical decision-making, and prompt the incorporation of precision medicine by enabling a more precise individual phenotyping. In this state-of-the-art review, the recent advances in circulating biomarkers in pulmonary arterial hypertension from a clinical perspective are discussed, with particular emphasis on the current state of knowledge, gaps in evidence, and future perspectives. (Less)
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
JHLT Open
volume
6
article number
100152
publisher
Elsevier
external identifiers
  • pmid:40145036
ISSN
2950-1334
DOI
10.1016/j.jhlto.2024.100152
language
English
LU publication?
yes
id
f391e616-6dd7-4410-a596-2e6ac672d559
date added to LUP
2025-03-26 14:06:48
date last changed
2025-06-26 03:00:17
@article{f391e616-6dd7-4410-a596-2e6ac672d559,
  abstract     = {{Pulmonary arterial hypertension is a complex and heterogeneous condition, associated with a considerable diagnostic delay, diminished exercise capacity, and poor outcomes. In pulmonary arterial hypertension, biomarker research has become a subject of intense inquiry, and novel circulating biomarkers acknowledged in a multitude of mechanistic pathways are emerging. Beyond the widely used natriuretic peptides, novel biomarkers may provide deeper pathophysiological understanding, support clinical decision-making, and prompt the incorporation of precision medicine by enabling a more precise individual phenotyping. In this state-of-the-art review, the recent advances in circulating biomarkers in pulmonary arterial hypertension from a clinical perspective are discussed, with particular emphasis on the current state of knowledge, gaps in evidence, and future perspectives.}},
  author       = {{Ahmed, Salaheldin and Ahmed, Abdulla and Rådegran, Göran}},
  issn         = {{2950-1334}},
  language     = {{eng}},
  month        = {{11}},
  publisher    = {{Elsevier}},
  series       = {{JHLT Open}},
  title        = {{Circulating biomarkers in pulmonary arterial hypertension: State-of-the-art review and future directions}},
  url          = {{http://dx.doi.org/10.1016/j.jhlto.2024.100152}},
  doi          = {{10.1016/j.jhlto.2024.100152}},
  volume       = {{6}},
  year         = {{2024}},
}