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Frequent development of chronic obstructive pulmonary disease in primary SS--results of a longitudinal follow-up.

Mandl, Thomas LU orcid ; Diaz, Sandra LU ; Ekberg, Olle LU ; Hesselstrand, Roger LU ; Piitulainen, Eeva LU ; Wollmer, Per LU and Theander, Elke LU (2012) In Rheumatology 51(5). p.941-946
Abstract
Objectives. To study the longitudinal development of pulmonary function in patients with primary SS (pSS) and its association with respiratory symptoms, pulmonary radiographic findings and clinical features of pSS.Methods. Forty-one pSS patients, previously evaluated by pulmonary function tests (PFTs), were included in the study. The patients were studied at baseline and follow-up by PFT and at follow-up also by high-resolution CT scan of the lungs, the St George's Respiratory Questionnaire and by inflammatory and serological tests. The PFT results were compared with previously studied population-based controls, standardizing results with regard to gender, age, height, weight and tobacco consumption.Results. The mean follow-up time was 11... (More)
Objectives. To study the longitudinal development of pulmonary function in patients with primary SS (pSS) and its association with respiratory symptoms, pulmonary radiographic findings and clinical features of pSS.Methods. Forty-one pSS patients, previously evaluated by pulmonary function tests (PFTs), were included in the study. The patients were studied at baseline and follow-up by PFT and at follow-up also by high-resolution CT scan of the lungs, the St George's Respiratory Questionnaire and by inflammatory and serological tests. The PFT results were compared with previously studied population-based controls, standardizing results with regard to gender, age, height, weight and tobacco consumption.Results. The mean follow-up time was 11 years. The pSS patients displayed signs of both obstructive and restrictive lung disease at baseline and at follow-up, and deteriorated in forced expiratory volume in 1 s (FEV(1)), ratio of FEV(1) to vital capacity and in diffusing capacity for carbon monoxide during follow-up. Chronic obstructive pulmonary disease (COPD) was diagnosed in 37% of the pSS patients at follow-up. In pSS patients, respiratory symptoms and radiographic abnormalities were common, although with a poor association with PFT variables.Conclusion. The pSS patients showed signs of both obstructive and restrictive pulmonary disease and COPD commonly developed during follow-up. Respiratory symptoms and radiographic abnormalities were common but poorly associated with PFT in pSS patients. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
primary Sjogren's syndrome, pulmonary function, follow-up study
in
Rheumatology
volume
51
issue
5
pages
941 - 946
publisher
Oxford University Press
external identifiers
  • wos:000303159800027
  • pmid:22258389
  • scopus:84860232917
  • pmid:22258389
ISSN
1462-0332
DOI
10.1093/rheumatology/ker409
language
English
LU publication?
yes
id
f49988e5-4a23-49b0-aced-ba43f8c8d211 (old id 2336185)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22258389?dopt=Abstract
date added to LUP
2016-04-01 12:59:29
date last changed
2025-10-14 13:19:16
@article{f49988e5-4a23-49b0-aced-ba43f8c8d211,
  abstract     = {{Objectives. To study the longitudinal development of pulmonary function in patients with primary SS (pSS) and its association with respiratory symptoms, pulmonary radiographic findings and clinical features of pSS.Methods. Forty-one pSS patients, previously evaluated by pulmonary function tests (PFTs), were included in the study. The patients were studied at baseline and follow-up by PFT and at follow-up also by high-resolution CT scan of the lungs, the St George's Respiratory Questionnaire and by inflammatory and serological tests. The PFT results were compared with previously studied population-based controls, standardizing results with regard to gender, age, height, weight and tobacco consumption.Results. The mean follow-up time was 11 years. The pSS patients displayed signs of both obstructive and restrictive lung disease at baseline and at follow-up, and deteriorated in forced expiratory volume in 1 s (FEV(1)), ratio of FEV(1) to vital capacity and in diffusing capacity for carbon monoxide during follow-up. Chronic obstructive pulmonary disease (COPD) was diagnosed in 37% of the pSS patients at follow-up. In pSS patients, respiratory symptoms and radiographic abnormalities were common, although with a poor association with PFT variables.Conclusion. The pSS patients showed signs of both obstructive and restrictive pulmonary disease and COPD commonly developed during follow-up. Respiratory symptoms and radiographic abnormalities were common but poorly associated with PFT in pSS patients.}},
  author       = {{Mandl, Thomas and Diaz, Sandra and Ekberg, Olle and Hesselstrand, Roger and Piitulainen, Eeva and Wollmer, Per and Theander, Elke}},
  issn         = {{1462-0332}},
  keywords     = {{primary Sjogren's syndrome; pulmonary function; follow-up study}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{941--946}},
  publisher    = {{Oxford University Press}},
  series       = {{Rheumatology}},
  title        = {{Frequent development of chronic obstructive pulmonary disease in primary SS--results of a longitudinal follow-up.}},
  url          = {{http://dx.doi.org/10.1093/rheumatology/ker409}},
  doi          = {{10.1093/rheumatology/ker409}},
  volume       = {{51}},
  year         = {{2012}},
}