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Cylindrocyclin A, a new cytotoxic cyclopeptide from Cylindrocarpon sp.

Weber, Daniela ; Erosa, Gilda LU ; Sterner, Olov LU and Anke, Timm (2006) In Journal of Antibiotics 59(8). p.495-499
Abstract
In the course of a screening of fungal extracts for new metabolites with cytotoxic activities cylindrocyclin A (1) was isolated. The producing strain was identified as Cylindrocarpon sp. by microscopy and ITS rDNA sequence analysis. 1 is a novel compound that exhibits cytotoxic acticity against six different cell lines with IC50 values ranging from 11 to 53 mu M. 1 has no antibacterial or antifungal activity. The compound is a cyclic nonapeptide comprising three alanines, five leucines and one isoleucine. Four amino acids are N-methylated. Its structure was elucidated by spectroscopic methods.
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cylindrocarpon, cytotoxic, new metabolite, cyclopeptide
in
Journal of Antibiotics
volume
59
issue
8
pages
495 - 499
publisher
Japan Antibiotics Research Association
external identifiers
  • wos:000240519800008
  • scopus:33749497718
ISSN
0021-8820
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
id
f56a1635-2b30-4c93-bc18-4caacd14db75 (old id 393071)
alternative location
http://www.jstage.jst.go.jp/article/antibiotics/59/8/59_495/_article
date added to LUP
2016-04-01 15:56:10
date last changed
2022-01-28 08:06:07
@article{f56a1635-2b30-4c93-bc18-4caacd14db75,
  abstract     = {{In the course of a screening of fungal extracts for new metabolites with cytotoxic activities cylindrocyclin A (1) was isolated. The producing strain was identified as Cylindrocarpon sp. by microscopy and ITS rDNA sequence analysis. 1 is a novel compound that exhibits cytotoxic acticity against six different cell lines with IC50 values ranging from 11 to 53 mu M. 1 has no antibacterial or antifungal activity. The compound is a cyclic nonapeptide comprising three alanines, five leucines and one isoleucine. Four amino acids are N-methylated. Its structure was elucidated by spectroscopic methods.}},
  author       = {{Weber, Daniela and Erosa, Gilda and Sterner, Olov and Anke, Timm}},
  issn         = {{0021-8820}},
  keywords     = {{cylindrocarpon; cytotoxic; new metabolite; cyclopeptide}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{495--499}},
  publisher    = {{Japan Antibiotics Research Association}},
  series       = {{Journal of Antibiotics}},
  title        = {{Cylindrocyclin A, a new cytotoxic cyclopeptide from Cylindrocarpon sp.}},
  url          = {{http://www.jstage.jst.go.jp/article/antibiotics/59/8/59_495/_article}},
  volume       = {{59}},
  year         = {{2006}},
}