Multi-centre evaluation of accuracy and reproducibility of planar and SPECT image quantification : An IAEA phantom study
(2017) In Zeitschrift für Medizinische Physik 27(2). p.98-112- Abstract
Accurate quantitation of activity provides the basis for internal dosimetry of targeted radionuclide therapies. This study investigated quantitative imaging capabilities at sites with a variety of experience and equipment and assessed levels of errors in activity quantitation in Single-Photon Emission Computed Tomography (SPECT) and planar imaging. Participants from 9 countries took part in a comparison in which planar, SPECT and SPECT with X ray computed tomography (SPECT-CT) imaging were used to quantify activities of four epoxy-filled cylinders containing 133Ba, which was chosen as a surrogate for 131I. The sources, with nominal volumes of 2, 4, 6 and 23mL, were calibrated for 133Ba activity by the National Institute of Standards and... (More)
Accurate quantitation of activity provides the basis for internal dosimetry of targeted radionuclide therapies. This study investigated quantitative imaging capabilities at sites with a variety of experience and equipment and assessed levels of errors in activity quantitation in Single-Photon Emission Computed Tomography (SPECT) and planar imaging. Participants from 9 countries took part in a comparison in which planar, SPECT and SPECT with X ray computed tomography (SPECT-CT) imaging were used to quantify activities of four epoxy-filled cylinders containing 133Ba, which was chosen as a surrogate for 131I. The sources, with nominal volumes of 2, 4, 6 and 23mL, were calibrated for 133Ba activity by the National Institute of Standards and Technology, but the activity was initially unknown to the participants. Imaging was performed in a cylindrical phantom filled with water. Two trials were carried out in which the participants first estimated the activities using their local standard protocols, and then repeated the measurements using a standardized acquisition and analysis protocol. Finally, processing of the imaging data from the second trial was repeated by a single centre using a fixed protocol. In the first trial, the activities were underestimated by about 15% with planar imaging. SPECT with Chang's first order attenuation correction (Chang-AC) and SPECT-CT overestimated the activity by about 10%. The second trial showed moderate improvements in accuracy and variability. Planar imaging was subject to methodological errors, e.g., in the use of a transmission scan for attenuation correction. The use of Chang-AC was subject to variability from the definition of phantom contours. The project demonstrated the need for training and standardized protocols to achieve good levels of quantitative accuracy and precision in a multicentre setting. Absolute quantification of simple objects with no background was possible with the strictest protocol to about 6% with planar imaging and SPECT (with Chang-AC) and within 2% for SPECT-CT.
(Less)
- author
- organization
- publishing date
- 2017-06
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Humans, Image Processing, Computer-Assisted, Phantoms, Imaging/standards, Radiometry, Reproducibility of Results, Tomography, Emission-Computed, Single-Photon/methods
- in
- Zeitschrift für Medizinische Physik
- volume
- 27
- issue
- 2
- pages
- 15 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:27105765
- scopus:84963811404
- ISSN
- 1876-4436
- DOI
- 10.1016/j.zemedi.2016.03.008
- language
- English
- LU publication?
- yes
- additional info
- Copyright © 2016. Published by Elsevier GmbH.
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- f3ea9f11-6de7-4972-865c-8f4790bbf537
- date added to LUP
- 2019-05-09 15:40:33
- date last changed
- 2024-01-30 15:50:10
@article{f3ea9f11-6de7-4972-865c-8f4790bbf537,
abstract = {{<p>Accurate quantitation of activity provides the basis for internal dosimetry of targeted radionuclide therapies. This study investigated quantitative imaging capabilities at sites with a variety of experience and equipment and assessed levels of errors in activity quantitation in Single-Photon Emission Computed Tomography (SPECT) and planar imaging. Participants from 9 countries took part in a comparison in which planar, SPECT and SPECT with X ray computed tomography (SPECT-CT) imaging were used to quantify activities of four epoxy-filled cylinders containing 133Ba, which was chosen as a surrogate for 131I. The sources, with nominal volumes of 2, 4, 6 and 23mL, were calibrated for 133Ba activity by the National Institute of Standards and Technology, but the activity was initially unknown to the participants. Imaging was performed in a cylindrical phantom filled with water. Two trials were carried out in which the participants first estimated the activities using their local standard protocols, and then repeated the measurements using a standardized acquisition and analysis protocol. Finally, processing of the imaging data from the second trial was repeated by a single centre using a fixed protocol. In the first trial, the activities were underestimated by about 15% with planar imaging. SPECT with Chang's first order attenuation correction (Chang-AC) and SPECT-CT overestimated the activity by about 10%. The second trial showed moderate improvements in accuracy and variability. Planar imaging was subject to methodological errors, e.g., in the use of a transmission scan for attenuation correction. The use of Chang-AC was subject to variability from the definition of phantom contours. The project demonstrated the need for training and standardized protocols to achieve good levels of quantitative accuracy and precision in a multicentre setting. Absolute quantification of simple objects with no background was possible with the strictest protocol to about 6% with planar imaging and SPECT (with Chang-AC) and within 2% for SPECT-CT.</p>}},
author = {{Zimmerman, Brian E and Grošev, Darko and Buvat, Irène and Coca Pérez, Marco A and Frey, Eric C and Green, Alan and Krisanachinda, Anchali and Lassmann, Michael and Ljungberg, Michael and Pozzo, Lorena and Quadir, Kamila Afroj and Terán Gretter, Mariella A and Van Staden, Johann and Poli, Gian Luca}},
issn = {{1876-4436}},
keywords = {{Humans; Image Processing, Computer-Assisted; Phantoms, Imaging/standards; Radiometry; Reproducibility of Results; Tomography, Emission-Computed, Single-Photon/methods}},
language = {{eng}},
number = {{2}},
pages = {{98--112}},
publisher = {{Elsevier}},
series = {{Zeitschrift für Medizinische Physik}},
title = {{Multi-centre evaluation of accuracy and reproducibility of planar and SPECT image quantification : An IAEA phantom study}},
url = {{http://dx.doi.org/10.1016/j.zemedi.2016.03.008}},
doi = {{10.1016/j.zemedi.2016.03.008}},
volume = {{27}},
year = {{2017}},
}