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Control of Dissolved Oxygen in Stirred Bioreactors

Åkesson, Mats LU and Hagander, Per LU (1998) In Technical Reports TFRT-7571
Abstract
This report discusses control of dissolved oxygen in a bioreactor where the oxygen supply is manipulated using the stirrer speed. In batch and fed-batch cultivations the operating conditions change significantly which may cause tuning problems. Analysis using a linearized process model shows that the process dynamics is mainly affected by changes in the volumetric oxygen transfer coefficient $K_La$. % To account for the process variations, a control strategy based on PID control and gain scheduling from the stirrer speed is suggested. This approach is straightforward to implement in an industrial control system. Experimental results from a laboratory reactor are presented.
Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Book/Report
publication status
published
subject
keywords
Feedback control, dissolved oxygen, stirrer speed, bioreactor, gain scheduling.
in
Technical Reports TFRT-7571
publisher
Department of Automatic Control, Lund Institute of Technology (LTH)
ISSN
0280-5316
language
English
LU publication?
yes
id
f3be4419-484f-4bd8-85a5-b233bf67eb2a (old id 8602746)
date added to LUP
2016-04-01 16:45:25
date last changed
2025-04-04 13:59:42
@techreport{f3be4419-484f-4bd8-85a5-b233bf67eb2a,
  abstract     = {{This report discusses control of dissolved oxygen in a bioreactor where the oxygen supply is manipulated using the stirrer speed. In batch and fed-batch cultivations the operating conditions change significantly which may cause tuning problems. Analysis using a linearized process model shows that the process dynamics is mainly affected by changes in the volumetric oxygen transfer coefficient $K_La$. % To account for the process variations, a control strategy based on PID control and gain scheduling from the stirrer speed is suggested. This approach is straightforward to implement in an industrial control system. Experimental results from a laboratory reactor are presented.}},
  author       = {{Åkesson, Mats and Hagander, Per}},
  institution  = {{Department of Automatic Control, Lund Institute of Technology (LTH)}},
  issn         = {{0280-5316}},
  keywords     = {{Feedback control; dissolved oxygen; stirrer speed; bioreactor; gain scheduling.}},
  language     = {{eng}},
  series       = {{Technical Reports TFRT-7571}},
  title        = {{Control of Dissolved Oxygen in Stirred Bioreactors}},
  url          = {{https://lup.lub.lu.se/search/files/4770852/8727192.pdf}},
  year         = {{1998}},
}