Complement evasion by the human respiratory tract pathogens Haemophilus influenzae and Moraxella catarrhalis
Riesbeck, Kristian LU
(2020)
In FEBS Letters
594(16).
p.2586-2597
- Abstract
All infective bacterial species need to conquer the innate immune system in order to colonize and survive in their hosts. The human respiratory pathogens Haemophilus influenzae and Moraxella catarrhalis are no exceptions and have developed sophisticated mechanisms to evade complement-mediated killing. Both bacterial species carry lipooligosaccharides preventing complement attacks and attract and utilize host complement regulators C4b binding protein and factor H to inhibit the classical and alternative pathways of complement activation, respectively. In addition, the regulator of the terminal pathway of complement activation, vitronectin, is hijacked by both bacteria. An array of different outer membrane proteins (OMP) in H. influenzae... (More)
All infective bacterial species need to conquer the innate immune system in order to colonize and survive in their hosts. The human respiratory pathogens Haemophilus influenzae and Moraxella catarrhalis are no exceptions and have developed sophisticated mechanisms to evade complement-mediated killing. Both bacterial species carry lipooligosaccharides preventing complement attacks and attract and utilize host complement regulators C4b binding protein and factor H to inhibit the classical and alternative pathways of complement activation, respectively. In addition, the regulator of the terminal pathway of complement activation, vitronectin, is hijacked by both bacteria. An array of different outer membrane proteins (OMP) in H. influenzae and M. catarrhalis simultaneously binds complement regulators, but also plasminogen. Several of the bacterial complement-binding proteins are important adhesins and contain highly conserved regions for interactions with the host. Thus, some of the OMP are viable targets for new therapeutics, including vaccines aimed at preventing respiratory tract diseases such as otitis media in children and exacerbations in patients suffering from chronic obstructive pulmonary disease.
(Less)
- author
- Riesbeck, Kristian
LU
- organization
- publishing date
- 2020-08
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- complement, evasion, Haemophilus influenzae, Moraxella catarrhalis, serum resistance
- in
- FEBS Letters
- volume
- 594
- issue
- 16
- pages
- 12 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85081267211
- pmid:32053211
- ISSN
- 0014-5793
- DOI
- 10.1002/1873-3468.13758
- language
- English
- LU publication?
- yes
- id
- f4429d9c-8faf-4777-b88e-54c8d7bd6073
- date added to LUP
- 2020-04-07 16:08:08
- date last changed
- 2024-06-12 11:57:01
@article{f4429d9c-8faf-4777-b88e-54c8d7bd6073,
abstract = {{<p>All infective bacterial species need to conquer the innate immune system in order to colonize and survive in their hosts. The human respiratory pathogens Haemophilus influenzae and Moraxella catarrhalis are no exceptions and have developed sophisticated mechanisms to evade complement-mediated killing. Both bacterial species carry lipooligosaccharides preventing complement attacks and attract and utilize host complement regulators C4b binding protein and factor H to inhibit the classical and alternative pathways of complement activation, respectively. In addition, the regulator of the terminal pathway of complement activation, vitronectin, is hijacked by both bacteria. An array of different outer membrane proteins (OMP) in H. influenzae and M. catarrhalis simultaneously binds complement regulators, but also plasminogen. Several of the bacterial complement-binding proteins are important adhesins and contain highly conserved regions for interactions with the host. Thus, some of the OMP are viable targets for new therapeutics, including vaccines aimed at preventing respiratory tract diseases such as otitis media in children and exacerbations in patients suffering from chronic obstructive pulmonary disease.</p>}},
author = {{Riesbeck, Kristian}},
issn = {{0014-5793}},
keywords = {{complement; evasion; Haemophilus influenzae; Moraxella catarrhalis; serum resistance}},
language = {{eng}},
number = {{16}},
pages = {{2586--2597}},
publisher = {{Wiley-Blackwell}},
series = {{FEBS Letters}},
title = {{Complement evasion by the human respiratory tract pathogens Haemophilus influenzae and Moraxella catarrhalis}},
url = {{http://dx.doi.org/10.1002/1873-3468.13758}},
doi = {{10.1002/1873-3468.13758}},
volume = {{594}},
year = {{2020}},
}