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Co-localization of CD169+ macrophages and cancer cells in lymph node metastases of breast cancer patients is linked to improved prognosis and PDL1 expression

Björk Gunnarsdottir, Frida LU ; Auoja, Nathalie LU ; Bendahl, Pär Ola LU ; Rydén, Lisa LU orcid ; Fernö, Mårten LU and Leandersson, Karin LU orcid (2020) In OncoImmunology 9(1).
Abstract

Breast cancer is the most common form of cancer in women worldwide. Although the survival among breast cancer patients has improved, there is still a large group of patients with dismal prognosis. One of the most important prognostic factors for poor prognosis is lymph node metastasis. Increasing knowledge concerning the lymph nodes of breast cancer patients indicates that they are affected by the primary tumor. In this study we show that presence of CD169+ subcapsular sinus macrophages in contact with lymph node metastases in breast cancer patients, is related to better prognosis after adjuvant tamoxifen treatment, but only in patients with PDL1+ primary tumors. This is in contrast to the prognostic effect of... (More)

Breast cancer is the most common form of cancer in women worldwide. Although the survival among breast cancer patients has improved, there is still a large group of patients with dismal prognosis. One of the most important prognostic factors for poor prognosis is lymph node metastasis. Increasing knowledge concerning the lymph nodes of breast cancer patients indicates that they are affected by the primary tumor. In this study we show that presence of CD169+ subcapsular sinus macrophages in contact with lymph node metastases in breast cancer patients, is related to better prognosis after adjuvant tamoxifen treatment, but only in patients with PDL1+ primary tumors. This is in contrast to the prognostic effect of CD169+ primary tumor-associated macrophages (TAMs). We further show that CD169+ macrophages were spatially associated with expression of PDL1 on nearby cells, both in primary tumors and metastatic lymph node, although PDL1 expression in metastatic lymph node as such did not have further prognostic impact. Our data suggest that CD169+ resident lymph node macrophages have a unique function in targeting immune responses against breast cancer and should be further investigated in detail.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Breast cancer, CD169, lymph node, macrophage, PDL1
in
OncoImmunology
volume
9
issue
1
article number
1848067
publisher
Landes Bioscience
external identifiers
  • pmid:33299660
  • scopus:85096400844
ISSN
2162-4011
DOI
10.1080/2162402X.2020.1848067
language
English
LU publication?
yes
id
f4605cb6-e3f4-46a1-8c36-4dc9c43fb7c3
date added to LUP
2020-12-02 07:36:34
date last changed
2024-04-03 18:52:51
@article{f4605cb6-e3f4-46a1-8c36-4dc9c43fb7c3,
  abstract     = {{<p>Breast cancer is the most common form of cancer in women worldwide. Although the survival among breast cancer patients has improved, there is still a large group of patients with dismal prognosis. One of the most important prognostic factors for poor prognosis is lymph node metastasis. Increasing knowledge concerning the lymph nodes of breast cancer patients indicates that they are affected by the primary tumor. In this study we show that presence of CD169<sup>+</sup> subcapsular sinus macrophages in contact with lymph node metastases in breast cancer patients, is related to better prognosis after adjuvant tamoxifen treatment, but only in patients with PDL1<sup>+</sup> primary tumors. This is in contrast to the prognostic effect of CD169<sup>+</sup> primary tumor-associated macrophages (TAMs). We further show that CD169<sup>+</sup> macrophages were spatially associated with expression of PDL1 on nearby cells, both in primary tumors and metastatic lymph node, although PDL1 expression in metastatic lymph node as such did not have further prognostic impact. Our data suggest that CD169<sup>+</sup> resident lymph node macrophages have a unique function in targeting immune responses against breast cancer and should be further investigated in detail.</p>}},
  author       = {{Björk Gunnarsdottir, Frida and Auoja, Nathalie and Bendahl, Pär Ola and Rydén, Lisa and Fernö, Mårten and Leandersson, Karin}},
  issn         = {{2162-4011}},
  keywords     = {{Breast cancer; CD169; lymph node; macrophage; PDL1}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Landes Bioscience}},
  series       = {{OncoImmunology}},
  title        = {{Co-localization of CD169<sup>+</sup> macrophages and cancer cells in lymph node metastases of breast cancer patients is linked to improved prognosis and PDL1 expression}},
  url          = {{http://dx.doi.org/10.1080/2162402X.2020.1848067}},
  doi          = {{10.1080/2162402X.2020.1848067}},
  volume       = {{9}},
  year         = {{2020}},
}