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Familial risk of lymphoproliferative tumors in families of patients with chronic lymphocytic leukemia : results from the Swedish Family-Cancer Database

Goldin, Lynn R; Pfeiffer, Ruth M; Li, Xinjun LU and Hemminki, Kari LU (2004) In Blood 104(6). p.4-1850
Abstract

The importance of genetic factors in etiology of chronic lymphocytic leukemia (CLL) is suggested by family and population studies. However, the spectrum of malignancies sharing common genetic factors with CLL and the effects of sex and age on familial risk are unknown. We used the Swedish Family-Cancer Database to test for increased familial risks of CLL and other lymphoproliferative tumors. Cancer diagnoses from 1958 to 1998 were assessed in 14 336 first-degree relatives of 5918 CLL cases and in 28 876 first-degree relatives of 11 778 controls. Cancer risks in relatives of cases were compared with those in relatives of controls using marginal survival models. Relatives of cases were at significantly increased risk for CLL (relative... (More)

The importance of genetic factors in etiology of chronic lymphocytic leukemia (CLL) is suggested by family and population studies. However, the spectrum of malignancies sharing common genetic factors with CLL and the effects of sex and age on familial risk are unknown. We used the Swedish Family-Cancer Database to test for increased familial risks of CLL and other lymphoproliferative tumors. Cancer diagnoses from 1958 to 1998 were assessed in 14 336 first-degree relatives of 5918 CLL cases and in 28 876 first-degree relatives of 11 778 controls. Cancer risks in relatives of cases were compared with those in relatives of controls using marginal survival models. Relatives of cases were at significantly increased risk for CLL (relative risk [RR] = 7.52; 95% confidence interval [CI], 3.63-15.56), for non-Hodgkin lymphoma (RR = 1.45; 95% CI, 0.98-2.16), and for Hodgkin lymphoma (RR = 2.35; 95% CI, 1.08-5.08). CLL risks were similar in parents, siblings, and offspring of cases, in male and female relatives, and were not affected by the case's age at diagnosis. Anticipation was not significant when analyzed using life table methods. We conclude that the familial component of CLL is shared with other lymphoproliferative malignances, suggesting common genetic pathways. However, because clinically diagnosed CLL is uncommon, absolute excess risk to relatives is small.

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Contribution to journal
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published
subject
keywords
Age of Onset, Aged, Anticipation, Genetic, Case-Control Studies, Databases, Factual, Family Health, Female, Genetic Predisposition to Disease/genetics, Humans, Leukemia, Lymphocytic, Chronic, B-Cell/epidemiology, Male, Middle Aged, Organ Specificity, Risk Factors, Sweden/epidemiology
in
Blood
volume
104
issue
6
pages
5 pages
publisher
American Society of Hematology
external identifiers
  • scopus:3242736321
ISSN
0006-4971
DOI
10.1182/blood-2004-01-0341
language
English
LU publication?
no
id
f47915c2-c03b-4af7-95de-cadda105e9ae
date added to LUP
2019-01-30 11:43:36
date last changed
2019-04-02 04:13:26
@article{f47915c2-c03b-4af7-95de-cadda105e9ae,
  abstract     = {<p>The importance of genetic factors in etiology of chronic lymphocytic leukemia (CLL) is suggested by family and population studies. However, the spectrum of malignancies sharing common genetic factors with CLL and the effects of sex and age on familial risk are unknown. We used the Swedish Family-Cancer Database to test for increased familial risks of CLL and other lymphoproliferative tumors. Cancer diagnoses from 1958 to 1998 were assessed in 14 336 first-degree relatives of 5918 CLL cases and in 28 876 first-degree relatives of 11 778 controls. Cancer risks in relatives of cases were compared with those in relatives of controls using marginal survival models. Relatives of cases were at significantly increased risk for CLL (relative risk [RR] = 7.52; 95% confidence interval [CI], 3.63-15.56), for non-Hodgkin lymphoma (RR = 1.45; 95% CI, 0.98-2.16), and for Hodgkin lymphoma (RR = 2.35; 95% CI, 1.08-5.08). CLL risks were similar in parents, siblings, and offspring of cases, in male and female relatives, and were not affected by the case's age at diagnosis. Anticipation was not significant when analyzed using life table methods. We conclude that the familial component of CLL is shared with other lymphoproliferative malignances, suggesting common genetic pathways. However, because clinically diagnosed CLL is uncommon, absolute excess risk to relatives is small.</p>},
  author       = {Goldin, Lynn R and Pfeiffer, Ruth M and Li, Xinjun and Hemminki, Kari},
  issn         = {0006-4971},
  keyword      = {Age of Onset,Aged,Anticipation, Genetic,Case-Control Studies,Databases, Factual,Family Health,Female,Genetic Predisposition to Disease/genetics,Humans,Leukemia, Lymphocytic, Chronic, B-Cell/epidemiology,Male,Middle Aged,Organ Specificity,Risk Factors,Sweden/epidemiology},
  language     = {eng},
  month        = {09},
  number       = {6},
  pages        = {4--1850},
  publisher    = {American Society of Hematology},
  series       = {Blood},
  title        = {Familial risk of lymphoproliferative tumors in families of patients with chronic lymphocytic leukemia : results from the Swedish Family-Cancer Database},
  url          = {http://dx.doi.org/10.1182/blood-2004-01-0341},
  volume       = {104},
  year         = {2004},
}