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Controversial role of toll-like receptors in acute pancreatitis.

Vaz, Juan LU ; Akbarshahi, Hamid LU and Andersson, Roland LU (2013) In World Journal of Gastroenterology 19(5). p.616-630
Abstract
Acute pancreatitis (AP) is a common clinical condition with an incidence of about 300 or more patients per million annually. About 10%-15% of patients will develop severe acute pancreatitis (SAP) and of those, 10%-30% may die due to SAP-associated complications. Despite the improvements done in the diagnosis and management of AP, the mortality rate has not significantly declined during the last decades. Toll-like receptors (TLRs) are pattern-recognition receptors that seem to play a major role in the development of numerous diseases, which make these molecules attractive as potential therapeutic targets. TLRs are involved in the development of the systemic inflammatory response syndrome, a potentially lethal complication in SAP. In the... (More)
Acute pancreatitis (AP) is a common clinical condition with an incidence of about 300 or more patients per million annually. About 10%-15% of patients will develop severe acute pancreatitis (SAP) and of those, 10%-30% may die due to SAP-associated complications. Despite the improvements done in the diagnosis and management of AP, the mortality rate has not significantly declined during the last decades. Toll-like receptors (TLRs) are pattern-recognition receptors that seem to play a major role in the development of numerous diseases, which make these molecules attractive as potential therapeutic targets. TLRs are involved in the development of the systemic inflammatory response syndrome, a potentially lethal complication in SAP. In the present review, we explore the current knowledge about the role of different TLRs that have been described associated with AP. The main candidate for targeting seems to be TLR4, which recognizes numerous damage-associated molecular patterns related to AP. TLR2 has also been linked with AP, but there are only limited studies that exclusively studied its role in AP. There is also data suggesting that TLR9 may play a role in AP. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Acute pancreatitis, Intervention, Pathophysiological mechanism, Severe acute pancreatitis, Toll-like receptors
in
World Journal of Gastroenterology
volume
19
issue
5
pages
616 - 630
publisher
WJG Press
external identifiers
  • wos:000314468100002
  • pmid:23431068
  • scopus:84873684086
ISSN
1007-9327
DOI
10.3748/wjg.v19.i5.616
language
English
LU publication?
yes
id
f403d18a-a2b3-436a-9791-411d3dbab2ac (old id 3559531)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23431068?dopt=Abstract
date added to LUP
2013-03-04 11:11:49
date last changed
2019-02-20 02:03:06
@article{f403d18a-a2b3-436a-9791-411d3dbab2ac,
  abstract     = {Acute pancreatitis (AP) is a common clinical condition with an incidence of about 300 or more patients per million annually. About 10%-15% of patients will develop severe acute pancreatitis (SAP) and of those, 10%-30% may die due to SAP-associated complications. Despite the improvements done in the diagnosis and management of AP, the mortality rate has not significantly declined during the last decades. Toll-like receptors (TLRs) are pattern-recognition receptors that seem to play a major role in the development of numerous diseases, which make these molecules attractive as potential therapeutic targets. TLRs are involved in the development of the systemic inflammatory response syndrome, a potentially lethal complication in SAP. In the present review, we explore the current knowledge about the role of different TLRs that have been described associated with AP. The main candidate for targeting seems to be TLR4, which recognizes numerous damage-associated molecular patterns related to AP. TLR2 has also been linked with AP, but there are only limited studies that exclusively studied its role in AP. There is also data suggesting that TLR9 may play a role in AP.},
  author       = {Vaz, Juan and Akbarshahi, Hamid and Andersson, Roland},
  issn         = {1007-9327},
  keyword      = {Acute pancreatitis,Intervention,Pathophysiological mechanism,Severe acute pancreatitis,Toll-like receptors},
  language     = {eng},
  number       = {5},
  pages        = {616--630},
  publisher    = {WJG Press},
  series       = {World Journal of Gastroenterology},
  title        = {Controversial role of toll-like receptors in acute pancreatitis.},
  url          = {http://dx.doi.org/10.3748/wjg.v19.i5.616},
  volume       = {19},
  year         = {2013},
}