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Androgens in women after allogeneic hematopoietic cell transplantation : Impact of chronic GvHD and glucocorticoid therapy

Björk, Y.; Smith Knutsson, E.; Ankarberg-Lindgren, Carina; Broman, A. K.; Andersson, I. LU ; Björkman, L. LU ; Magnusson, J. LU ; Bergmark, Karin; Anderson, H. LU and Andersson, Per O., et al. (2017) In Bone Marrow Transplantation 52(3). p.431-437
Abstract

Low androgen levels may contribute to sexual dysfunction in women after allogeneic hematopoietic cell transplantation (alloHCT). However, data on serum androgens in women after alloHCT are limited. The aim of this study was to assess androgen levels and their association with chronic GvHD (cGvHD) and glucocorticoid (GC) therapy. Included were 65 allografted women, 33 with cGvHD, and 23 of these were on GC therapy. Controls were 94 healthy, age-matched women. Supportive study groups were women after autologous HCT (autoHCT; n=20) and non-transplanted women on GC therapy (n=26). Compared with controls, free testosterone (free T) and dehydroepiandrosterone sulfate (DHEAS) levels were lower in both the alloHCT group and GC groups;... (More)

Low androgen levels may contribute to sexual dysfunction in women after allogeneic hematopoietic cell transplantation (alloHCT). However, data on serum androgens in women after alloHCT are limited. The aim of this study was to assess androgen levels and their association with chronic GvHD (cGvHD) and glucocorticoid (GC) therapy. Included were 65 allografted women, 33 with cGvHD, and 23 of these were on GC therapy. Controls were 94 healthy, age-matched women. Supportive study groups were women after autologous HCT (autoHCT; n=20) and non-transplanted women on GC therapy (n=26). Compared with controls, free testosterone (free T) and dehydroepiandrosterone sulfate (DHEAS) levels were lower in both the alloHCT group and GC groups; P<0.0001 and P<0.05, respectively. Androgens in the autoHCT group were similar or higher than controls. In the subgroup of alloHCT patients without cGvHD, free T was similar to controls (7.2 vs 8.6 pmol/L; P=0.42), whereas DHEAS levels was lower than controls (1.7 vs 2.5 μmol/L; P=0.008). Compared with controls, cGvHD without GC (n=10) was associated with lower free T and DHEAS; P=0.004 and P=0.0004, respectively). The lowest androgen levels were seen in women with both cGvHD and GC therapy. In conclusion, low serum androgens were associated with cGvHD and GC therapy, prompting for studies assessing a possible association between low androgens and sexual dysfunction and quality of life in allografted women.

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Contribution to journal
publication status
published
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keywords
androgens, women, allogeneic hematopoietic, glucocorticoid therapy
in
Bone Marrow Transplantation
volume
52
issue
3
pages
7 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:85014558972
  • wos:000395827400014
ISSN
0268-3369
DOI
10.1038/bmt.2016.268
language
English
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yes
id
f4d1ce3b-09cf-47ac-b444-5c9872e64aa3
date added to LUP
2017-03-17 12:36:00
date last changed
2018-01-07 11:56:14
@article{f4d1ce3b-09cf-47ac-b444-5c9872e64aa3,
  abstract     = {<p>Low androgen levels may contribute to sexual dysfunction in women after allogeneic hematopoietic cell transplantation (alloHCT). However, data on serum androgens in women after alloHCT are limited. The aim of this study was to assess androgen levels and their association with chronic GvHD (cGvHD) and glucocorticoid (GC) therapy. Included were 65 allografted women, 33 with cGvHD, and 23 of these were on GC therapy. Controls were 94 healthy, age-matched women. Supportive study groups were women after autologous HCT (autoHCT; n=20) and non-transplanted women on GC therapy (n=26). Compared with controls, free testosterone (free T) and dehydroepiandrosterone sulfate (DHEAS) levels were lower in both the alloHCT group and GC groups; P&lt;0.0001 and P&lt;0.05, respectively. Androgens in the autoHCT group were similar or higher than controls. In the subgroup of alloHCT patients without cGvHD, free T was similar to controls (7.2 vs 8.6 pmol/L; P=0.42), whereas DHEAS levels was lower than controls (1.7 vs 2.5 μmol/L; P=0.008). Compared with controls, cGvHD without GC (n=10) was associated with lower free T and DHEAS; P=0.004 and P=0.0004, respectively). The lowest androgen levels were seen in women with both cGvHD and GC therapy. In conclusion, low serum androgens were associated with cGvHD and GC therapy, prompting for studies assessing a possible association between low androgens and sexual dysfunction and quality of life in allografted women.</p>},
  author       = {Björk, Y. and Smith Knutsson, E. and Ankarberg-Lindgren, Carina and Broman, A. K. and Andersson, I. and Björkman, L. and Magnusson, J. and Bergmark, Karin and Anderson, H. and Andersson, Per O. and Brune, M},
  issn         = {0268-3369},
  keyword      = {androgens,women,allogeneic hematopoietic,glucocorticoid therapy},
  language     = {eng},
  month        = {03},
  number       = {3},
  pages        = {431--437},
  publisher    = {Nature Publishing Group},
  series       = {Bone Marrow Transplantation},
  title        = {Androgens in women after allogeneic hematopoietic cell transplantation : Impact of chronic GvHD and glucocorticoid therapy},
  url          = {http://dx.doi.org/10.1038/bmt.2016.268},
  volume       = {52},
  year         = {2017},
}