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Metabolic profiling and targeted lipidomics reveals a disturbed lipid profile in mothers and fetuses with intrauterine growth restriction

Miranda, Jezid ; Simões, Rui V. ; Paules, Cristina ; Cañueto, Daniel ; Pardo-Cea, Miguel A. ; García-Martín, María L. ; Crovetto, Francesca ; Fuertes-Martin, Rocio ; Domenech, Monica and Gómez-Roig, María D. , et al. (2018) In Scientific Reports 8(1).
Abstract

Fetal growth may be impaired by poor placental function or maternal conditions, each of which can influence the transfer of nutrients and oxygen from the mother to the developing fetus. Large-scale studies of metabolites (metabolomics) are key to understand cellular metabolism and pathophysiology of human conditions. Herein, maternal and cord blood plasma samples were used for NMR-based metabolic fingerprinting and profiling, including analysis of the enrichment of circulating lipid classes and subclasses, as well as the number of sub-fraction particles and their size. Changes in phosphatidylcholines and glycoproteins were prominent in growth-restricted fetuses indicating significant alterations in their abundance and biophysical... (More)

Fetal growth may be impaired by poor placental function or maternal conditions, each of which can influence the transfer of nutrients and oxygen from the mother to the developing fetus. Large-scale studies of metabolites (metabolomics) are key to understand cellular metabolism and pathophysiology of human conditions. Herein, maternal and cord blood plasma samples were used for NMR-based metabolic fingerprinting and profiling, including analysis of the enrichment of circulating lipid classes and subclasses, as well as the number of sub-fraction particles and their size. Changes in phosphatidylcholines and glycoproteins were prominent in growth-restricted fetuses indicating significant alterations in their abundance and biophysical properties. Lipoprotein profiles showed significantly lower plasma concentrations of cholesterol-intermediate density lipoprotein (IDL), triglycerides-IDL and high-density lipoprotein (HDL) in mothers of growth-restricted fetuses compared to controls (p < 0.05). In contrast, growth-restricted fetuses had significantly higher plasma concentrations of cholesterol and triglycerides transporting lipoproteins [LDL, IDL, and VLDL, (p < 0.005; all)], as well as increased VLDL particle types (large, medium and small). Significant changes in plasma concentrations of formate, histidine, isoleucine and citrate in growth-restricted fetuses were also observed. Comprehensive metabolic profiling reveals that both, mother and fetuses of pregnancies complicated with fetal growth restriction have a substantial disruption in lipid metabolism.

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Contribution to journal
publication status
published
subject
in
Scientific Reports
volume
8
issue
1
article number
13614
publisher
Nature Publishing Group
external identifiers
  • scopus:85053231746
  • pmid:30206284
ISSN
2045-2322
DOI
10.1038/s41598-018-31832-5
language
English
LU publication?
yes
id
f3cd6d99-7847-46d1-ae4a-89e1f1ff02a3
date added to LUP
2018-10-08 13:57:38
date last changed
2021-10-06 02:09:25
@article{f3cd6d99-7847-46d1-ae4a-89e1f1ff02a3,
  abstract     = {<p>Fetal growth may be impaired by poor placental function or maternal conditions, each of which can influence the transfer of nutrients and oxygen from the mother to the developing fetus. Large-scale studies of metabolites (metabolomics) are key to understand cellular metabolism and pathophysiology of human conditions. Herein, maternal and cord blood plasma samples were used for NMR-based metabolic fingerprinting and profiling, including analysis of the enrichment of circulating lipid classes and subclasses, as well as the number of sub-fraction particles and their size. Changes in phosphatidylcholines and glycoproteins were prominent in growth-restricted fetuses indicating significant alterations in their abundance and biophysical properties. Lipoprotein profiles showed significantly lower plasma concentrations of cholesterol-intermediate density lipoprotein (IDL), triglycerides-IDL and high-density lipoprotein (HDL) in mothers of growth-restricted fetuses compared to controls (p &lt; 0.05). In contrast, growth-restricted fetuses had significantly higher plasma concentrations of cholesterol and triglycerides transporting lipoproteins [LDL, IDL, and VLDL, (p &lt; 0.005; all)], as well as increased VLDL particle types (large, medium and small). Significant changes in plasma concentrations of formate, histidine, isoleucine and citrate in growth-restricted fetuses were also observed. Comprehensive metabolic profiling reveals that both, mother and fetuses of pregnancies complicated with fetal growth restriction have a substantial disruption in lipid metabolism.</p>},
  author       = {Miranda, Jezid and Simões, Rui V. and Paules, Cristina and Cañueto, Daniel and Pardo-Cea, Miguel A. and García-Martín, María L. and Crovetto, Francesca and Fuertes-Martin, Rocio and Domenech, Monica and Gómez-Roig, María D. and Eixarch, Elisenda and Estruch, Ramon and Hansson, Stefan R. and Amigó, Nuria and Cañellas, Nicolau and Crispi, Fatima and Gratacós, Eduard},
  issn         = {2045-2322},
  language     = {eng},
  number       = {1},
  publisher    = {Nature Publishing Group},
  series       = {Scientific Reports},
  title        = {Metabolic profiling and targeted lipidomics reveals a disturbed lipid profile in mothers and fetuses with intrauterine growth restriction},
  url          = {http://dx.doi.org/10.1038/s41598-018-31832-5},
  doi          = {10.1038/s41598-018-31832-5},
  volume       = {8},
  year         = {2018},
}