Late divergence of survival curves in cancer immunotherapy trials: interpretation and implications
(2013) In Cancer Immunology and Immunotherapy 62(10). p.1547-1551- Abstract
- Late divergence of survival curves of treated patients and controls is commonly seen in successful cancer immunotherapy trials. Although late survival curve divergence may be caused by a delayed action of therapy, it may also be related to early effects of the treatment. We suggest that late survival divergence most often reflects a specific benefit of therapy for patients who suffer from a comparatively slow progression of disease. The occurrence of delayed survival curve divergence has important implications for the statistical analysis of immunotherapy trials. Thus, it leads to non-proportional hazard ratios that make commonly used statistical tests, e.g., the logrank test, suboptimal. It is therefore suggested that the statistical... (More)
- Late divergence of survival curves of treated patients and controls is commonly seen in successful cancer immunotherapy trials. Although late survival curve divergence may be caused by a delayed action of therapy, it may also be related to early effects of the treatment. We suggest that late survival divergence most often reflects a specific benefit of therapy for patients who suffer from a comparatively slow progression of disease. The occurrence of delayed survival curve divergence has important implications for the statistical analysis of immunotherapy trials. Thus, it leads to non-proportional hazard ratios that make commonly used statistical tests, e.g., the logrank test, suboptimal. It is therefore suggested that the statistical analysis of immunotherapy trials primarily should be based on a test that compares the survival curves at or after a prespecified, fixed, late time point. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4172494
- author
- Thoren, Fredrik B. ; Anderson, Harald LU and Strannegard, Orjan
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Immunotherapy, Survival analysis, Kaplan-Meier, Treatment outcome, Late, divergence, Statistical models
- in
- Cancer Immunology and Immunotherapy
- volume
- 62
- issue
- 10
- pages
- 1547 - 1551
- publisher
- Springer
- external identifiers
-
- wos:000325008800001
- scopus:84885836084
- pmid:23979447
- ISSN
- 1432-0851
- DOI
- 10.1007/s00262-013-1458-y
- language
- English
- LU publication?
- yes
- id
- f5467b91-27bf-4cd3-9645-55392a4baace (old id 4172494)
- date added to LUP
- 2016-04-01 13:53:19
- date last changed
- 2022-01-27 21:38:19
@article{f5467b91-27bf-4cd3-9645-55392a4baace,
abstract = {{Late divergence of survival curves of treated patients and controls is commonly seen in successful cancer immunotherapy trials. Although late survival curve divergence may be caused by a delayed action of therapy, it may also be related to early effects of the treatment. We suggest that late survival divergence most often reflects a specific benefit of therapy for patients who suffer from a comparatively slow progression of disease. The occurrence of delayed survival curve divergence has important implications for the statistical analysis of immunotherapy trials. Thus, it leads to non-proportional hazard ratios that make commonly used statistical tests, e.g., the logrank test, suboptimal. It is therefore suggested that the statistical analysis of immunotherapy trials primarily should be based on a test that compares the survival curves at or after a prespecified, fixed, late time point.}},
author = {{Thoren, Fredrik B. and Anderson, Harald and Strannegard, Orjan}},
issn = {{1432-0851}},
keywords = {{Immunotherapy; Survival analysis; Kaplan-Meier; Treatment outcome; Late; divergence; Statistical models}},
language = {{eng}},
number = {{10}},
pages = {{1547--1551}},
publisher = {{Springer}},
series = {{Cancer Immunology and Immunotherapy}},
title = {{Late divergence of survival curves in cancer immunotherapy trials: interpretation and implications}},
url = {{https://lup.lub.lu.se/search/files/3650645/4436550.pdf}},
doi = {{10.1007/s00262-013-1458-y}},
volume = {{62}},
year = {{2013}},
}