How do non-differentiating bacteria adapt to starvation?
(1993) In Antonie van Leeuwenhoek 63(3-4). p.333-341- Abstract
Non-differentiating bacteria adapt to starvation induced growth arrest by a complex turn-on/turn-off pattern of protein synthesis. This response shows distinct similarities with those of spore formation in differentiating organisms. A substantial amount of information on the non-growth biology of non-differentiating bacteria can be derived from studies on Vibrio strains. One important result is that carbon rather than nitrogen or phosphorus starvation leads to the development of a starvation and stress resistant cell in these organisms. Hence, we have attempted to characterize the carbon starvation stimulon. By the use of two-dimensional gel electrophoresis of pulse-labelled cells and transposon mutagenesis, using reporter gene... (More)
Non-differentiating bacteria adapt to starvation induced growth arrest by a complex turn-on/turn-off pattern of protein synthesis. This response shows distinct similarities with those of spore formation in differentiating organisms. A substantial amount of information on the non-growth biology of non-differentiating bacteria can be derived from studies on Vibrio strains. One important result is that carbon rather than nitrogen or phosphorus starvation leads to the development of a starvation and stress resistant cell in these organisms. Hence, we have attempted to characterize the carbon starvation stimulon. By the use of two-dimensional gel electrophoresis of pulse-labelled cells and transposon mutagenesis, using reporter gene constructs, the identity and function of some members of the carbon starvation stimulon have been elucidated. Moreover, regulatory genes of the starvation response have been identified with these techniques. Current studies primarily address the identity and function of these genes. The role of transcript modification and stability for both long term persistence during starvation as well as the efficient recovery of cells which occurs upon nutrient addition is also addressed. It is suggested that an understanding of the functionality of the translational machinery is essential for the understanding of these adaptive pathways. This contribution also discusses the diversity of the differentiation-like response to starvation in different bacteria and whether a general starvation induced programme exists.
(Less)
- author
- Kjelleberg, Staffan ; Albertson, Nan ; Flärdh, Klas LU ; Holmquist, Louise ; Jouper-Jaan, Åsa ; Marouga, Rita ; Östling, Jörgen ; Svenblad, Björn and Weichart, Dieter
- publishing date
- 1993-09
- type
- Contribution to journal
- publication status
- published
- keywords
- carbon, carbon starvation stimulon, nitrogen, phosphorus, protein synthesis, starvation, stress, survival, Vibrio
- in
- Antonie van Leeuwenhoek
- volume
- 63
- issue
- 3-4
- pages
- 9 pages
- publisher
- Springer
- external identifiers
-
- pmid:8279828
- scopus:0027489706
- ISSN
- 0003-6072
- DOI
- 10.1007/BF00871228
- language
- English
- LU publication?
- no
- id
- f58608ab-7e2f-4870-b450-e67b54eab121
- date added to LUP
- 2025-12-14 21:21:55
- date last changed
- 2025-12-17 17:28:39
@article{f58608ab-7e2f-4870-b450-e67b54eab121,
abstract = {{<p>Non-differentiating bacteria adapt to starvation induced growth arrest by a complex turn-on/turn-off pattern of protein synthesis. This response shows distinct similarities with those of spore formation in differentiating organisms. A substantial amount of information on the non-growth biology of non-differentiating bacteria can be derived from studies on Vibrio strains. One important result is that carbon rather than nitrogen or phosphorus starvation leads to the development of a starvation and stress resistant cell in these organisms. Hence, we have attempted to characterize the carbon starvation stimulon. By the use of two-dimensional gel electrophoresis of pulse-labelled cells and transposon mutagenesis, using reporter gene constructs, the identity and function of some members of the carbon starvation stimulon have been elucidated. Moreover, regulatory genes of the starvation response have been identified with these techniques. Current studies primarily address the identity and function of these genes. The role of transcript modification and stability for both long term persistence during starvation as well as the efficient recovery of cells which occurs upon nutrient addition is also addressed. It is suggested that an understanding of the functionality of the translational machinery is essential for the understanding of these adaptive pathways. This contribution also discusses the diversity of the differentiation-like response to starvation in different bacteria and whether a general starvation induced programme exists.</p>}},
author = {{Kjelleberg, Staffan and Albertson, Nan and Flärdh, Klas and Holmquist, Louise and Jouper-Jaan, Åsa and Marouga, Rita and Östling, Jörgen and Svenblad, Björn and Weichart, Dieter}},
issn = {{0003-6072}},
keywords = {{carbon; carbon starvation stimulon; nitrogen; phosphorus; protein synthesis; starvation; stress; survival; Vibrio}},
language = {{eng}},
number = {{3-4}},
pages = {{333--341}},
publisher = {{Springer}},
series = {{Antonie van Leeuwenhoek}},
title = {{How do non-differentiating bacteria adapt to starvation?}},
url = {{http://dx.doi.org/10.1007/BF00871228}},
doi = {{10.1007/BF00871228}},
volume = {{63}},
year = {{1993}},
}