Lipid-Associated Variants near ANGPTL3 and LPL Show Parent-of-Origin Specific Effects on Blood Lipid Levels and Obesity
(2022) In Genes 13(1). p.1-15- Abstract
- Parent-of-origin effects (POE) and sex-specific parental effects have been reported for plasma lipid levels, and a strong relationship exists between dyslipidemia and obesity. We aim to explore whether genetic variants previously reported to have an association to lipid traits also show POE on blood lipid levels and obesity. Families from the Botnia cohort and the Hungarian Transdanubian Biobank (HTB) were genotyped for 12 SNPs, parental origin of alleles were inferred, and generalized estimating equations were modeled to assess parental-specific associations with lipid traits and obesity. POE were observed for the variants at the TMEM57, DOCK7/ANGPTL3, LPL, and APOA on lipid traits, the latter replicated in HTB. Sex-specific parental... (More)
- Parent-of-origin effects (POE) and sex-specific parental effects have been reported for plasma lipid levels, and a strong relationship exists between dyslipidemia and obesity. We aim to explore whether genetic variants previously reported to have an association to lipid traits also show POE on blood lipid levels and obesity. Families from the Botnia cohort and the Hungarian Transdanubian Biobank (HTB) were genotyped for 12 SNPs, parental origin of alleles were inferred, and generalized estimating equations were modeled to assess parental-specific associations with lipid traits and obesity. POE were observed for the variants at the TMEM57, DOCK7/ANGPTL3, LPL, and APOA on lipid traits, the latter replicated in HTB. Sex-specific parental effects were also observed; variants at ANGPTL3/DOCK7 showed POE on lipid traits and obesity in daughters only, while those at LPL and TMEM57 showed POE on lipid traits in sons. Variants at LPL and DOCK7/ANGPTL3 showed POE on obesity-related traits in Botnia and HTB, and POE effects on obesity were seen to a higher degree in daughters. This highlights the need to include analysis of POEs in genetic studies of complex traits. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/f3a8e4e8-3597-4a5e-865d-3a5462c9ad64
- author
- Lessmark, Anna LU ; Hatem, Gad LU ; Kovacs, Györgyi ; Vitai, Marta ; Ahlqvist, Emma LU ; Tuomi, Tiinamaija LU ; Koranyi, Laszlo ; Groop, Leif LU and Prasad, Rashmi B. LU
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Genes
- volume
- 13
- issue
- 1
- article number
- 91
- pages
- 1 - 15
- publisher
- MDPI AG
- external identifiers
-
- scopus:85122004777
- pmid:35052431
- ISSN
- 2073-4425
- DOI
- 10.3390/genes13010091
- language
- English
- LU publication?
- yes
- id
- f3a8e4e8-3597-4a5e-865d-3a5462c9ad64
- date added to LUP
- 2022-01-17 11:29:51
- date last changed
- 2024-05-04 20:08:18
@article{f3a8e4e8-3597-4a5e-865d-3a5462c9ad64, abstract = {{Parent-of-origin effects (POE) and sex-specific parental effects have been reported for plasma lipid levels, and a strong relationship exists between dyslipidemia and obesity. We aim to explore whether genetic variants previously reported to have an association to lipid traits also show POE on blood lipid levels and obesity. Families from the Botnia cohort and the Hungarian Transdanubian Biobank (HTB) were genotyped for 12 SNPs, parental origin of alleles were inferred, and generalized estimating equations were modeled to assess parental-specific associations with lipid traits and obesity. POE were observed for the variants at the TMEM57, DOCK7/ANGPTL3, LPL, and APOA on lipid traits, the latter replicated in HTB. Sex-specific parental effects were also observed; variants at ANGPTL3/DOCK7 showed POE on lipid traits and obesity in daughters only, while those at LPL and TMEM57 showed POE on lipid traits in sons. Variants at LPL and DOCK7/ANGPTL3 showed POE on obesity-related traits in Botnia and HTB, and POE effects on obesity were seen to a higher degree in daughters. This highlights the need to include analysis of POEs in genetic studies of complex traits.}}, author = {{Lessmark, Anna and Hatem, Gad and Kovacs, Györgyi and Vitai, Marta and Ahlqvist, Emma and Tuomi, Tiinamaija and Koranyi, Laszlo and Groop, Leif and Prasad, Rashmi B.}}, issn = {{2073-4425}}, language = {{eng}}, number = {{1}}, pages = {{1--15}}, publisher = {{MDPI AG}}, series = {{Genes}}, title = {{Lipid-Associated Variants near ANGPTL3 and LPL Show Parent-of-Origin Specific Effects on Blood Lipid Levels and Obesity}}, url = {{http://dx.doi.org/10.3390/genes13010091}}, doi = {{10.3390/genes13010091}}, volume = {{13}}, year = {{2022}}, }