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Effects of pancreozymin and secretin on insulin release and the role of the exocrine pancreas

Danielsson, Å and Lernmark, Å LU orcid (1974) In Diabetologia 10(5). p.407-409
Abstract

Mouse pancreatic islets microdissected free from, or surrounded by, exocrine cells were used to study the effects of secretin and choleeystokinm-pancreozymin on insulin release. Both secretin and cholecystokinin-pancreozymin potentiated glucose-stimulated insulin release regardless of whether exocrine cells were present. The results fail to support the idea that the presence of the exocrine parenchyma is essential for elicitation of insulin release by these gastrointestinal hormones.

Please use this url to cite or link to this publication:
author
and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
exocrine cells, Insulin release, mouse islets, pancreozymin, secretin
in
Diabetologia
volume
10
issue
5
pages
3 pages
publisher
Springer
external identifiers
  • scopus:0016210330
  • pmid:4615962
ISSN
0012-186X
DOI
10.1007/BF01221629
language
English
LU publication?
no
id
f4577e7f-c8cf-4c15-8cde-8bdf3b442f11
date added to LUP
2019-09-18 12:16:47
date last changed
2024-03-13 08:00:39
@article{f4577e7f-c8cf-4c15-8cde-8bdf3b442f11,
  abstract     = {{<p>Mouse pancreatic islets microdissected free from, or surrounded by, exocrine cells were used to study the effects of secretin and choleeystokinm-pancreozymin on insulin release. Both secretin and cholecystokinin-pancreozymin potentiated glucose-stimulated insulin release regardless of whether exocrine cells were present. The results fail to support the idea that the presence of the exocrine parenchyma is essential for elicitation of insulin release by these gastrointestinal hormones.</p>}},
  author       = {{Danielsson, Å and Lernmark, Å}},
  issn         = {{0012-186X}},
  keywords     = {{exocrine cells; Insulin release; mouse islets; pancreozymin; secretin}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{5}},
  pages        = {{407--409}},
  publisher    = {{Springer}},
  series       = {{Diabetologia}},
  title        = {{Effects of pancreozymin and secretin on insulin release and the role of the exocrine pancreas}},
  url          = {{http://dx.doi.org/10.1007/BF01221629}},
  doi          = {{10.1007/BF01221629}},
  volume       = {{10}},
  year         = {{1974}},
}