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Lipid-Associated Variants near ANGPTL3 and LPL Show Parent-of-Origin Specific Effects on Blood Lipid Levels and Obesity

Lessmark, Anna LU ; Hatem, Gad LU ; Kovacs, Györgyi ; Vitai, Marta ; Ahlqvist, Emma LU ; Tuomi, Tiinamaija LU orcid ; Koranyi, Laszlo ; Groop, Leif LU and Prasad, Rashmi B. LU (2022) In Genes 13(1). p.1-15
Abstract
Parent-of-origin effects (POE) and sex-specific parental effects have been reported for plasma lipid levels, and a strong relationship exists between dyslipidemia and obesity. We aim to explore whether genetic variants previously reported to have an association to lipid traits also show POE on blood lipid levels and obesity. Families from the Botnia cohort and the Hungarian Transdanubian Biobank (HTB) were genotyped for 12 SNPs, parental origin of alleles were inferred, and generalized estimating equations were modeled to assess parental-specific associations with lipid traits and obesity. POE were observed for the variants at the TMEM57, DOCK7/ANGPTL3, LPL, and APOA on lipid traits, the latter replicated in HTB. Sex-specific parental... (More)
Parent-of-origin effects (POE) and sex-specific parental effects have been reported for plasma lipid levels, and a strong relationship exists between dyslipidemia and obesity. We aim to explore whether genetic variants previously reported to have an association to lipid traits also show POE on blood lipid levels and obesity. Families from the Botnia cohort and the Hungarian Transdanubian Biobank (HTB) were genotyped for 12 SNPs, parental origin of alleles were inferred, and generalized estimating equations were modeled to assess parental-specific associations with lipid traits and obesity. POE were observed for the variants at the TMEM57, DOCK7/ANGPTL3, LPL, and APOA on lipid traits, the latter replicated in HTB. Sex-specific parental effects were also observed; variants at ANGPTL3/DOCK7 showed POE on lipid traits and obesity in daughters only, while those at LPL and TMEM57 showed POE on lipid traits in sons. Variants at LPL and DOCK7/ANGPTL3 showed POE on obesity-related traits in Botnia and HTB, and POE effects on obesity were seen to a higher degree in daughters. This highlights the need to include analysis of POEs in genetic studies of complex traits. (Less)
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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Genes
volume
13
issue
1
article number
91
pages
1 - 15
publisher
MDPI AG
external identifiers
  • scopus:85122004777
  • pmid:35052431
ISSN
2073-4425
DOI
10.3390/genes13010091
language
English
LU publication?
yes
id
f3a8e4e8-3597-4a5e-865d-3a5462c9ad64
date added to LUP
2022-01-17 11:29:51
date last changed
2024-05-04 20:08:18
@article{f3a8e4e8-3597-4a5e-865d-3a5462c9ad64,
  abstract     = {{Parent-of-origin effects (POE) and sex-specific parental effects have been reported for plasma lipid levels, and a strong relationship exists between dyslipidemia and obesity. We aim to explore whether genetic variants previously reported to have an association to lipid traits also show POE on blood lipid levels and obesity. Families from the Botnia cohort and the Hungarian Transdanubian Biobank (HTB) were genotyped for 12 SNPs, parental origin of alleles were inferred, and generalized estimating equations were modeled to assess parental-specific associations with lipid traits and obesity. POE were observed for the variants at the TMEM57, DOCK7/ANGPTL3, LPL, and APOA on lipid traits, the latter replicated in HTB. Sex-specific parental effects were also observed; variants at ANGPTL3/DOCK7 showed POE on lipid traits and obesity in daughters only, while those at LPL and TMEM57 showed POE on lipid traits in sons. Variants at LPL and DOCK7/ANGPTL3 showed POE on obesity-related traits in Botnia and HTB, and POE effects on obesity were seen to a higher degree in daughters. This highlights the need to include analysis of POEs in genetic studies of complex traits.}},
  author       = {{Lessmark, Anna and Hatem, Gad and Kovacs, Györgyi and Vitai, Marta and Ahlqvist, Emma and Tuomi, Tiinamaija and Koranyi, Laszlo and Groop, Leif and Prasad, Rashmi B.}},
  issn         = {{2073-4425}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{1--15}},
  publisher    = {{MDPI AG}},
  series       = {{Genes}},
  title        = {{Lipid-Associated Variants near ANGPTL3 and LPL Show Parent-of-Origin Specific Effects on Blood Lipid Levels and Obesity}},
  url          = {{http://dx.doi.org/10.3390/genes13010091}},
  doi          = {{10.3390/genes13010091}},
  volume       = {{13}},
  year         = {{2022}},
}