Frequent development of chronic obstructive pulmonary disease in primary SS--results of a longitudinal follow-up.
(2012) In Rheumatology 51(5). p.941-946- Abstract
- Objectives. To study the longitudinal development of pulmonary function in patients with primary SS (pSS) and its association with respiratory symptoms, pulmonary radiographic findings and clinical features of pSS.Methods. Forty-one pSS patients, previously evaluated by pulmonary function tests (PFTs), were included in the study. The patients were studied at baseline and follow-up by PFT and at follow-up also by high-resolution CT scan of the lungs, the St George's Respiratory Questionnaire and by inflammatory and serological tests. The PFT results were compared with previously studied population-based controls, standardizing results with regard to gender, age, height, weight and tobacco consumption.Results. The mean follow-up time was 11... (More)
- Objectives. To study the longitudinal development of pulmonary function in patients with primary SS (pSS) and its association with respiratory symptoms, pulmonary radiographic findings and clinical features of pSS.Methods. Forty-one pSS patients, previously evaluated by pulmonary function tests (PFTs), were included in the study. The patients were studied at baseline and follow-up by PFT and at follow-up also by high-resolution CT scan of the lungs, the St George's Respiratory Questionnaire and by inflammatory and serological tests. The PFT results were compared with previously studied population-based controls, standardizing results with regard to gender, age, height, weight and tobacco consumption.Results. The mean follow-up time was 11 years. The pSS patients displayed signs of both obstructive and restrictive lung disease at baseline and at follow-up, and deteriorated in forced expiratory volume in 1 s (FEV(1)), ratio of FEV(1) to vital capacity and in diffusing capacity for carbon monoxide during follow-up. Chronic obstructive pulmonary disease (COPD) was diagnosed in 37% of the pSS patients at follow-up. In pSS patients, respiratory symptoms and radiographic abnormalities were common, although with a poor association with PFT variables.Conclusion. The pSS patients showed signs of both obstructive and restrictive pulmonary disease and COPD commonly developed during follow-up. Respiratory symptoms and radiographic abnormalities were common but poorly associated with PFT in pSS patients. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2336185
- author
- Mandl, Thomas LU ; Diaz, Sandra LU ; Ekberg, Olle LU ; Hesselstrand, Roger LU ; Piitulainen, Eeva LU ; Wollmer, Per LU and Theander, Elke LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- primary Sjogren's syndrome, pulmonary function, follow-up study
- in
- Rheumatology
- volume
- 51
- issue
- 5
- pages
- 941 - 946
- publisher
- Oxford University Press
- external identifiers
-
- wos:000303159800027
- pmid:22258389
- scopus:84860232917
- pmid:22258389
- ISSN
- 1462-0332
- DOI
- 10.1093/rheumatology/ker409
- language
- English
- LU publication?
- yes
- id
- f49988e5-4a23-49b0-aced-ba43f8c8d211 (old id 2336185)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22258389?dopt=Abstract
- date added to LUP
- 2016-04-01 12:59:29
- date last changed
- 2023-09-02 17:13:50
@article{f49988e5-4a23-49b0-aced-ba43f8c8d211, abstract = {{Objectives. To study the longitudinal development of pulmonary function in patients with primary SS (pSS) and its association with respiratory symptoms, pulmonary radiographic findings and clinical features of pSS.Methods. Forty-one pSS patients, previously evaluated by pulmonary function tests (PFTs), were included in the study. The patients were studied at baseline and follow-up by PFT and at follow-up also by high-resolution CT scan of the lungs, the St George's Respiratory Questionnaire and by inflammatory and serological tests. The PFT results were compared with previously studied population-based controls, standardizing results with regard to gender, age, height, weight and tobacco consumption.Results. The mean follow-up time was 11 years. The pSS patients displayed signs of both obstructive and restrictive lung disease at baseline and at follow-up, and deteriorated in forced expiratory volume in 1 s (FEV(1)), ratio of FEV(1) to vital capacity and in diffusing capacity for carbon monoxide during follow-up. Chronic obstructive pulmonary disease (COPD) was diagnosed in 37% of the pSS patients at follow-up. In pSS patients, respiratory symptoms and radiographic abnormalities were common, although with a poor association with PFT variables.Conclusion. The pSS patients showed signs of both obstructive and restrictive pulmonary disease and COPD commonly developed during follow-up. Respiratory symptoms and radiographic abnormalities were common but poorly associated with PFT in pSS patients.}}, author = {{Mandl, Thomas and Diaz, Sandra and Ekberg, Olle and Hesselstrand, Roger and Piitulainen, Eeva and Wollmer, Per and Theander, Elke}}, issn = {{1462-0332}}, keywords = {{primary Sjogren's syndrome; pulmonary function; follow-up study}}, language = {{eng}}, number = {{5}}, pages = {{941--946}}, publisher = {{Oxford University Press}}, series = {{Rheumatology}}, title = {{Frequent development of chronic obstructive pulmonary disease in primary SS--results of a longitudinal follow-up.}}, url = {{http://dx.doi.org/10.1093/rheumatology/ker409}}, doi = {{10.1093/rheumatology/ker409}}, volume = {{51}}, year = {{2012}}, }